Organic Electronics for Point-of-Care Metabolite Monitoring

Pappa, Anna‐Maria; Parlak, Onur; Scheiblin, Gaëtan; Mailley, Pascal; Salleo, Alberto; Owens, Róisı́n M.

doi:10.1016/j.tibtech.2017.10.022

Cited by 113 publications

(115 citation statements)

References 96 publications

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“…Strategies to transduce chemical signals include transistors, amperometric and voltammetric sensors . Among these transducing elements, organic electrochemical transistors (OECTs) have emerged as a promising transducer for bioelectronics due to their high transconductance (≈2 mS) at low voltages (<0.5 V) . OECTs work by converting ionic currents between two electrodes to a modulation in conductance of a conductive polymer film, making them well‐suited for detection of charged species in an electrolyte solution such as many bodily fluids including sweat.…”

Section: Introductionmentioning

confidence: 99%

Wearable Organic Electrochemical Transistor Patch for Multiplexed Sensing of Calcium and Ammonium Ions from Human Perspiration

Keene

Fogarty

Cooke

et al. 2019

Adv Healthcare Materials

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146

115

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Wearable health monitoring has garnered considerable interest from the healthcare industry as an evolutionary alternative to standard practices with the ability to provide rapid, off‐site diagnosis and patient‐monitoring. In particular, sweat‐based wearable biosensors offer a noninvasive route to continuously monitor a variety of biomarkers for a range of physiological conditions. Both the accessibility and wealth of information of sweat make it an ideal target for noninvasive devices that can aid in early diagnosis of disease or to monitor athletic performance. Here, the integration of ammonium (NH4+) and calcium (Ca2+) ion‐selective membranes with a poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)‐based (PEDOT:PSS) organic electrochemical transistor (OECT) for multiplexed sensing of NH4+ and Ca2+ in sweat with high sensitivity and selectivity is reported for the first time. The presented wearable sweat sensor is designed by combining a flexible and stretchable styrene‐ethylene‐butene‐styrene substrate with a laser‐patterned microcapillary channel array for direct sweat acquisition and delivery to the ion‐selective OECT. The resulting dermal sensor exhibits a wide working range between 0.01 × 10−3 and 100 × 10−3 m, well within the physiological levels of NH4+ and Ca2+ in sweat. The integrated devices are successfully implemented with both ex situ measurements and on human subjects with real‐time analysis using a wearable sensor assembly.

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Section: Introductionmentioning

confidence: 99%

Wearable Organic Electrochemical Transistor Patch for Multiplexed Sensing of Calcium and Ammonium Ions from Human Perspiration

Keene

Fogarty

Cooke

et al. 2019

Adv Healthcare Materials

Self Cite

146

115

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“…The majority of OECT-based metabolite sensing relies on the amperometric detection of the bioanalyte upon its interaction with a biorecognition element present in the device (A.-M. Pappa et al, 2018). This technique relies on the drain current output of the device and the sensitivity ranges between nA and µA (Tang, Yan, Lin, Xu, & Chan, 2011;Zhang et al, 2015).…”

mentioning

confidence: 99%

“…One solution has been to design reference sensors alongside the metabolite sensor to subtract the real baseline complicating the design of the sensor. Therefore, developing methods that do not rely solely on the electrical readout of the device while still benefiting from the CP properties and its mixed conductivity, can open new directions in molecular sensing in terms of specificity and sensitivity as well as provide straightforward paths toward their real-world implementation (A.-M. Pappa et al, 2018).…”

mentioning

confidence: 99%

A highly sensitive molecular structural probe applied to in situ biosensing of metabolites using PEDOT:PSS

Pappa²,

Pitsalidis³

et al. 2019

Biotech & Bioengineering

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A large amount of research within organic biosensors is dominated by organic electrochemical transistors (OECTs) that use conducting polymers such as poly(3,4‐ethylene dioxythiophene) doped with poly(styrenesulfonate) (PEDOT:PSS). Despite the recent advances in OECT‐based biosensors, the sensing is solely reliant on the amperometric detection of the bioanalytes. This is typically accompanied by large undesirable parasitic electrical signals from the electroactive components in the electrolyte. Herein, we present the use of in situ resonance Raman spectroscopy to probe subtle molecular structural changes of PEDOT:PSS associated with its doping level. We demonstrate how such doping level changes of PEDOT:PSS can be used, for the first time, on operational OECTs for sensitive and selective metabolite sensing while simultaneously performing amperometric detection of the analyte. We test the sensitivity by molecularly sensing a lowest glucose concentration of 0.02 mM in phosphate‐buffered saline solution. By changing the electrolyte to cell culture media, the selectivity of in situ resonance Raman spectroscopy is emphasized as it remains unaffected by other electroactive components in the electrolyte. The application of this molecular structural probe highlights the importance of developing biosensing probes that benefit from high sensitivity of the material's structural and electrical properties while being complimentary with the electronic methods of detection.

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“…Human body fluids (such as blood, sweat and tears) contain a large amount of chemical information, which indicates the deep state of biological molecules for human health . Biosensors can noninvasively detect analytes in biological fluids, providing a window for understanding the overall dynamic state of biological molecules in the human body . Among many biosensor interface materials, CPHs have shown great advantages due to its adaptability to immobilize biological recognition species and good biocompatibility originates from its similarity with extracellular matrix .…”

Section: Applications In Sensorsmentioning

confidence: 99%

Properties of conductive polymer hydrogels and their application in sensors

Guo

Pan

et al. 2019

J Polym Sci B Polym Phys

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Conductive polymer hydrogels (CPHs), which combine the unique advantages of hydrogels and organic conductors, have received wide attention due to their adjustable mechanical properties, biocompatibility, self‐healing, hydrophilicity, and ease of preparation. With doping engineering and incorporation with other functional nanomaterials, CPHs have exhibited excellent physical/chemical properties. CPHs have been widely used in various electronic devices, especially in the field of sensors due to its sensitivity to external stimuli. This review summarizes recent progress in CPHs from the aspect of the CPHs' properties and their application in advanced sensor technology. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019, 57, 1606–1621

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Organic Electronics for Point-of-Care Metabolite Monitoring

Cited by 113 publications

References 96 publications

Wearable Organic Electrochemical Transistor Patch for Multiplexed Sensing of Calcium and Ammonium Ions from Human Perspiration

Wearable Organic Electrochemical Transistor Patch for Multiplexed Sensing of Calcium and Ammonium Ions from Human Perspiration

A highly sensitive molecular structural probe applied to in situ biosensing of metabolites using PEDOT:PSS

Properties of conductive polymer hydrogels and their application in sensors

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