Highly sensitive liquid chromatography–tandem mass spectrometry assay for the determination of azathioprine in presence of mercaptopurine and its application to a human pharmacokinetic study

Valluri, Venkat Rao; Katari, Naresh Kumar; Khatri, Chirag; Vyas, Govind; Polagani, Srinivasa Rao; Ponnam, Vijetha

doi:10.1002/sscp.202100022

Cited by 9 publications

(3 citation statements)

References 10 publications

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“…By inhibiting the expression of the PI3K/Akt pathways, withaferin A can stop A549 cells from proliferating and killing. 67,68 Radix ophiopogon japonicus contains the bioactive component ophiopogonin B. In NCI-H157 cells, ophiopogonin B suppressed Akt (Thr308, Ser473) phosphorylation, as well as other critical components of the PI3K/ Akt/mTOR signaling cascade, such as p-p70S6K (Thr389) and p-Akt (Thr308, Ser473).…”

Section: A Preclinical and In Vitro Studies On Pi3k/ Akt/mtor Inhibit...mentioning

confidence: 99%

PI3K/Akt/mTOR Pathways Inhibitors with Potential Prospects in Non-Small-Cell Lung Cancer

Alharbi

Samuel

Thangavelu

et al. 2022

J Environ Pathol Toxicol Oncol

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Lung cancer is the leading cause of cancer-related mortality across the globe. The most prevalent pathological form of lung cancer is non-small-cell lung cancer (NSCLC). Elevated stimulation of the PI3K/Akt/mTOR pathway causes a slew of cancer-related symptoms, making it a promising target for new anticancer drugs. The PI3K/Akt/mTOR path is involved extensively in carcinogenesis and disease advancement in NSCLC. Several new inhibitors targeting this pathway have been discovered in preclinical investigations and clinical trials. The etiology and epidemiology of NSCLC and biology of the PI3K/Akt/mTOR cascade and its role in NSCLC pathogenesis have all been discussed in this article. In this article, we've reviewed PI3K/Akt/mTOR cascade inhibitors that have been proven in vitro and in preclinical trials to be effective in NSCLC. Drugs targeting the PI3K/Akt/mTOR path in the treatment of NSCLC were also addressed. A better knowledge of the underlying molecular biology, including epigenetic changes, is also critical to detecting relevant biomarkers and guiding combination methods. Additionally, improved clinical trial designs will increase the capacity to test novel drugs and combinations for accounting for genomic variation and eventually improve patient outcomes.

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Section: A Preclinical and In Vitro Studies On Pi3k/ Akt/mtor Inhibit...mentioning

confidence: 99%

PI3K/Akt/mTOR Pathways Inhibitors with Potential Prospects in Non-Small-Cell Lung Cancer

Alharbi

Samuel

Thangavelu

et al. 2022

J Environ Pathol Toxicol Oncol

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“…Active chemicals derived from natural sources make up nutraceuticals that have nutrients with medicinal properties, capable of treating life‐threatening diseases such as hyperglycemia, carcinoma, blood‐related disorder, Cardiac disease, neuromuscular diseases, and neurodegenerative diseases. These serve as the foundation for future pharmaceutical formulations that will give maximum treatment effectiveness for treating various conditions while also assisting in a better lifestyle with fewer adverse effects (Fakhri et al, 2020; Valluri et al, 2021; Vyas et al, 2017). Here we will discuss nutraceuticals potentially combat L.C.…”

Section: Nutraceuticals Combating Lc Via Targeting the Nrf2/ho‐1 Sign...mentioning

confidence: 99%

The therapeutic role of nutraceuticals targeting the Nrf2/ HO ‐1 signaling pathway in liver cancer

Alharbi

Almalki

Albratty

et al. 2022

Journal of Food Biochemistry

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Liver cancer (L.C.) is the most common cause of cancer death in the United States and the fifth most common globally. The overexpression of nuclear factor E2 related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) caused by oxidative stress has been associated with tumor growth, aggressiveness, treatment resistance, and poor prognosis. Nutraceuticals that inhibit Nrf2/HO-1 signaling may become the most effective strategy to treat liver cancer. Phytochemicals found in fruits and vegetables, also known as nutraceuticals, tend to emerge as chemopreventive agents, with the added benefit of low toxicity and high nutritional values. This paper reviews the present scientific knowledge of the Nrf2/HO-1 signaling as a possible target molecule for chemotherapeutic agents, its basic control mechanisms, and Nrf2/HO-1 inducers produced from natural products that might be employed as cancer chemopreventive drugs. The growing interest in the contribution of the Nrf2/ARE/HO-1 signaling in the development of liver cancer and the Use of nutraceuticals to treat liver cancer by targeting Nrf2/ARE/HO-1.

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“…Currently, the increase in azathioprine (AP; IUPAC 6-[(1-methyl-4-nitro-1 H -imidazol-5-yl)thio]-9 H -purine) and its detection study are seen as very vital research prospects from the perspective of scientific, chemical, and biological development. − AP is a purine synthesis inhibitor that is also used as an immunosuppressive drug along with other medicines to deter organ transplantation rejection . AP is also utilized to treat autoimmune diseases like rheumatoid arthritis .…”

Section: Introductionmentioning

confidence: 99%

Rational Assembly of Polymer–Metal Coordination Hierarchical Superstructures for Azathioprine-Responsive Electrodes in Biological Samples

Mutharani

Ranganathan

Yang

et al. 2022

ACS Appl. Nano Mater.

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The sustainable self-assembly of small molecules into a superstructure is of prevalent interest for particle engineering and its applications. Herein, a ligand–metal cross-linking chemistry strategy is developed for the design of molybdenum–polydopamine (Mo–P x ) coordination flowers and their electrochemical sensing performance. The morphology of Mo–P x can be easily tuned by adding surfactants such as cetyltrimethylammonium bromide (CTAB) and sodium lauryl sulfate (SLS). This coordination polymerization is a rapid, single-step approach to producing functional materials and offers excellent control over the formation of flower-shaped superstructures. The devised Mo–P x (namely, x = H2O, CTAB, SLS) superstructures were applied as electrode materials to study the electrocatalytic activity of azathioprine (AP). Having the advantages of a hierarchical superstructure, including a great electroactive surface area, rapid electron transfer, interconnected nanosheet-based architectures, and Mo doping, the as-obtained Mo–PSLS served as a high-performance electrocatalyst in a AP sensor and unveiled great sensitivity (6.13 μA μM–1 cm–2), a low detection limit (3.5 nM), and good operational stability. Additionally, a Mo–PSLS-modified electrode was successfully utilized to monitor the AP concentration in actual rat blood serum samples with satisfactory recovery results. This work paves the way for the design of ligand–metal coordination complex superstructures for electrocatalyst-based applications.

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Highly sensitive liquid chromatography–tandem mass spectrometry assay for the determination of azathioprine in presence of mercaptopurine and its application to a human pharmacokinetic study

Cited by 9 publications

References 10 publications

PI3K/Akt/mTOR Pathways Inhibitors with Potential Prospects in Non-Small-Cell Lung Cancer

PI3K/Akt/mTOR Pathways Inhibitors with Potential Prospects in Non-Small-Cell Lung Cancer

The therapeutic role of nutraceuticals targeting the Nrf2/ HO ‐1 signaling pathway in liver cancer

Rational Assembly of Polymer–Metal Coordination Hierarchical Superstructures for Azathioprine-Responsive Electrodes in Biological Samples

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