Hippocampal metabolic dysfunction in juvenile myoclonic epilepsy: 3D multivoxel spectroscopy study

Ristić, Aleksandar J.; Ostojić, Jelena; Kozić, Duško; Vojvodić, Nikola; Popovic, Ljubica; Janković, Srdja; Baščarević, Vladimir; Sokić, Dragoslav

doi:10.1016/j.jns.2010.12.022

Cited by 17 publications

(18 citation statements)

References 24 publications

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“…Lower NAA/Cr was observed with advancing age and duration of epilepsy, regardless of seizure frequency and AED therapy in frontal cortex and thalamus [53]. A recent MR spectroscopy study of the hippocampal region has found the neurobiochemical abnormalities in patients with JME [31].…”

Section: Neuro-radiological Investigationsmentioning

confidence: 95%

“…As executive functions involve complex cognitive processes that require coordination of several subsystems, cognitive impairment in naming, verbal, and visual memory could also be explained by this network dysfunction [20]. Recently, Ristic´et al [31] found a significant difference in metabolite ratios of both hippocampi between the JME and the control group. They suggested that altered hippocampal metabolism could be a consequence of propagation of epileptiform discharges typically generated in fronto-temporal thalamo-cortical circuits.…”

Section: Cognitive Disorders In Jmementioning

confidence: 99%

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Frontal lobe dysfunctions in patients with juvenile myoclonic epilepsy

Jović

2015

J Pediatr Epilepsy

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Juvenile myoclonic epilepsy (JME) is a common form of idiopathic generalized epilepsy. Behavioral and cognitive problems are frequently observed in JME. Although the underlying mechanisms are still unknown, recent neuropsychological and neuroimaging studies provide strong evidence for frontal lobe dysfunction. Neuropsychological studies have shown JME patients to be impaired in a number of executive functions such as concept formation, abstract reasoning, mental flexibility, and cognitive speed and planning. They scored below average on measures of attention, immediate verbal memory, working memory, and verbal fluency. The patients with JME performed worse than the group with temporal lobe epilepsy on some frontal tasks. Some specific personality features, such as unreliability and emotional instability, poor social adjustment, high rates of anxiety, mood disorders, phobias and somatization disorders seen in patients with JME have also been described in patients with frontal lobe-lesions. Quantitative magnetic resonance imaging studies have shown regional, frontal cortical and thalamic grey matter abnormalities. These findings support the pathophysiological concept of functional abnormalities in the thalamo-cortical circuit in JME. The additional impact of interictal epileptiform electroencephalography activity on cognitive functions was suggested. Poor working memory and impaired executive and motor performance in JME patients may also be attributed to altered dopamine signaling in the striatum and frontal lobes. JME may be a non-uniform condition. Different genetic and pathophysiologic mechanisms could underlie the clinically observed differences in prognosis, cognitive functioning, personality traits, and frontal lobe deficits.

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Section: Neuro-radiological Investigationsmentioning

confidence: 95%

Section: Cognitive Disorders In Jmementioning

confidence: 99%

Frontal lobe dysfunctions in patients with juvenile myoclonic epilepsy

Jović

2015

J Pediatr Epilepsy

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“…An emphasis on abnormal function in the frontal lobe of JME patients Seizure 30 (2015) [124][125][126][127][128][129][130][131] was reinforced by findings from neuropsychological testing [8] and EEG analyses [9], but several recent studies have also identified extra-frontal, focal cortical, and regional abnormalities [4,10]. Several volumetry and MRS studies revealed the hippocampal structural changes in JME, that suggest the hippocampus has important role in JME patient [11,12].…”

Section: Introductionmentioning

confidence: 99%

Extrafrontal structural changes in juvenile myoclonic epilepsy: A topographic analysis of combined structural and microstructural brain imaging

Kim

Lim

Kim

et al. 2015

Seizure

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In addition to structural changes in the thalamofrontal system, there was a conspicuous alteration of WM diffusivity in widespread extra-frontal areas and an associated decreased GM thickness in temporoparietal regions, including a significant reduction of hippocampal volume. These findings suggest that the pathophysiology of JME may be not confined to the thalamofrontal circuit but may also involve extensive areas of the extra-frontal network which encompasses temporo-parietal regions.

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“…A 0.2% incidence of coexistent focal and primary generalised epilepsy was reported in a group of patients hospitalised at the Cleveland Clinic Epilepsy Monitoring Unit (Jeha et al, 2006). Decreased cortical thickness in temporal regions in JME patients (Tae et al, 2008) and hippocampal metabolic dysfunction using a 3D multivoxel spectroscopy study (Ristic et al, 2011) in patients with JME were reported. Usui et al studied 26 patients with JME who had seizures recorded during video-EEG monitoring and found that 14 patients (54%) had focal semiological or EEG features, or both (Usui et al, 2005).…”

Section: Discussionmentioning

confidence: 98%

Focal epilepsy recruiting a generalised network of juvenile myoclonic epilepsy: a case report

Khaing

Lim

Tan

2014

Epileptic Disorders

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We report a patient with juvenile myoclonic epilepsy who subsequently developed temporal lobe epilepsy, which gradually became clinically dominant. Video telemetry revealed both myoclonic seizures and temporal lobe seizures. The temporal lobe seizures were accompanied by a focal recruiting rhythm with rapid generalisation on EEG, in which the ictal EEG pattern during the secondary generalised phase was morphologically similar to the ictal pattern during myoclonic seizures. The secondary generalised seizures of the focal epilepsy responded to sodium valproate, similar to the myoclonic epilepsy. In this rare case of coexistent Juvenile Myoclonic Epilepsy and Temporal lobe epilepsy, the possibility of focal epilepsy recruiting a generalised epileptic network was proposed and discussed.

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Hippocampal metabolic dysfunction in juvenile myoclonic epilepsy: 3D multivoxel spectroscopy study

Cited by 17 publications

References 24 publications

Frontal lobe dysfunctions in patients with juvenile myoclonic epilepsy

Frontal lobe dysfunctions in patients with juvenile myoclonic epilepsy

Extrafrontal structural changes in juvenile myoclonic epilepsy: A topographic analysis of combined structural and microstructural brain imaging

Focal epilepsy recruiting a generalised network of juvenile myoclonic epilepsy: a case report

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