Hiperhomocisteinemia. Panorama actual y contribución del ratón a su estudio

Nuño-Ayala, Mario; Carnicer, Ricardo; Guzmán, Mario; Guillén, Natalía; Navarro, María Á.; Arnal, Carmen; Osada, Jesús

doi:10.1016/j.arteri.2010.04.008

Cited by 2 publications

(2 citation statements)

References 229 publications

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“…Acquired HHcy may result from lifestyle factors, clinical conditions, and medications. Renal insufficiency and certain medications, including folate antagonists, carbamazepine, nitric oxide, methotrexate, cholestyramine, and niacin, contribute to acquired HHcy [ 4 , 10 , 19 ]. Acquired forms may remain asymptomatic until the third or fourth decade of life, manifesting as thrombotic events.…”

Section: Types Of Hyperhomocysteinemias (Hhcy)mentioning

confidence: 99%

“…Recurrent severe vascular occlusions are a principal complication of HHcy, with even a moderate elevation in blood Hcy contributing independently to vascular diseases. Hcy serves as an atherogenic risk predictor and potent prognostic indicator for adverse cardiovascular events [19][20][21]39], emphasizing the clinical significance of HHcy and the importance of interventions to mitigate the risks and improve the outcomes [18]. Clinical suspicion arises with moderately elevated (31-100 µmol/L) or severe (>100 µmol/L) Hcy levels, and a definitive diagnosis involves identifying mutations in the CβS gene [40].…”

Section: Clinical Manifestations Of Hhcymentioning

confidence: 99%

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Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition

González-Lamuño,

Arrieta-Blanco,

Fuentes

et al. 2023

Nutrients

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Hyperhomocysteinemia (HHcy) is recognized as an independent risk factor for various significant medical conditions, yet controversy persists around its assessment and management. The diagnosis of disorders afffecting homocysteine (Hcy) metabolism faces delays due to insufficient awareness of its clinical presentation and unique biochemical characteristics. In cases of arterial or venous thrombotic vascular events, particularly with other comorbidities, it is crucial to consider moderate to severe HHcy. A nutritional approach to HHcy management involves implementing dietary strategies and targeted supplementation, emphasizing key nutrients like vitamin B6, B12, and folate that are crucial for Hcy conversion. Adequate intake of these vitamins, along with betaine supplementation, supports Hcy remethylation. Lifestyle modifications, such as smoking cessation and regular physical activity, complement the nutritional approach to enhance Hcy metabolism. For individuals with HHcy, maintaining a plasma Hcy concentration below 50 μmol/L consistently is vital to lowering the risk of vascular events. Collaboration with healthcare professionals and dietitians is essential for developing personalized dietary plans addressing the specific needs and underlying health conditions. This integrated approach aims to optimize metabolic processes and reduce the associated health risks.

show abstract

Section: Types Of Hyperhomocysteinemias (Hhcy)mentioning

confidence: 99%

Section: Clinical Manifestations Of Hhcymentioning

confidence: 99%

Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition

González-Lamuño,

Arrieta-Blanco,

Fuentes

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition

González-Lamuño,

Blanco,

Fuentes

et al. 2023

Preprint

View full text Add to dashboard Cite

Hyperhomocysteinemia (HHcys) is recognized as an independent risk factor for various significant medical conditions, yet controversy persists around its assessment and management. The diagnosis of disorders affecting homocysteine (Hcys) metabolism faces delays due to insufficient awareness of its clinical presentation and unique biochemical characteristics. In cases of arterial or venous thrombotic vascular events, particularly with other comorbidities, it is crucial to consider moderate to severe HHcys. A nutritional approach to HHcys management involves implementing dietary strategies and targeted supplementation, emphasizing key nutrients like vitamin B6, B12, and folate crucial for Hcys conversion. Adequate intake of these vitamins, along with betaine supplementation, supports Hcys remethylation. Lifestyle modifications, such as smoking cessation and regular physical activity, complement the nutritional approach to enhance Hcys metabolism. For individuals with HHcys, maintaining a plasma Hcys concentration below 50 μmol/L consistently is vital to lower the risk of vascular events. Collaboration with healthcare professionals and dietitians is essential for developing personalized dietary plans addressing specific needs and underlying health conditions. This integrated approach aims to optimize metabolic processes and reduce the associated health risks.

show abstract

Hiperhomocisteinemia. Panorama actual y contribución del ratón a su estudio

Cited by 2 publications

References 229 publications

Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition

Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition

Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition

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