2018
DOI: 10.14238/sp20.2.2018.115-22
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Hiperbilirubinemia pada neonatus >35 minggu di Indonesia; pemeriksaan dan tatalaksana terkini

Abstract: Pada bayi baru lahir terjadi kenaikan fisiologis kadar bilirubin dan 60% bayi >35 minggu akan terlihat ikterik. Namun, 3%-5% dari kejadian ikterik tersebut tidaklah fisiologis dan berisiko untuk terjadinya kerusakan neurologis bahkan kematian. Sebagai pencegahan hiperbilirubinemia berat yang dapat menyebabkan kerusakan neurologis, pemeriksaan bilirubin telah menjadi rekomendasi universal bayi baru lahir yang terlihat kuning. Semakin tinggi perhatian klinisi untuk pencegahan kernikterus, semakin rendah insid… Show more

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Cited by 8 publications
(10 citation statements)
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“…Aside from prematurity, genetic polymorphisms have been reported as an important factor in the development of SNNJ [46]. The most commonly-studied gene is the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) that is closely associated with Crigler-Najjar’s syndrome type I and II, and Gilberts syndrome.…”
Section: Introductionmentioning
confidence: 99%
“…Aside from prematurity, genetic polymorphisms have been reported as an important factor in the development of SNNJ [46]. The most commonly-studied gene is the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) that is closely associated with Crigler-Najjar’s syndrome type I and II, and Gilberts syndrome.…”
Section: Introductionmentioning
confidence: 99%
“…Neonatal jaundice can occur in LBW either pre-term or term gestational age [17,23]. This occurs because the liver function is not optimal, there is a protein deficiency that plays a role in the transport of neonatal bilirubin, namely albumin and Y protein or ligandin, causing deposition of bilirubin in blood.…”
Section: Resultsmentioning
confidence: 99%
“…Gross motor and fine motor skills Hyperbilirubinemia is an excess of bilirubin levels in the blood of more than 10 mg% in the first week which results in jaundice, a yellow color that is clearly visible in the skin, mucosa, sclera and urine, and other organs, whereas in normal infants the total serum bilirubin level is 5 mg% (Sembiring, 2019). Bilirubin levels will increase after birth, then settle and then decrease after the age of 7 days (Rohsiswatmo & Amandito, 2018). Pathologically the baby will experience jaundice throughout the body or grades three to five with bilirubin levels (> 12 mg/dl) this condition is indicated for phototherapy, if bilirubin levels are > 20 mg/dl then the baby is indicated for exchange transfusion.…”
Section: Introductionmentioning
confidence: 99%
“…There are as many as 6.6% of infants died in Indonesia due to neonatal jaundice (Kemenkes RI, 2015). As many as 3%-5% of neonates who have pathological hyperbilirubinemia are at high risk of developing kernicterus (Rohsiswatmo & Amandito, 2018). The incidence of jaundice in term infants in some hospitals is quite high, ranging from 13.7% to 85%.…”
Section: Introductionmentioning
confidence: 99%