HINT1 is involved in the behavioral abnormalities induced by social isolation rearing

Dang, Yonghui; Liu, Peng; Ma, Rui; Chu, Zheng; Liu, You‐Ping; Wang, Jiabei; Ma, Xiancang; Gao, Chengge

doi:10.1016/j.neulet.2015.08.026

Cited by 23 publications

(20 citation statements)

References 36 publications

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“…3. These results agree with what has been reported in the literatures that social isolation can lead to cognitive dysfunction in rodent models (Fone & Porkess, 2008; Dang et al, 2015). However, mechanism is still not clear.…”

Section: Discussionsupporting

confidence: 93%

Effects of social isolation and re-socialization on cognition and ADAR1 (p110) expression in mice

Chen

et al. 2016

PeerJ

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It has been reported that social isolation stress could be a key factor that leads to cognitive deficit for both humans and rodent models. However, detailed mechanisms are not yet clear. ADAR1 (Adenosine deaminase acting on RNA) is an enzyme involved in RNA editing that has a close relation to cognitive function. We have hypothesized that social isolation stress may impact the expression of ADAR1 in the brain of mice with cognitive deficit. To test our hypothesis, we evaluated the cognition ability of mice isolated for different durations (2, 4, and 8 weeks) using object recognition and object location tests; we also measured ADAR1 expression in hippocampus and cortex using immunohistochemistry and western blot. Our study showed that social isolation stress induced spatial and non-spatial cognition deficits of the tested mice. In addition, social isolation significantly increased both the immunoreactivity and protein expression of ADAR1 (p110) in the hippocampus and frontal cortex. Furthermore, re-socialization could not only recover the cognition deficits, but also bring ADAR1 (p110) immunoreactivity of hippocampus and frontal cortex, as well as ADAR1 (p110) protein expression of hippocampus back to the normal level for the isolated mice in adolescence. In conclusion, social isolation stress significantly increases ADAR1 (p110) expression in the hippocampus and frontal cortex of the mice with cognitive deficit. This finding may open a window to better understand the reasons (e.g., epigenetic change) that are responsible for social isolation-induced cognitive deficit and help the development of novel therapies for the resulted diseases.

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Section: Discussionsupporting

confidence: 93%

Effects of social isolation and re-socialization on cognition and ADAR1 (p110) expression in mice

Chen

et al. 2016

PeerJ

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“…The OFT showed the SI-rearing mice exhibited no difference in locomotion in a novel environment compared with GH mice, which was consistent with previous studies on mice [6, 12, 22]. Under such conditions, the increase of immobility time in the FST was considered as an effective screening test to evaluate the behavioral despair induced by SI-rearing [6].…”

Section: Discussionsupporting

confidence: 86%

“…The abnormal behaviors induced by SI-rearing include aggressive behavior [7], anxiety-like behavior [8], impairment of prepulse inhibition [9] and cognitive deficits [7]. Although some researchers failed to detect the obviously depression-like behavior in SI mice [10], it has been increasingly recognized nowadays [6, 11, 12]. …”

Section: Introductionmentioning

confidence: 99%

Antidepressant effect of recombinant NT4-NAP/AAV on social isolated mice through intranasal route

Liu

et al. 2016

Oncotarget

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The purpose of the present study was to observe the depression-like behavior induced by social isolation; detect the antidepressant effect of a recombinant adeno-associated virus (AAV) expressing NAP on social isolation mice by intranasal delivery. After construction of NT4-NAP/AAV, expression of NAP was confirmed in vitro. 3-week-old C57/BL mice were bred individually in cages as social isolation-rearing. Six weeks later, the first subset of mice underwent behavioral tests and western blot; the second was for enzyme-linked immunosorbent assay. NT4-NAP/AAV was delivered quaque die by nasal administration for consecutive 10 days before behavioral test. Several depression-like behaviors were observed in social isolation mice, including decreased relative sucrose preference, longer immobility time in forced swimming test, lower plasma corticosterone and decreased brain-derived neurotrophic factor in hippocampus. Thus, social isolation procedure appears to be an animal model of depression with good face and construct validity. What's more, the antidepressant effect in social isolation-rearing mice was observed after intranasal administration of NT4-NAP/AAV, suggesting that this might be a promising therapeutic strategy for depressive disorder.

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“…2,4 Social isolation also affects gene expression, negatively impacting vascular and mental health. 5,6 In view of these underlying mechanisms, it is not surprising that social isolation can substantially increase the risk for all-cause mortality. 7 …”

Section: Introductionmentioning

confidence: 99%

Social Media Use and Perceived Social Isolation Among Young Adults in the U.S.

Primack

Shensa

Sidani

et al. 2017

American Journal of Preventive Medicine

503

250

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Introduction Perceived social isolation (PSI) is associated with substantial morbidity and mortality. Social media platforms, commonly used by young adults, may offer an opportunity to ameliorate social isolation. This study assessed associations between social media use (SMU) and PSI among U.S. young adults. Methods Participants were a nationally representative sample of 1787 U.S. adults aged 19–32 years. They were recruited in October–November 2014 for a cross-sectional survey using a sampling frame that represented 97% of the U.S. population. SMU was assessed using both time and frequency of using 11 social media platforms, including Facebook, Twitter, Google+, YouTube, LinkedIn, Instagram, Pinterest, Tumblr, Vine, Snapchat, and Reddit. PSI was measured using the Patient-Reported Outcomes Measurement Information System scale. In 2015, ordered logistic regression was used to assess associations between SMU and SI while controlling for eight covariates. Results In fully adjusted multivariable models that included survey weights, compared with those in the lowest quartile for SMU time, participants in the highest quartile had twice the odds of having greater PSI (AOR=2.0, 95% CI=1.4, 2.8). Similarly, compared with those in the lowest quartile, those in the highest quartile of SMU frequency had more than three times the odds of having greater PSI (AOR=3.4, 95% CI=2.3, 5.1). Associations were linear (p<0.001 for all), and results were robust to all sensitivity analyses. Conclusions Young adults with high SMU seem to feel more socially isolated than their counterparts with lower SMU. Future research should focus on determining directionality and elucidating reasons for these associations.

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HINT1 is involved in the behavioral abnormalities induced by social isolation rearing

Cited by 23 publications

References 36 publications

Effects of social isolation and re-socialization on cognition and ADAR1 (p110) expression in mice

Effects of social isolation and re-socialization on cognition and ADAR1 (p110) expression in mice

Antidepressant effect of recombinant NT4-NAP/AAV on social isolated mice through intranasal route

Social Media Use and Perceived Social Isolation Among Young Adults in the U.S.

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