Hip Fracture in People with Erectile Dysfunction: A Nationwide Population-Based Cohort Study

Wu, Chieh‐Hsin; Tung, Yi‐Ching; Lin, Tzu‐Chieh; Chai, Chee‐Yin; Su, Yu-Feng; Tsai, Tai-Hsin; Tsai, Cheng-Yu; Lu, Ying‐Yi; Lin, Chih-Lung

doi:10.1371/journal.pone.0153467

Cited by 10 publications

(9 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, however, the Taiwan National Health Insurance program requires all insurance claims to be reviewed and audited by medical reimbursement specialists in the Bureau of National Health Insurance, which supports the validity and accuracy of the observed associations between osteoporosis and migraine. Furthermore, many studies have already used the NHIRD database because of its large size and long follow-up period (Chiu et al 2015 ; Chu et al 2015 ; Wu et al 2015 , 2016a , b , c , d ). A second limitation is that the NHIRD does not contain detailed data that can be used to identify osteoporosis risk factors such as exercise capacity, body mass index, smoking, alcohol consumption, and dietary habits.…”

Section: Discussionmentioning

confidence: 99%

Increased migraine risk in osteoporosis patients: a nationwide population-based study

Zhang

et al. 2016

SpringerPlus

Self Cite

View full text Add to dashboard Cite

Background: Osteoporosis and migraine are both important public health problems and may have overlapping pathophysiological mechanisms. The aim of this study was to use a Taiwanese population-based dataset to assess migraine risk in osteoporosis patients. Methods:The Taiwan National Health Insurance Research Database was used to analyse data for 40,672 patients aged ≥20 years who had been diagnosed with osteoporosis during 1996-2010. An additional 40,672 age-matched patients without osteoporosis were randomly selected as the non-osteoporosis group. The relationship between osteoporosis and migraine risk was estimated using Cox proportional hazard regression models.Results: During the follow-up period, 1110 patients with osteoporosis and 750 patients without osteoporosis developed migraine. After controlling for covariates, the overall incidence of migraine was 1.37-fold higher in the osteoporosis group than in the non-osteoporosis group (3.72 vs. 1.24 per 1000 person-years, respectively). Migraine risk factors included high Charlson Comorbidity Index score, female gender, hypertension, depression, asthma, allergic rhinitis, obesity, and tobacco use disorder. Conclusions:Our results indicate that patients with a history of osteoporosis had a higher risk of migraine.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased migraine risk in osteoporosis patients: a nationwide population-based study

Zhang

et al. 2016

SpringerPlus

Self Cite

View full text Add to dashboard Cite

show abstract

“…The mandatory health insurance programme, Taiwan National Health Insurance (NHI) project, is the only payer system launched on 1 March 1995, which covers nearly 99% of the 23.74 million Taiwan residents 14 15. The National Health Research Institutes created the NHIRD for medical research.…”

Section: Methodsmentioning

confidence: 99%

Stroke and osteoporosis: a Taiwan cohort study

Zhang

et al. 2020

Postgraduate Medical Journal

Self Cite

View full text Add to dashboard Cite

BackgroundOsteoporosis and stroke are major health problems that have potentially overlapping pathophysiological mechanisms. The aim of this study was to estimate osteoporosis risk in Taiwan patientswho had a stroke.MethodThis study retrieved data contained in the Taiwan National Health Insurance Research Database for a population-based sample of consecutive patients either hospitalised for stroke or treated for stroke on an outpatient basis. A total of 7550 newly diagnosed patientswho had a stroke were enrolled during 1996–2010. Osteoporosis risk in these patients was then compared with a matched group of patients who had not had a stroke randomly selected from the database at a ratio of 1:4 (n=30 200). The relationship between stroke history and osteoporosis risk was estimated with Cox proportional hazard regression models.ResultsDuring the follow-up period, osteoporosis developed in 1537 patients who had a stroke and in 5830 patients who had not had a stroke. The incidence of osteoporosis for cohorts with and without stroke was 32.97 and 14.28 per 1000 person-years, respectively. After controlling for covariates, the overall risk of osteoporosis was 1.82-fold higher in the stroke group than in the non-stroke group. The relative osteoporosis risk contributed by stroke had apparently greater impact among male gender and younger age groups.ConclusionHistory of stroke is a risk factor for osteoporosis in Taiwan. Much attention to stroke-targeted treatment modalities might minimise adverse outcomes of osteoporosis.

show abstract

“…Furthermore, ∼47% of men age >50 y have osteopenia (34). There are also strong associations among erectile dysfunction, reduced BMD, and increased risk of hip fracture (47,48). Thus, our data hold considerable promise for the cotherapy of erectile dysfunction and bone loss in aging men.…”

Section: Discussionmentioning

confidence: 56%

Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass

Kim

Taneja

Perez-Pena

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

We report that two widely-used drugs for erectile dysfunction, tadalafil and vardenafil, trigger bone gain in mice through a combination of anabolic and antiresorptive actions on the skeleton. Both drugs were found to enhance osteoblastic bone formation in vivo using a unique gene footprint and to inhibit osteoclast formation. The target enzyme, phosphodiesterase 5A (PDE5A), was found to be expressed in mouse and human bone as well as in specific brain regions, namely the locus coeruleus, raphe pallidus, and paraventricular nucleus of the hypothalamus. Localization of PDE5A in sympathetic neurons was confirmed by coimmunolabeling with dopamine β-hydroxylase, as well as by retrograde bone-brain tracing using a sympathetic nerve-specific pseudorabies virus, PRV152. Both drugs elicited an antianabolic sympathetic imprint in osteoblasts, but with net bone gain. Unlike in humans, in whom vardenafil is more potent than tadalafil, the relative potencies were reversed with respect to their osteoprotective actions in mice. Structural modeling revealed a higher binding energy of tadalafil to mouse PDE5A compared with vardenafil, due to steric clashes of vardenafil with a single methionine residue at position 806 in mouse PDE5A. Collectively, our findings suggest that a balance between peripheral and central actions of PDE5A inhibitors on bone formation together with their antiresorptive actions specify the osteoprotective action of PDE5A blockade.

show abstract

Hip Fracture in People with Erectile Dysfunction: A Nationwide Population-Based Cohort Study

Cited by 10 publications

References 54 publications

Increased migraine risk in osteoporosis patients: a nationwide population-based study

Increased migraine risk in osteoporosis patients: a nationwide population-based study

Stroke and osteoporosis: a Taiwan cohort study

Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass

Contact Info

Product

Resources

About