Highly Spherical and Deformable Chitosan Microspheres for Arterial Embolization

Kang, Myung Joo; Park, Jung Min; Choi, Woo Sik; Lee, Jonghwi; Kwak, Byung Kook; Lee, Jaehwi

doi:10.1248/cpb.58.288

Cited by 19 publications

(5 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The final effect is a combination of the physical occlusion of the blood vessel and the local chemical action of the drug . Although many distinct materials have been used as embolic agents , poly(vinyl alcohol), commonly known as PVA, still remains as the most used material in embolization and chemoembolization procedures due to its intrinsic biocompatibility .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of spherical core-shell poly(vinyl acetate)/poly(vinyl alcohol) particles for use in vascular embolization: Study of morphological and molecular modifications during shell formation

et al. 2015

View full text Add to dashboard Cite

Transarterial vascular embolization and chemoembolization has become common medical procedures, where partially hydrolyzed poly(vinyl alcohol) (PVA) beads remains as one of the most used embolic agent materials. Although synthetic, PVA cannot be synthesized by direct polymerization and must be obtained by chemical modification of another polymer, usually poly(vinyl acetate) (PVAc). The aim of the present work is to synthesize spherical core‐shell PVAc/PVA particles and study the morphological and molecular modifications during shell formation. The polymer particles where produced in two stages, where first the PVAc core was obtained by suspension polymerization of vinyl acetate (VAc) and then the PVA shell synthesized through hydrolysis. Spherical PVAc particles were successfully produced and isolated using an optimized suspension polymerization process. During the shell formation, it was shown that none of the conditions used affected the overall morphology of the particles although changes in the final size distribution could be observed. However, it was possible to identify the process variables and reaction condition that affect the molecular weight averages and polydispersities of the final copolymer. POLYM. ENG. SCI., 55:2237–2244, 2015. © 2015 Society of Plastics Engineers

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis of spherical core-shell poly(vinyl acetate)/poly(vinyl alcohol) particles for use in vascular embolization: Study of morphological and molecular modifications during shell formation

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The hydrogels prepared from PEG are excellent biomaterials and its blend with other polymers may act as a pore former, to facilitate the creation of interconnected pore networks for increasing the cumulative release of the drug. However, increased pore creation might reduce the hindrance of pore networks, resulting in an increased burst effect with an elevated drug release. − The microspheres prepared from PEG are often used in combination with other polymers as the effective CR formulations , in addition to acting as a drug release modifier. − …”

Section: Introductionmentioning

confidence: 99%

Microspheres of Gelatin and Poly(ethylene glycol) Coated with Ethyl Cellulose for Controlled Release of Metronidazole

Phadke

Manjeshwar

Aminabhavi

2014

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

A novel type of metronidazole (MN) loaded ethyl cellulose (EC) coated blend microspheres of gelatin (GE) with poly(ethylene glycol) (PEG) were prepared by the water-in-oil (w/o) emulsion method and cross-linked with glutaraldehyde (GA) to achieve an encapsulation efficiency of 68%. The microspheres were characterized by Fourier transform infrared spectroscopy (FTIR) to understand the chemical interactions between the drug and the polymer matrix. Differential scanning calorimetry (DSC) was used to investigate the molecular level drug dispersion into the polymer matrix as well as surface coating onto the microspheres, while scanning electron microscopy (SEM) was employed to investigate the surface morphology. The diffusion coefficient, D v , and solvent front velocity, u, based on volume expansion of the microspheres were calculated from the dynamic swelling data of the matrixes to obtain insights into the transport phenomenon that showed a non-Fickian trend. In vitro release of MN was dependent on the extent of hydrophobic coating.

show abstract

“…In this background, Kang et al [25] focused on preparing deformable chitosan microspheres (CMs) for embolization by ionotropic gelation with polyethylene glycol (PEG). PEG was used as a porogen and was extracted later to form porous CMs, which made them overcome their rigidity.…”

Section: Diversity Of Chitosan-based Local Drug Deliverymentioning

confidence: 99%

Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics

et al. 2017

Self Cite

View full text Add to dashboard Cite

Chitosan has been widely used as a key biomaterial for the development of drug delivery systems intended to be administered via oral and parenteral routes. In particular, chitosan-based microparticles are the most frequently employed delivery system, along with specialized systems such as hydrogels, nanoparticles and thin films. Based on the progress made in chitosan-based drug delivery systems, the usefulness of chitosan has further expanded to anti-cancer chemoembolization, tissue engineering, and stem cell research. For instance, chitosan has been used to develop embolic materials designed to efficiently occlude the blood vessels by which the oxygen and nutrients are supplied. Indeed, it has been reported to be a promising embolic material. For better anti-cancer effect, embolic materials that can locally release anti-cancer drugs were proposed. In addition, a complex of radioactive materials and chitosan to be locally injected into the liver has been investigated as an efficient therapeutic tool for hepatocellular carcinoma. In line with this, a number of attempts have been explored to use chitosan-based carriers for the delivery of various agents, especially to the site of interest. Thus, in this work, studies where chitosan-based drug delivery systems have successfully been used for local delivery will be presented along with future perspectives.

show abstract

Highly Spherical and Deformable Chitosan Microspheres for Arterial Embolization

Cited by 19 publications

References 28 publications

Synthesis of spherical core-shell poly(vinyl acetate)/poly(vinyl alcohol) particles for use in vascular embolization: Study of morphological and molecular modifications during shell formation

Synthesis of spherical core-shell poly(vinyl acetate)/poly(vinyl alcohol) particles for use in vascular embolization: Study of morphological and molecular modifications during shell formation

Microspheres of Gelatin and Poly(ethylene glycol) Coated with Ethyl Cellulose for Controlled Release of Metronidazole

Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics

Contact Info

Product

Resources

About