Multifunctional capability and low coupling electronic skin (e-skin) is of great significance in advanced robot systems interacting with the human body or the external environment directly. Herein, a multifunctional e-skin system via vertical integrated different sensing materials and structures is presented. The multifunctional e-skin has capacity sensing the proximity, pressure, temperature, and relative humidity simultaneously, with scope of 100-0 mm, 0-30 N, 20-120 °C and 20-70%, respectively. The sensitivity of the four kinds of sensors can be achieved to 0.72 mm −1 , 16.34 N −1 , 0.0032 °C−1 , and 15.2 pF/%RH, respectively. The cross-coupling errors are less than 1.96%, 1.08%, 2.65%, and 1.64%, respectively, after temperature compensation. To be state-of-the-art, a commercial robot is accurately controlled via the multifunctional e-skin system in the complicated environment. The following and safety controlling exhibit both accuracy and high dynamic features. To improve the sensing performance to the insulating objects, machine learning is employed to classify the conductivity during the object approaching, leading to set the threshold in dynamic. The accuracy for isolating the insulator increases from 18% to 88%. Looking forward, the multifunctional e-skin system has broader applications in human-machine collaboration and industrial safety production technology.