Hippocampal CA3-region is crucial for acquisition and memory consolidation in Morris water maze task in mice

Florian, Cédrick; Roullet, Pascal

doi:10.1016/j.bbr.2004.03.003

Cited by 131 publications

(104 citation statements)

References 39 publications

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“…Water maze task. The procedure consisted of three different phases: a familiarization phase, a training phase, and a probe test (45). To distinguish between short-and long-term memory in this case as well, different time intervals were used between the last training session and the probe test.…”

Section: Methodsmentioning

confidence: 99%

Ventral striatal plasticity and spatial memory

Ferretti

Roullet

Sargolini

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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Spatial memory formation is a dynamic process requiring a series of cellular and molecular steps, such as gene expression and protein translation, leading to morphological changes that have been envisaged as the structural bases for the engram. Despite the role suggested for medial temporal lobe plasticity in spatial memory, recent behavioral observations implicate specific components of the striatal complex in spatial information processing. However, the potential occurrence of neural plasticity within this structure after spatial learning has never been investigated. In this study we demonstrate that blockade of cAMP response element binding protein-induced transcription or inhibition of protein synthesis or extracellular proteolytic activity in the ventral striatum impairs longterm spatial memory. These findings demonstrate that, in the ventral striatum, similarly to what happens in the hippocampus, several key molecular events crucial for the expression of neural plasticity are required in the early stages of spatial memory formation. T he formation of long-term memories is believed to involve a dynamic process by which a labile memory is progressively converted into a more stable and potentially permanent trace. Evidence for such a time-dependent process comes from studies demonstrating that electroconvulsive shock produces amnesia only if delivered shortly after learning, whereas the same treatment is ineffective when delivered several hours later (1). Long-term memory is accompanied by changes in neuronal morphology and connectivity, and these alterations are thought to be essential for the stabile encoding of new information (2). This transformation has been suggested to depend upon plastic changes that involve a sequence of specific and coordinated cellular processes. These begin with neurotransmitter receptor activation that induces shortterm changes in synaptic efficacy based on receptor phosphorylation and trafficking (3, 4). Subsequently, alterations in gene expression and protein synthesis occur that are the basis for longterm structural modifications (5, 6).A key issue in the study of memory in vertebrates is the brain site at which these processes occur. Clinical evidence in humans suggests that structures within the medial temporal lobe (MTL) play a prominent role in long-term memories. MTL lesions induce profound deficits in the formation of long-lasting declarative memories while sparing the acquisition of nondeclarative memories such as visual-motor skills (7,8). Such findings suggest that the hippocampus might be an essential site where plasticity occurs in the initial steps of declarative memory stabilization. Accordingly, those molecular events thought to be crucial for the long-term encoding of memories such as regulation of gene expression and protein synthesis, as well as structural changes, have been described in the hippocampus after spatial learning (6, 9, 10).Recent experimental evidence, however, demonstrates that structures different from the hippocampus might also be involved in ...

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Section: Methodsmentioning

confidence: 99%

Ventral striatal plasticity and spatial memory

Ferretti

Roullet

Sargolini

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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“…The apparatus and protocol for evaluating spatial memory were the same as in previous experiments (Florian and Roullet 2004). Briefly, mice were trained in the spatial Morris water maze (110 cm in diameter).…”

Section: Behavioral Testingmentioning

confidence: 99%

Characterization of spatial memory reconsolidation

Jaeger¹,

Courtey²,

Brus³

et al. 2014

Learn. Mem.

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Reconsolidation is necessary for the restabilization of reactivated memory traces. However, experimental parameters have been suggested as boundary conditions for this process. Here we investigated the role of a spatial memory trace's age, strength, and update on the reconsolidation process in mice. We first found that protein synthesis is necessary for reconsolidation to occur in the hippocampal CA3 region after reactivation of partially acquired and old memories but not for strongly acquired and recent memories. We also demonstrated that the update of a previously stable memory required, again, a memory reconsolidation in the hippocampal CA3. Finally, we found that the reactivation of a strongly acquired memory requires an activation of the anterior cingulate cortex as soon as 24 h after acquisition. This study demonstrates the importance of the knowledge of the task on the dynamic nature of memory reconsolidation processing.

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“…However, the CA3 region seems to contribute to acquisition of spatial tasks involving multiple trials. CA3 lesioned rats are impaired in acquisition of the standard MWM task, object-place and odourplace paired associate learning, all of which are tasks that require multiple trials to learn [29,55,74].…”

Section: Ca3 Region-autoassociative System: Encoding Versus Retrievalmentioning

confidence: 99%

“…Accordingly, GBE seems to have an effect on acquisition and short-term working memory, but not retrieval of long-term memory of previously acquired tasks [94,183]. Therefore, it is likely that the observed behavioural effects related to GBE are dependent on CA3 region of the hippocampus, as CA3 has been shown to be critical during learning/acquisition of spatial information, but not necessarily involved in long-term recall of previously acquired information in both RAM and MWM tasks [29,55,116,117,201]. In support of this, GBE has been shown to markedly improve the performance of both young and aged animals in repeated reversal spatial learning tests (MWM), suggesting that it aids acquisition of rapid learning tasks [94,219], something which is also dependent on the CA3 recurrent network [141].…”

Section: An Overviewmentioning

confidence: 99%

The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms

et al. 2009

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Emerging evidence suggests that a group of dietary-derived phytochemicals known as flavonoids are able to induce improvements in memory, learning and cognition. Flavonoids have been shown to modulate critical neuronal signalling pathways involved in processes of memory, and therefore are likely to affect synaptic plasticity and long-term potentiation mechanisms, widely considered to provide a basis for memory. Animal dietary supplementation studies have further shown that flavonoidrich foods are able to reverse age-related spatial memory and spatial learning impairments. A more accurate understanding of how a particular spatial memory task works and of which aspects of memory and learning can be assessed in each case, are necessary for a correct interpretation of data relating to diet-cognition experiments. Further understanding of how specific behavioural tasks relate to the functioning of hippocampal circuitry during learning processes might be also elucidative of the specific observed memory improvements. The overall goal of this review is to give an overview of how the hippocampal circuitry operates as a memory system during behavioural tasks, which we believe will provide a new insight into the underlying mechanisms of the action of flavonoids on cognition.

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Hippocampal CA3-region is crucial for acquisition and memory consolidation in Morris water maze task in mice

Cited by 131 publications

References 39 publications

Ventral striatal plasticity and spatial memory

Ventral striatal plasticity and spatial memory

Characterization of spatial memory reconsolidation

The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms

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