Histamine modulates salivary secretion and diminishes the progression of periodontal disease in rat experimental periodontitis

Abstract

Histamine is able to reduce periodontitis-induced damage to SMG and bone structure.

Programmed cell death in periodontitis: recent advances and future perspectives

“…The percentage of apoptotic cells in the salivary glands was enhanced in rats with ligature‐induced periodontitis as compared to that in the control rats (Nakamura‐Kiyama et al , ). Histamine reduces cell apoptosis (Deng et al , ), and accordingly, periodontitis‐induced increase in the proportion of apoptotic cells in rat submandibular gland (SMG) could be reduced by histamine treatment (Prestifilippo et al , ). Apoptosis in SMG might also be induced by depleted level of oxidative stress (OS) markers in the serum of patients with periodontitis (Ekuni et al , ).…”

Pharmacological targeting of histamine H4 receptor in periodontal disease

“…It is important to highlight that previously reported data paradoxically showed similar improvements of periodontal disease employing subcutaneous histamine at low concentration (0.1 mg/kg), indicating that other histamine receptor subtype could also be involved in periodontal healthiness (Prestifilippo et al , ).…”

“…The evidence presented showed that 2 weeks of EP produced a considerable decrease in SMG salivary secretion, indicating that SMG functionality is severely altered and suggesting the development of anatomical and/or mechanistic alterations under this pathological condition. Accordingly, we previously reported that EP caused a marked reduction in the capacity of SMG to secrete saliva in response to cholinergic stimulation (Amer et al , ; Prestifilippo et al , ). The inhibitory effect on salivation induced by periodontitis was partially prevented by subcutaneously administered JNJ7777120 treatment.…”

“…Immunohistochemical studies were performed as previously reported (Prestifilippo et al , ; Martinel Lamas et al , ), employing mouse anti‐proliferating cell nuclear antigen (PCNA, 1:100, Dako Cytomation, Glostrup, Denmark) or rabbit anti‐aquaporin 5 (AQP5, 1:50, Abcam, Cambridge, MA, USA) antibodies. Apoptosis was evaluated by terminal deoxynucleotidyl transferase (TdT)‐mediated deoxyuridine triphosphate biotin nick end labelling (TUNEL) assay, using Apoptag Kit (CHEMICON International, Temecula, CA, USA) according to the manufacturer's instructions.…”

“…Sj€ ogren syndrome, SS), therapeutic modalities (drugs, chemo-and radiotherapy) and contaminants' intake are able to induce salivary gland dysfunction (Guggenheimer and Moore, 2003;Atkinson et al, 2005;Dodds et al, 2005;Prestifilippo et al, 2011). Moreover, it was previously reported that periodontitis produced hyposialia, worsening the evolution of periodontal disease (Amer et al, 2011;Prestifilippo et al, 2012). It is worth mentioning that recent evidence supports the hypothesis that periodontitis is a risk factor for several pathologies, including atherosclerotic cardiovascular disease (Kholy et al, 2015), Alzheimer's disease and type 2 diabetes (Shaik et al, 2014).…”