Histidine-rich glycoprotein (HRGP): Pleiotropic and paradoxical effects on macrophage, tumor microenvironment, angiogenesis, and other physiological and pathological processes

The Association between Histidine-Rich Glycoprotein rs10770 Genotype and Recurrent Miscarriage in Iranian Women

“…In this mutation, one nucleotide (T) is replaced by C, which changes isoleucine to threonine at amino acid position 180 in the protein. This mutation has an important role in antiangiogenesis [ 11 ] and angiogenesis [ 32 ]. HRG is not considered a factor for angiogenesis; however, it can affect angiogenesis in different ways [ 11 ].…”

“…This mutation has an important role in antiangiogenesis [ 11 ] and angiogenesis [ 32 ]. HRG is not considered a factor for angiogenesis; however, it can affect angiogenesis in different ways [ 11 ].…”

“…HRG protein consists of three main sections: (1) two N-terminal regions (N1 and N2), (2) the histidine-rich region (HRR) surrounded by two proline-rich regions (PRR1 and PRR2), and (3) the C-terminal domain [ 10 ]. This protein also has four intradomain disulfide bonds, two interdomain disulfide bonds, and six N-glycosylated regions [ 11 ]. HRG is a protein that acts as an adapter and can bind to various ligands including heparin [ 12 ], tropomyosin [ 13 ], plasminogen [ 9 ], Zn2+ [ 14 ], thrombospondin (TSP) [ 15 ], heme [ 16 ], fibrinogen [ 17 ], complement components [ 18 ], phospholipids [ 19 ], vasculostatin [ 20 ], and immunoglobulin G [ 21 ].…”

Chick chorioallantoic membrane (CAM) assay for the evaluation of the antitumor and antimetastatic activity of platinum-based drugs in association with the impact on the amino acid metabolism

“…On the other hand, the observation of less extensive, but similar trends of the impact to the amino acid profile between in vitro and in vivo experiments upon PtNPs treatments, suggests lower negative impact of the PtNPs to non-cancer tissues, probably arising from the EPR effect [ 25 , 48 , 49 ]. However, an interesting observation was the significant decrease of His, consistent upon all treatments, which could indicate a possible effect of CDDP and PtNPs on the angiogenetic regulation mediated through histidine-rich glycoprotein [ 64 ].…”

Insight into the antibacterial mechanism of Cu-enriched sol–gel coatings employing proteomics

“…37 Similarly, the HRG can modulate M1 macrophage polarisation and regulate angiogenesis, fibrinolysis, and coagulation processes. 38 Antibacterial properties of this protein have been also reported against Gram-positive and Gram-negative strains by inducing pathogen lysis. 39 Besides these two proteins, increased adsorption of HEP2 and pro-coagulation factors FA9 and FA10 40 and PLMN (known for its essential role in fibrinolysis 41 ) was observed on the 3Cu coating.…”