Histaminergic Control of Mucosal Repair in the Small Intestine

Abstract

ICHI OGATA, SEIJI TSUNADA, TAKASHI OHYAMA, AKIFUMI OOTANI, KAZUYO OKAMOTO AND TOSHIIE SAKATA. Histaminergic control of mucosal repair in the small intestine. Obes Res. 1995;3(Suppl5):795S-799S. The aim of the present paper was to summarize histamine-mediated repair of rat intestinal mucosa. To evaluate intestinal repair, we examined lipid transport (an index of intestinal mucosal function) after 15 minutes occlusion of the superior mesenteric artery. Rats were pretreated with a-fluoromethylhistidine (a suicide inhibitor of histidine decarboxylase, a synthesizing enzyme of histamine), HI-receptor antagonist (chlorpheniramine maleate), H2-antagonist (cimetidine), or H3-antagonist (thioperamide) before ischemia-reperfusion (VR). Lipid transport to rat mesenteric lymph decreased significantly 24 hours after YR in all groups tested compared to sham-treated rats. Lipid transport was restored 48 hours after VR in the vehicle-pretreated control group. Lipid transport was not restored to the control level 48 hours after VR in rats pretreated with HI-antagonist and a suicide inhibitor of histidine decarboxylase. In contrast, intestinal function was restored to the control level 48 hours after UR in rats pretreated with H2-and H3-antagonists. These results support our previous findings that newly formed histamine after I/R plays an important role in mucosal recovery through HI-receptors. FUJIMOTO, KAZUMA, YUDAI GOTOH, SHIN-