Hippocampal spatial view cells for memory and navigation, and their underlying connectivity in humans

Rolls, Edmund T.

doi:10.1002/hipo.23467

Cited by 57 publications

(97 citation statements)

References 373 publications

(1,028 reference statements)

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“…Consistent with the above evidence that Group 2 is involved in navigation, area 31 which receives from POS1 and POS2 is implicated by neuroimaging in representing heading direction (Baumann & Mattingley, 2021 ). Consistent with the concept that navigation and executive function are performed to achieve goals, this part of the posterior cingulate and medial parietal cortex (31a, 23d, and PCV) receives from the reward‐related medial orbitofrontal cortex and pregenual anterior cingulate cortex (Figure 2 ; Grabenhorst & Rolls, 2011 ; Rolls, 2022a , 2022b ; Rolls et al, 2020 , 2022e ).…”

Section: Discussionmentioning

confidence: 54%

“…Further, POS1 and POS2 also have effective connectivity to the medial parahippocampal gyrus PHA1‐3 regions (corresponding to TH) where scenes are represented (Epstein, 2005 , 2008 ; Epstein & Baker, 2019 ; Epstein & Julian, 2013 ; Epstein & Kanwisher, 1998 ; Kamps et al, 2016 ; Natu et al, 2021 ; Rolls, 2022b ; Sulpizio et al, 2020 ), and with the hippocampal system (Figure 2 ). POS1 and POS2 may thus be involved in scene representations reaching the hippocampal system, and are likely to contribute to the activation of hippocampal spatial view cells, and thereby be involved in providing information important in episodic memory and navigation (Rolls, 2022b ; Rolls & Wirth, 2018 ). POS1 and POS2 are also likely to be involved in memory and navigation by providing inputs to other members of the Group 2 regions as follows.…”

Section: Discussionmentioning

confidence: 99%

“…Buckner & DiNicola, 2019 ; Dastjerdi et al, 2011 ; Foster et al, 2012 , 2013 ; Fox et al, 2018 ). Spatial roles for this part of the PCC are emphasized too by the connectivity with superior parietal areas 7Am and 7Pm, parts of dorsal stream processing which are implicated in visuo‐motor spatial functions (Orban et al, 2021 ; Rolls et al, 2022a , 2022d ; Snyder et al, 1998 ) and coordinate transforms from egocentric eye‐based frames to allocentric world‐based frames suitable for idiothetic update of hippocampal spatial representations (Rolls, 2020 , 2021b , 2022b ; Snyder et al, 1998 ). Consistent with this, a cingulate sulcus visual area has been described that responds selectively to visual and vestibular cues to self‐motion (Smith et al, 2018 ), and this may be according to Figure S1 in or near 23d.…”

Section: Discussionmentioning

confidence: 99%

“…The Group 3 regions thus appear to be involved in relatively low‐level visual processing, with connectivity with the superior parietal cortex area 7 which suggests that the Group 3 regions are involved in visuo‐motor control appropriate for motor actions in visual space (Andersen, 1995 ; Huang & Sereno, 2018 ; Orban et al, 2021 ; Rolls et al, 2022a , 2022d ; Urgen & Orban, 2021 ), and perhaps in the necessary spatial coordinate transforms (Rolls, 2020 ; Salinas & Sejnowski, 2001 ). Indeed, spatial coordinate transforms are also necessary for idiothetic update of spatial representations useful for hippocampal function including navigation when the spatial view is obscured (Dean & Platt, 2006 ; Rolls, 2020 , 2021b , 2022b ; Snyder et al, 1998 ; Vedder et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

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The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation

Rolls

Wirth

Deco

et al. 2022

Human Brain Mapping

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The human posterior cingulate, retrosplenial, and medial parietal cortex are involved in memory and navigation. The functional anatomy underlying these cognitive functions was investigated by measuring the effective connectivity of these Posterior Cingulate Division (PCD) regions in the Human Connectome Project-MMP1 atlas in 171 HCP participants, and complemented with functional connectivity and diffusion tractography. First, the postero-ventral parts of the PCD (31pd, 31pv, 7m, d23ab, and v23ab) have effective connectivity with the temporal pole, inferior temporal visual cortex, cortex in the superior temporal sulcus implicated in auditory and semantic processing, with the reward-related vmPFC and pregenual anterior cingulate cortex, with the inferior parietal cortex, and with the hippocampal system. This connectivity implicates it in hippocampal episodic memory, providing routes for "what," reward and semantic schema-related information to access the hippocampus. Second, the antero-dorsal parts of the PCD (especially 31a and 23d, PCV, and also RSC) have connectivity with early visual cortical areas including those that represent spatial scenes, with the superior parietal cortex, with the pregenual anterior cingulate cortex, and with the hippocampal system. This connectivity implicates it in the "where" component for hippocampal episodic memory and for spatial navigation. The dorsal-

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation

Rolls

Wirth

Deco

et al. 2022

Human Brain Mapping

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“…The postcentral gyrus and connected insula and inferior and medial parietal cortex regions are involved in somatosensory processing and representing actions in space [69][70][71]. The hippocampal regions are involved in memory [72][73][74]. The orbitofrontal and anterior cingulate cortex are involved in emotion [75,76].…”

Section: Discussionmentioning

confidence: 99%

Lower gestational age is associated with lower cortical volume and cognitive and educational performance in adolescence

Wang

Rolls

et al. 2022

BMC Med

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Background Gestational age (GA) is associated with later cognition and behavior. However, it is unclear how specific cognitive domains and brain structural development varies with the stepwise change of gestational duration. Methods This large-scale longitudinal cohort study analyzed 11,878 early adolescents’ brain volume maps at 9–10 years (baseline) and 5685 at 11–12 years (a 2-year follow-up) from the Adolescent Brain Cognitive Development (ABCD) study. According to gestational age, adolescents were divided into five categorical groups: ≤ 33 weeks, 34–35 weeks, 36 weeks, 37–39 weeks, and ≥ 40 weeks. The NIH Toolbox was used to estimate neurocognitive performance, including crystallized and fluid intelligence, which was measured for 11,878 adolescents at baseline with crystallized intelligence and relevant subscales obtained at 2-year follow-up (with participant numbers ranging from 6185 to 6310 depending on the cognitive domain). An additional large population-based cohort of 618,070 middle adolescents at ninth-grade (15–16 years) from the Danish national register was utilized to validate the association between gestational age and academic achievements. A linear mixed model was used to examine the group differences between gestational age and neurocognitive performance, school achievements, and grey matter volume. A mediation analysis was performed to examine whether brain structural volumes mediated the association between GA and neurocognition, followed with a longitudinal analysis to track the changes. Results Significant group differences were found in all neurocognitive scores, school achievements, and twenty-five cortical regional volumes (P < 0.05, Bonferroni corrected). Specifically, lower gestational ages were associated with graded lower cognition and school achievements and with smaller brain volumes of the fronto-parieto-temporal, fusiform, cingulate, insula, postcentral, hippocampal, thalamic, and pallidal regions. These lower brain volumes mediated the association between gestational age and cognitive function (P = 1 × 10−8, β = 0.017, 95% CI: 0.007–0.028). Longitudinal analysis showed that compared to full term adolescents, preterm adolescents still had smaller brain volumes and crystallized intelligence scores at 11–12 years. Conclusions These results emphasize the relationships between gestational age at birth and adolescents’ lower brain volume, and lower cognitive and educational performance, measured many years later when 9–10 and 11–12 years old. The study indicates the importance of early screening and close follow-up for neurocognitive and behavioral development for children and adolescents born with gestational ages that are even a little lower than full term.

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Selective Brain Activations and Connectivities Related to the Storage and Recall of Human Object‐Location, Reward‐Location, and Word‐Pair Episodic Memories

Rolls,

Zhang,

Deco

et al. 2024

Human Brain Mapping

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Different cortical systems to the hippocampus were activated using fMRI during different types of episodic memory task. For object with scene location episodic memory, the activations were high in cortical systems involved in spatial processing, including the ventromedial visual and medial parahippocampal system. These activations for the medial parahippocampal system were higher in the right hemisphere. The activations in the face and object processing ventrolateral visual cortical stream regions FFC, PIT, V8 and TE2p were higher in the object‐location in scene task than the reward‐location task, and were higher in the right hemisphere. For reward‐location in scene episodic memory, activations were also high in the ventromedial visual cortical spatial stream to the hippocampus, but were also selectively high in storage in key reward cortical regions (ventromedial prefrontal 10r, 10v, 10d; pregenual anterior cingulate d32, p24, p32, s32; and medial orbitofrontal cortex reward‐related pOFC, 11l, OFC). For word‐pair episodic memory, activations were lower in the ventromedial visual and medial parahippocampal spatial cortical stream, and were higher in language‐related regions in Broca's area (44, 45, 47l), and were higher in the left hemisphere for these regions and for the many highly connected inferior frontal gyrus regions in the left hemisphere. Further, effective connectivity analyses during the episodic memory tasks showed that the direction of connectivity for these systems was from early visual cortical regions V2–V4 to the ventromedial visual cortical regions VMV1–3 and VVC for spatial scene processing; was from the pregenual anterior cingulate and orbitofrontal cortex reward systems to the hippocampal system; and was from the FFC/V8/PIT system to TE2p in the visual inferior temporal visual cortex, which has connectivity to lateral parahippocampal TF, which in turn has forward effective connectivity to the hippocampus.

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Hippocampal spatial view cells for memory and navigation, and their underlying connectivity in humans

Cited by 57 publications

References 373 publications

The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation

The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation

Lower gestational age is associated with lower cortical volume and cognitive and educational performance in adolescence

Selective Brain Activations and Connectivities Related to the Storage and Recall of Human Object‐Location, Reward‐Location, and Word‐Pair Episodic Memories

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