Highly Sensitive Gold Nanoparticles–DNA Nanosensor for γ-Radiation Detection

Abstract

It is very important to control the ionizing radiation dose in radiation therapy, which depends on the accurate and rapid measurement of radiation. Herein, a novel and highly sensitive nanosensor for γ-radiation detection is constructed using single-stranded DNA sequences as radiation-sensitive material and gold nanoparticles (AuNPs) as a signal reporter. Well-dispersed AuNPs gradually aggregated at high salt concentration when the sensor was irradiated, and this change was quantified by the visible spectra and surface plasmon resonance spectra. The radiation nanosensor has excellent linearity in the dose range of 0–100 Gy under optimal conditions. This method is simple and fast, which provides a new path for the γ-radiation dosimeter and has potential applications in the assessment of radiation-induced biological effects.

The effect of separate and combined action of lead oxide and gamma radiation on immunological reactivity and biochemical processes in the organs of immunogenesis

“…The development of oxidative stress in the spleen and liver was observed with the separate action of lead oxide, with the combined effect of lead oxide on the body irradiated with gamma rays in a small dose, the development of oxidative stress was observed in the spleen, there was no increase in the content of primary and secondary lipoperoxidation products in the liver. According to the state of LP and AD, it can be stated that the liver is more resistant to the separate and combined action of lead oxide in comparison with the spleen [34].…”

DNA-mediated assembly of a gold-nanoparticle film with controllable sonic behavior detected by novel electric-induced ultrasound

“…Recently, thiolated DNA functionalized GNPs (DNA-GNPs) with excellent programmability, molecular recognition and catalytic properties have been considered to be very promising platforms for biomedical applications, such as biosensing, 13 diagnostic intracellular probes 14 and gene regulation. 15 Interestingly, the thiolated DNA functionalized gold nanoparticles can be used as building blocks to establish multifunctional two-dimensional gold-assembled films through the sequence-specific interaction of DNA.…”

Radiation‐sensitive nanogel‐incorporated Fricke hydrogel dosimeters with reduced diffusion rates

“…3 The accurate dose verification is critical for tumor control and treatment quality assurance. 4 Nevertheless, it is challenging to utilize 2D detectors such as thin film dosimeters and semiconductor arrays for mapping the spatial dose distribution quickly and intuitively. Therefore, the development of high-performance three-dimensional (3D) dosimeters is of great significance.…”