Hiperuricemia no lúpus eritematoso sistêmico: está associada a manifestações neuropsiquiátricas da doença?

Sheikh, Mahdi; Movassaghi, Shafieh; Khaledi, Mohammad; Moghaddassi, Maryam

doi:10.1016/j.rbr.2015.05.002

Cited by 12 publications

(2 citation statements)

References 22 publications

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“…[15,16,22] Previous studies focused on clinical onset patients with hyperuricemia or a combination of other complications. [3–5,23–25] Nevertheless, our research attempts to elucidate possible pathological alterations in asymptomatic young patients with primary hyperuricemia, with an emphasis on oxidative stress and inflammation. Hyperuricemia is a metabolic disease related to habits, customs, age, gender, and inherited factors, and hyperuricemia is also correlated with obesity, hypertension, diabetes, renal failure, dyslipidemia, and liver diseases.…”

Section: Discussionmentioning

confidence: 99%

Relationship between oxidative stress and inflammation in hyperuricemia

Zhou

Zhao²,

Pu³

et al. 2018

Medicine

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The average age of hyperuricemia patients has gradually decreased, but young patients with primary hyperuricemia often do not exhibit clinical symptoms and have not received sufficient attention. However, a lack of symptoms with primary hyperuricemia does not mean that high serum uric acid (UA) levels cannot lead to pathological effects, such as oxidative stress and inflammation, and the specific damage is still unclear. We aimed to determine the relationship between oxidative stress and inflammation to explore the possible role of pathological damage in asymptomatic young patients with primary hyperuricemia.A total of 333 participants were enrolled in our study: 158 asymptomatic young patients with primary hyperuricemia and 175 healthy persons from a health check-up population. Malondialdehyde (MDA), superoxide dismutase (SOD), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and general biochemical markers were measured.We found no differences in biochemical markers (fasting glucose, TG, TC, LDL-C, HDL-C, SCr, BUN, AST, and ALT) between the patients and healthy persons. Subsequent analyses of oxidative stress and inflammation revealed that the serum levels of MDA, IL-6, and TNF-α in the patients were significantly higher than those in the healthy control group (P < .001), and the SOD activity was significantly lower (P < .001). As the UA levels increased, MDA increased significantly and SOD decreased significantly; likewise, IL-6 and TNF-α increased significantly as the UA level increased. MDA showed a significant positive correlation with IL-6 (r = 0.367, P < .001) and TNF-α (r = 0.319, P < .001), and SOD was negatively correlated with IL-6 (r = −0.241, P < .01) and TNF-α (r = −0.308, P < .001). Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698–3.286, P < .001; OR: 3.261, 95% CI: 1.729–3.857, P < .001; for IL-6 and TNF-α, respectively) and MDA (OR: 1.836, 95% CI: 1.283–2.517, P < .01; OR: 2.532, 95% CI: 1.693–3.102, P < .001; for IL-6 and TNF-α, respectively) were risk factors for high IL-6 and TNF-α and that SOD (OR: 0.517, 95% CI: 0.428–0.763, P < .01; OR: 0.603, 95% CI: 0.415–0.699, P < .001; for IL-6 and TNF-α, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Therefore, we should pay more attention to the pathological damage caused by these alterations.

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Section: Discussionmentioning

confidence: 99%

Relationship between oxidative stress and inflammation in hyperuricemia

Zhou

Zhao²,

Pu³

et al. 2018

Medicine

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“…In a Brazilian study developed with 204 patients, a significant association of hyperuricemia with stroke (OR 2.38; 95%CI 1.2-7.24), SAH (OR 7.76; 95%CI 2.72-15.76), hyperlipidemia (OR 5.05; 95%CI 1.59-11.32), peripheral neuropathy (OR 3.49; 95%CI 1.52-12.23), and arterial thrombosis (OR 4.95; 95%CI 1.98-15.34) was observed 14 .…”

Section: Discussionmentioning

confidence: 99%

Association between hyperuricemia and hypertension: a case-control study

Bezerra

Santos-Veloso

et al. 2021

Rev. Assoc. Med. Bras.

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OBJECTIVE:The aim of this study was to evaluate the association between hyperuricemia and systemic arterial hypertension.METHODS: This was a case-control study where individuals aged >18 years were included, who were divided into hypertensive and nonhypertensive groups, excluding those with incomplete information in medical records or with the chronic kidney disease epidemiology collaboration <60 mL/min/1.73 m³. Systemic arterial hypertension was categorized as a dependent variable, while the independent variables were hyperuricemia (i.e., primary variable), sex, education, the practice of physical activity, alcoholism, smoking, diabetes mellitus, chronic kidney disease, a family history of systemic arterial hypertension, age, isolated hyperlipidemia, and mixed hyperlipidemia. Statistical analysis included the univariate and multivariate data analysis, performed by adjusting the logistic regression models using the software R (R Core Team [2018]).RESULTS: Out of 103 patients evaluated, 75 patients were included in this study. In hypertensive patients, hyperuricemia was more frequent (p=0.029), being present in 18.9% individuals. In the univariate analysis, a statistically significant association was found between hyperuricemia and systemic arterial hypertension (OR 10.9; 95%CI 1.29-1420.0; p=0.023); however, in the multivariate analysis, when adjustment was made for age, the only control variable that persisted in the model, this association ceased to be significant (OR 8.5; 95%CI 0.87-1157.0; p=0.070).CONCLUSIONS: There was no independent association between hyperuricemia and systemic arterial hypertension. The latter was associated with diabetes mellitus, chronic kidney disease, and age.

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Serum uric acid levels contribute to new renal damage in systemic lupus erythematosus patients

et al. 2017

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This study aims to determine whether uric acid levels contribute to new renal damage in systemic lupus erythematosus (SLE) patients. This prospective study was conducted in consecutive patients seen since 2012. Patients had a baseline visit and follow-up visits every 6 months. Patients with ≥2 visits were included; those with end-stage renal disease (regardless of dialysis or transplantation) were excluded. Renal damage was ascertained using the SLICC/ACR damage index (SDI). Univariable and multivariable Cox-regression models were performed to determine the risk of new renal damage. Uric acid was included as a continuous and dichotomous (per receiving operating characteristic curve) variable. Multivariable models were adjusted for age at diagnosis, disease duration, socioeconomic status, SLEDAI, SDI, serum creatinine, baseline use of prednisone, antimalarials, and immunosuppressive drugs. One hundred and eighty-six patients were evaluated; their mean (SD) age at diagnosis was 36.8 (13.7) years; nearly all patients were mestizo. Disease duration was 7.7 (6.8) years. Follow-up time was 2.3 (1.1) years. The SLEDAI was 5.2 (4.3) and the SDI 0.8 (1.1). Uric acid levels were 4.5 (1.3) mg/dl. During follow-up, 16 (8.6%) patients developed at least one new point in the renal domain of the SDI. In multivariable analyses, uric acid levels (continuous and dichotomous) at baseline predicted the development of new renal damage (HR 3.21 (1.39-7.42), p 0.006; HR 18.28 (2.80-119.48), p 0.002; respectively). Higher uric acid levels contribute to the development of new renal damage in SLE patients independent of other well-known risk factors for such occurrence.

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Hiperuricemia no lúpus eritematoso sistêmico: está associada a manifestações neuropsiquiátricas da doença?

Cited by 12 publications

References 22 publications

Relationship between oxidative stress and inflammation in hyperuricemia

Relationship between oxidative stress and inflammation in hyperuricemia

Association between hyperuricemia and hypertension: a case-control study

Serum uric acid levels contribute to new renal damage in systemic lupus erythematosus patients

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