Hiperparatiroidismo secundario en el cáncer de próstata avanzado

Flores, S. Quirosa; Varsavsky, Mariela; Guardia, Francisco Valle Díaz de la; Ortiz, José Luis Miján; Muñóz-Torres, Manuel; Álvarez, Enrique Raya; Gómez, Armando Zuluaga

doi:10.1016/j.endonu.2010.01.013

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…The osteoanabolic effect of PTH after intermittent application can also be seen in bone metastasis of cancers like prostate cancer [18]. It is well possible, that after PTH substitution not only the healthy bone cells (osteoblasts) but also the pathologic cancer metastasis cells in bone can be activated [19].…”

Section: Discussionmentioning

confidence: 99%

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Effect of parathyroid hormone on hypogonadism induced bone loss of proximal femur of orchiectomized rat

et al. 2011

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PurposeManagement of hypogonadism-induced osteoporosis in elderly men is still a challenge. We investigated the short-term effects of parathyroid hormone (PTH) treatments on strength, micro-architecture, and mineral density of trochanteric region of orchiectomized rat femur.MethodsEight-month-old male Sprague–Dawley rats (n = 44) were divided into two groups: (1) orchiectomized (ORX) and (2) sham group. Twelve weeks after orchiectomy, half of the orchiectomized animals were treated with daily subcutaneously injected PTH (0.040 mg/kg/BW) (ORX-PTH) for 5 weeks. The other half remained untreated (ORX). The sham-operated group was divided and treated in the same way (sham, sham-PTH). After 5 weeks, both femurs were excised for biomechanical and histomorphometric analysis, trabecular measurements, mineral content assessment, and immunofluorescence analysis.ResultsThe femoral trochanteric strength after PTH treatment was enhanced in the breaking test (ORX-Fmax = 158.7 N vs. ORX + PTH-Fmax = 202 N). Stiffness of treated ORX animals reached nearly the levels observed in untreated sham rats. PTH therapy improved the trabecular connectivity, width, and area (ORX-Tb.Ar = 47.79% vs. ORX + PTH-Tb.Ar = 68.47%, P < 0.05) in the proximal femur. The treated rats showed significantly improved mineral content in ashed femurs (ORX-mineral content = 43.73% vs. ORX + PTH-mineral content = 49.49%) when compared to the untreated animals. A comparison of widths of fluorescence bands in cortical bone of the subtrochanteric cross-sections showed a significant increase in oppositions after the PTH therapy.ConclusionsOur finding supports the hypothesis that PTH therapy seems to be a rational therapy in patients with hypogonadism induced bone loss and improves the bone strength of trochanteric region of rat femur.

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Section: Discussionmentioning

confidence: 99%

“…This fact maybe limits the use of PTH in such cases [18]. Here is the pre-therapeutic staging und evaluation of bone metastasis must be performed.…”

Section: Discussionmentioning

confidence: 99%

Effect of parathyroid hormone on hypogonadism induced bone loss of proximal femur of orchiectomized rat

et al. 2011

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Sunlight, Vitamin D and Prostate Cancer Epidemiology

Schwartz

2011

Vitamin D

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Parathyroid hormone is associated with prostate cancer

Kim

Bang

Seo

et al. 2020

Prostate International

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Background The present study investigated the association of serum parathyroid hormone (PTH), vitamin D, and calcium levels with prostate cancer (CaP). Methods The study population consisted of an experimental group [459 patients including 216 patients with CaP and 243 patients with benign prostate hyperplasia (BPH)] and a prostatectomy group (47 patients who underwent radical prostatectomy). Patients with serum creatinine levels >1.4 mg/dl, parathyroid disease, and/or PTH levels <10 pg/ml were excluded. Patients with CaP and patients with BPH were compared, and the correlation between serum parameters and clinical data was determined. Preoperative and postoperative PTH levels were compared in the prostatectomy group. Results Mean PTH levels were 41.67 ± 28.82 and 27.06 ± 17.32 pg/ml in the CaP and BPH groups, respectively ( p < 0.001). When patients were divided into two groups as per prostate-specific antigen levels (≤20 or >20 ng/ml), Gleason score (≤7 or ≥8), and stage (≤T3 or ≥ T4), there was no significant difference in PTH levels between the two groups. Mean postoperative PTH levels (26.93 ± 13.58 pg/ml) were significantly lower than preoperative PTH levels (36.71 ± 21.04 pg/ml) in the same patients who underwent radical prostatectomy. Conclusion Serum PTH levels were higher in patients with CaP than in patients with BPH and decreased significantly after radical prostatectomy. The present results suggest an association between serum PTH and CaP. Further large cohort studies are necessary to validate the present data.

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Hiperparatiroidismo secundario en el cáncer de próstata avanzado

Cited by 4 publications

References 21 publications

Effect of parathyroid hormone on hypogonadism induced bone loss of proximal femur of orchiectomized rat

Effect of parathyroid hormone on hypogonadism induced bone loss of proximal femur of orchiectomized rat

Sunlight, Vitamin D and Prostate Cancer Epidemiology

Parathyroid hormone is associated with prostate cancer

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