Highly stable, love-mode surface acoustic wave biosensor using Au nanoparticle-MoS2-rGO nano-cluster doped polyimide nanocomposite for the selective detection of carcinoembryonic antigen

Jandas, P.J.; Luo, Jingting; Prabakaran, K.; Fu, Chen; Fu, Yong

doi:10.1016/j.matchemphys.2020.122800

Cited by 38 publications

(19 citation statements)

References 37 publications

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“…The results showed only an 8% performance decrease over the entire period. In a separate study conducted by the same group, [ 142 ] they further improved their Love mode SAW biosensor with a nanomaterial thin film bioreceptor to selectively detect CEA. The detection region of the SAW biosensor was coated with a nanomaterial cluster while the immobilization technique remained the same.…”

Section: Various Detection Application Of Saw Biosensorsmentioning

confidence: 99%

Current Trends on Surface Acoustic Wave Biosensors

Zida

Lin

Khung

2021

Adv Materials Technologies

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The development of rapid biosensing platforms is an integral part for the detection of many diseases, as well as important clinical biomarkers. So far, many new biosensing technologies have been described in literature but many of these novel platforms remain noncommercializable due to challenges in fabrication process, operational conditions as well as other cost concerns. Hence, there is a need to develop efficient and cost‐effective biosensing platforms and of the types available from literature, surface acoustic wave (SAW) biosensors have certain standout attributes. The simple manufacturing requirements of SAW‐based biosensor and its wide operating frequency range have produced promising outcome for bio‐detection and this has rendered this technological platform as a serious contender for point‐of‐care biosensor design. So far, SAW devices are reported for the detection of various bioactive targets of clinical importance and several designs are already commercialized. In this review, the latest development of SAW technologies in recent years for the detection of a broad range of biomolecules is presented and some of the challenges as well as potential future developments of SAW biosensors are highlighted.

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Section: Various Detection Application Of Saw Biosensorsmentioning

confidence: 99%

Current Trends on Surface Acoustic Wave Biosensors

Zida

Lin

Khung

2021

Adv Materials Technologies

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“…Recently, research findings have also highlighted the interest of materials such as recyclable polyethylene naphthalate associated with a SAW sensor for the detection of E. coli bacteria [103], or the association of a Love wave platform to the 2D composite rGO-MoS2 flakes synthetized with Au nanoparticles and the polyamic acid diethyl ethanolamine salt precursor for the carcinoembryonic antigen detection [104].…”

Section: A Acoustic Waves Based Platforms For Chemical and Bio Sensing And Monitoringmentioning

confidence: 99%

Passive Resonant Sensors: Trends and Future Prospects

et al. 2021

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Sensors based on "resonance phenomenon" span a broad spectrum of important current applications including detection of biological and chemical agents, and measurements of physical quantities. Resonance phenomena occur with all types of waves: electromagnetic, optic, and acoustic. This review reports about the most recent advances in the design and applications of resonant "passive" sensors, i.e. resonant sensors able to operate with a distant power source and/or able to communicate with a distant transceiver. The sensors considered in this review include acoustic, magnetoelastic, and electromagnetic transducers. They are presented through their relevant technological aspects and through they major advantages which include their integrability within embedded systems and/or systems requiring energy autonomy. Furthermore, the use of these resonant sensors is illustrated in a large variety of applications, ranging from environmental monitoring, structural health monitoring, food packaging monitoring, wearable or implanted sensors for the monitoring of physiological parameters in healthcare related applications, to IoT and future industry monitoring applications.

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“…Since biosensing is performed in liquid media, the ability to incorporate SAW-based devices with microfluidic channels, makes them a good choice for sensing biological entities in point of care applications [251]. The basic principle of operation involves functionalizing the delay line between IDTs, by coating with a sensitive layer, such as gold, graphene oxide, or single-layered graphene (SLG), which act as binding sites for the bioreceptors [55,214,252].…”

Section: Saw As Biosensors: Operating Principlementioning

confidence: 99%

“…The SAW biosensor with either a ST-quartz or LiTaO 3 substrate, has been reported for the detection of biomarkers for the early diagnosis of cancer, such as the carcinoembryonic antigen (CEA), prostate-specific membrane antigen (PSMA), epidermal growth factor (EGF), B-cell lymphoma, and exosomes [213,252,253,258,260,271,273,286].…”

Section: (I) Protein and Biomolecular Detectionmentioning

confidence: 99%

“…A Love mode SAW delay line biosensor using ST-cut quartz with Au IDT and sensing area operating at 120 MHz was reported, with an LOD of 0.31 ng/mL for CEA detection [287]. The same group subsequently reported a superior method for the formation of an anti-CEA antibody bioreceptor layer on the same SAW sensor, for the detection of CEA with an improved LOD of 0.084 ng/mL [252]. The anti-CEA antibody layer was immobilized on a conducting polymer coating with a graphene oxide (GO), MoS 2, Au nanoparticle (AuNP) cluster on the Au sensing area.…”

Section: (I) Protein and Biomolecular Detectionmentioning

confidence: 99%

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Acoustic Biosensors and Microfluidic Devices in the Decennium: Principles and Applications

Nair

Teo

2021

Micromachines

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Lab-on-a-chip (LOC) technology has gained primary attention in the past decade, where label-free biosensors and microfluidic actuation platforms are integrated to realize such LOC devices. Among the multitude of technologies that enables the successful integration of these two features, the piezoelectric acoustic wave method is best suited for handling biological samples due to biocompatibility, label-free and non-invasive properties. In this review paper, we present a study on the use of acoustic waves generated by piezoelectric materials in the area of label-free biosensors and microfluidic actuation towards the realization of LOC and POC devices. The categorization of acoustic wave technology into the bulk acoustic wave and surface acoustic wave has been considered with the inclusion of biological sample sensing and manipulation applications. This paper presents an approach with a comprehensive study on the fundamental operating principles of acoustic waves in biosensing and microfluidic actuation, acoustic wave modes suitable for sensing and actuation, piezoelectric materials used for acoustic wave generation, fabrication methods, and challenges in the use of acoustic wave modes in biosensing. Recent developments in the past decade, in various sensing potentialities of acoustic waves in a myriad of applications, including sensing of proteins, disease biomarkers, DNA, pathogenic microorganisms, acoustofluidic manipulation, and the sorting of biological samples such as cells, have been given primary focus. An insight into the future perspectives of real-time, label-free, and portable LOC devices utilizing acoustic waves is also presented. The developments in the field of thin-film piezoelectric materials, with the possibility of integrating sensing and actuation on a single platform utilizing the reversible property of smart piezoelectric materials, provide a step forward in the realization of monolithic integrated LOC and POC devices. Finally, the present paper highlights the key benefits and challenges in terms of commercialization, in the field of acoustic wave-based biosensors and actuation platforms.

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Highly stable, love-mode surface acoustic wave biosensor using Au nanoparticle-MoS2-rGO nano-cluster doped polyimide nanocomposite for the selective detection of carcinoembryonic antigen

Abstract: Highly stable, love-mode surface acoustic wave biosensor using Au nanoparticle-MoS2-rGO nano-cluster doped polyimide nanocomposite for the selective detection of carcinoembryonic antigen. Materials Chemistry and Physics, 246. p. 122800.

Cited by 38 publications

References 37 publications

Current Trends on Surface Acoustic Wave Biosensors

Current Trends on Surface Acoustic Wave Biosensors

Passive Resonant Sensors: Trends and Future Prospects

Acoustic Biosensors and Microfluidic Devices in the Decennium: Principles and Applications

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