Hippocampal involvement in working memory encoding of changing locations: An fMRI study

Toepper, Max; Markowitsch, Hans J.; Gebhardt, Helge; Beblo, Thomas; Thomas, Christine; Gallhofer, Bernd; Drießen, Martin; Sammer, Gebhard

doi:10.1016/j.brainres.2010.07.065

Cited by 51 publications

(49 citation statements)

References 43 publications

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“…Lesion studies on humans also showed that patients with medial temporal lobe damages had WM impairment (Ezzyat and Olson, 2008;Olson et al, 2006a,b). Functional MRI studies confirmed that the hippocampus was recruited for WM processing (Davachi and Wagner, 2002;Faraco et al, 2010;Karlsgodt et al, 2005;Toepper et al, 2010), and that hippocampal activation was significantly correlated with WM performance (Berent-Spillson et al, 2010;McGettigan et al, 2011) and/or WM response time (Bokde et al, 2010). Finally, a neural network study reported that the hippocampus was included in a network underlying the maintenance of WM (Gazzaley et al, 2004), suggesting a functional contribution of the hippocampus to WM.…”

Section: Introductionmentioning

confidence: 78%

The NTSR1 gene modulates the association between hippocampal structure and working memory performance

Jin¹,

Lei²,

Wang³

et al. 2013

NeuroImage

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The genetic and neural basis of working memory (WM) has been extensively studied. Many dopamine (DA) related genes, including the NTSR1 gene (a DA modulator gene), have been reported to be associated with WM performance. The NTSR1 protein is predominantly expressed in the cerebral cortex and the hippocampus, the latter of which is closely involved in WM processing based on both lesion and fMRI studies. Thus far, however, no study has examined the joint effects of NTSR1 gene polymorphism and hippocampal morphology on WM performance. Participants of the current study were 330 healthy Chinese college students. WM performance was measured with a 2-back WM paradigm. Structural MRI data were acquired and then analyzed using an automated procedure with atlas-based FreeSurfer segmentation software (v 4.5.0) package. Linear regression analyses were conducted with a NTSR1 C/T polymorphism which was previously reported to be associated with WM (rs4334545), hippocampal volume, and their interaction as predictors of WM performance, with gender and intracranial volume (ICV) as covariates. Results showed a significant interaction between NTSR1 genotype and hippocampal volume (p b .05 for both the left and right hippocampi). Further analysis showed that the correlation between hippocampal volume and WM scores was significant for carriers of the NTSR1 T-allele (p b .05 for both hippocampi), but not for CC homozygotes. These results indicate that the association between hippocampal structure and WM performance was modulated by variation in the NTSR1 gene, and suggest that further studies of brain-behavior associations should take genetic background information into account.

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Section: Introductionmentioning

confidence: 78%

The NTSR1 gene modulates the association between hippocampal structure and working memory performance

Jin¹,

Lei²,

Wang³

et al. 2013

NeuroImage

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“…It is, therefore, interesting that some recent studies involving complex visual stimuli, such as faces and photographs of scenes, have reported MTL activity in association with short-delay recognition memory tasks (Mitchell et al 2000;Ranganath and D'Esposito 2001;Stern et al 2001;Schon et al 2004Schon et al , 2009Schon et al , 2010Nichols et al 2006;Piekema et al 2006Piekema et al , 2009Axmacher et al 2007;Hannula and Ranganath 2008;Olsen et al 2009;Lee and Rudebeck 2010;Toepper et al 2010). In this section, we consider findings like these and their possible interpretation.…”

Section: Mtl Activity In Imaging Tasks Involving Short Delaysmentioning

confidence: 87%

Working memory, long-term memory, and medial temporal lobe function

Jeneson¹,

Squire²

2011

Learn. Mem.

313

250

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Early studies of memory-impaired patients with medial temporal lobe (MTL) damage led to the view that the hippocampus and related MTL structures are involved in the formation of long-term memory and that immediate memory and working memory are independent of these structures. This traditional idea has recently been revisited. Impaired performance in patients with MTL lesions on tasks with short retention intervals, or no retention interval, and neuroimaging findings with similar tasks have been interpreted to mean that the MTL is sometimes needed for working memory and possibly even for visual perception itself. We present a reappraisal of this interpretation. Our main conclusion is that, if the material to be learned exceeds working memory capacity, if the material is difficult to rehearse, or if attention is diverted, performance depends on long-term memory even when the retention interval is brief. This fundamental notion is better captured by the terms subspan memory and supraspan memory than by the terms short-term memory and long-term memory. We propose methods for determining when performance on short-delay tasks must depend on long-term (supraspan) memory and suggest that MTL lesions impair performance only when immediate memory and working memory are insufficient to support performance. In neuroimaging studies, MTL activity during encoding is influenced by the memory load and correlates positively with long-term retention of the material that was presented. The most parsimonious and consistent interpretation of all the data is that subspan memoranda are supported by immediate memory and working memory and are independent of the MTL.

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“…Despite the fact that hippocampal formation is involved in spatial working memory (e.g. in Corsi Block-Tapping test), no reliable working memory impairment could be detected in HS patients with either a leftor right-sided focus [40,73]. Studies using the ROCF test to evaluate memory deficits in epilepsy patients concluded that the ROCF test lacks the sensitivity to measure right temporal lobe function due to the possibility for verbalization of many of its components [74,75].…”

Section: Discussionmentioning

confidence: 99%

Correlation between calbindin expression in granule cells of the resected hippocampal dentate gyrus and verbal memory in temporal lobe epilepsy

Karádi

Janszky

Gyimesi

et al. 2012

Epilepsy & Behavior

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Hippocampal involvement in working memory encoding of changing locations: An fMRI study

Cited by 51 publications

References 43 publications

The NTSR1 gene modulates the association between hippocampal structure and working memory performance

The NTSR1 gene modulates the association between hippocampal structure and working memory performance

Working memory, long-term memory, and medial temporal lobe function

Correlation between calbindin expression in granule cells of the resected hippocampal dentate gyrus and verbal memory in temporal lobe epilepsy

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