Histamine as an autocrine growth factor: an unusual role for a widespread mediator

Rivera, Elena; Cricco, G.; Engel, Nora; Fitzsimons, Carlos P.; Martin, G. Saint; Bergoc, Rosa

doi:10.1006/scbi.2000.0303

Cited by 78 publications

(72 citation statements)

References 51 publications

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“…Although still controversial, several studies identified H 1 and/or H 2 receptor expression in cancer cells and showed that histamine functions as a growth factor (Rivera et al, 2000). In our system, histamine exerts an autonomous effect on cell growth and potentiates chemokine-induced cell proliferation.…”

Section: Discussionmentioning

confidence: 79%

Mast cells have a protumorigenic role in human thyroid cancer

et al. 2010

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In different human carcinoma types, mast cell infiltrate increases with respect to normal tissue and mast cell density correlates with a bad prognosis. To assess the role of mast cells in human thyroid cancer, we compared the density of tryptase-positive mast cells in 96 papillary thyroid carcinomas (PTCs) versus normal thyroid tissue from 14 healthy individuals. Mast cell density was higher in 95% of PTCs (n ¼ 91) than in control tissue. Mast cell infiltrate correlated with extrathyroidal extension (P ¼ 0.0005) of PTCs. We show that thyroid cancer cell-line-derived soluble factors induce mast cell activation and chemoattraction in vitro. Different mast cell lines (HMC-1 and LAD2) and primary human lung mast cells induced thyroid cancer cell invasive ability, survival and DNA synthesis in vitro. The latter effect was mainly mediated by three mast-cell-derived mediators: histamine, and chemokines CXCL1/GROa and CXCL10/IP10. We show that xenografts of thyroid carcinoma cells (8505-C) could recruit mast cells injected into the tail vein of mice. Co-injection of human mast cells accelerated the growth of thyroid cancer cell (8505-C) xenografts in athymic mice. This effect was mediated by increased tumor vascularization and proliferation, and was reverted by treating mice with sodium cromoglycate (Cromolyn), a specific mast cell inhibitor. In conclusion, our study data suggest that mast cells are recruited into thyroid carcinomas and promote proliferation, survival and invasive ability of cancer cells, thereby contributing to thyroid carcinoma growth and invasiveness.

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Section: Discussionmentioning

confidence: 79%

Mast cells have a protumorigenic role in human thyroid cancer

et al. 2010

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“…In these tumors, histamine behaves as an autocrine growth factor inducing proliferation via H2R and the in vivo treatment with H2R antagonists resulted in a very significant tumor regression. 5,22 However, the clinical trials performed with histamine H2R antagonists exhibited no encouraging results for breast cancer patients. 42 In the present study, we demonstrate a highly significant correlation between H3R expression and proliferation and, furthermore, its association with histamine production, reflecting the importance of H3R in the development of breast carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5] In mammary gland, histamine plays a critical role in growth regulation, differentiation and functioning during development, pregnancy and lactation. [6][7][8] Histamine is a biogenic amine involved in the regulation of different physiological processes.…”

Section: Introductionmentioning

confidence: 99%

“…[9][10][11][12] High histamine biosynthesis and content has been reported in different human neoplasias including breast cancer, as well as in experimental tumors induced in rodents. 5,[13][14][15] We have previously reported that H1R and H2R are present in different normal and malignant cell lines and benign lesions and tumors derived from human mammary gland. [16][17][18][19][20] Furthermore, in experimental mammary carcinomas, histamine becomes an autocrine growth factor capable of regulating cell proliferation via H1R and H2R.…”

Section: Introductionmentioning

confidence: 99%

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The role of histamine in human mammary carcinogenesis: H3 and H4 receptors as potential therapeutic targets for breast cancer treatment.

Medina¹,

Croci²,

Crescenti³

et al. 2008

Cancer Biology & Therapy

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108

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There is increasing evidence that describes a histamine role in normal and cancer cell proliferation. To better understand the importance of histamine in breast cancer development, the expression of histamine H3 (H3R) and H4 (H4R) receptors and their association with proliferating cell nuclear antigen (PCNA), histidine decarboxylase (HDC) and histamine content were explored in mammary biopsies. Additionally, we investigated whether H3R and

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“…Bodis J's study found that histamine could directly stimulate the steroid production of ovarial granulosa cells [33]. Histamine is also recognized as an autocrine growth factor [34,35], which influences the secretion of various growth factors and cytokines in human body [36][37][38]. What is more interesting, histamine could induce ovulation in the isolated perfused ovary [39].…”

Section: Discussionmentioning

confidence: 99%

HDC gene polymorphisms are associated with age at natural menopause in Caucasian women

Zhang

Xiong

Wang

et al. 2006

Biochemical and Biophysical Research Communications

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Histidine decarboxylase gene (HDC) encodes histidine decarboxylase which is the crucial enzyme for the biosynthesis of histidine. Studies have shown that histamine is likely to be involved in the regulation of reproduction system. To find the possible correlation between HDC gene and AANM (age at natural menopause), we selected 265 postmenopausal women from 131 nuclear families and performed a transmission disequilibrium test. Significant within-family associations with AANM for SNP rs854163 and SNP rs854158 of HDC gene were observed (P values = 0.0018 and 0.0197, respectively). After 1000 permutations, SNP rs854163 still remained significant within-family association with AANM. Consistently, we also detected a significant within-family association between haplotype block 2 (defined by SNP rs854163 and rs860526) and AANM in the haplotype analyses (P value = 0.0397). Our results suggest that the HDC gene polymorphisms are significantly associated with AANM in Caucasian women. KeywordsHDC; Association; Age at natural menopause; SNP Menopause status is one important anthropological variable influencing the overall health of women, especially those in advanced ages. Abnormal low age at natural menopause (AANM) correlates with female infertility due to ovarian aging [1]. Early menopause was also reported to be associated with the increased risks of fracture [2,3], coronary heart disease [4,5], and disorders of the central nervous system [6,7]. In addition, the Caucasian women with menopause ages of about 40-44 years have 4% higher risk of mortality than those with menopause ages of about 50-54 years [8].There is a wide variation in AANM, varying between 40 and 60 years. Extensive studies have been conducted to search for the predictors of AANM. Some lifestyle factors were reported to be associated with AANM, such as obesity, smoking, alcohol consumption, and breastfeeding [9][10][11]. However, these lifestyle factors just accounted for a small part of the large variation in AANM [12]. Additionally, genetic factors were found to play an important role in the variation of AANM. Family study showed that the menopausal ages of daughters were significantly correlated with mothers' [13]. Heritability estimates of AANM ranged from 0.63 to 0.87, suggesting a strong genetic control [14][15][16]. To date, the exact genes involved remain unknown, though some candidate genes underlying AANM have been proposed, such as ESR1 (estrogen receptor alpha), CYP1B1 (cytochrome P450, family 1, subfamily B, poly-peptide 1), Factor V Leiden, and FMR1 (fragile X mental retardation 1) [17][18][19][20].Histidine decarboxylase (HDC) gene encodes histidine decarboxylase, which is the crucial enzyme for synthesis of histamine in human body. As an important bioactive substance, histamine is crucial to various physiological activities [21]. It has been found that histamine directly stimulated the secretion of GnRH (gonadotropin-releasing hormone), which is the key molecule in the regulation of gonadal hormone release [22]. Furthermore, st...

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Histamine as an autocrine growth factor: an unusual role for a widespread mediator

Cited by 78 publications

References 51 publications

Mast cells have a protumorigenic role in human thyroid cancer

Mast cells have a protumorigenic role in human thyroid cancer

The role of histamine in human mammary carcinogenesis: H3 and H4 receptors as potential therapeutic targets for breast cancer treatment.

HDC gene polymorphisms are associated with age at natural menopause in Caucasian women

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