Histochemical effects of fluacizine on flavin dehydrogenase activity in the rat brain

Abstract— Pentobarbitone sodium anaesthesia was found to produce an increase in protein content in some regions of the rat brain, i.e. posterior cortex, caudate nucleus, and a decrease in protein content in the ventral cortex. Acetylcholinesterase expressed in terms of wet weight was found to increase in the cerebellum, medulla, and to decrease in the medial cortex, hippocampus, thalamus and caudate nucleus. The changes in activity were not explicable in terms of a direct effect of the anaesthetic on the enzyme. A decrease in protein content of rat brain was observed in the frontal cortex, ventral cortex, hippocampus and caudate nucleus after electrical shocks. Following shock avoidance conditioning procedure (shuttle‐box), decreases in protein content were observed in the medial cortex, posterior cortex, cerebellum and ventral cortex; in the thalamus an increase in protein content was observed. Changes in AChE activity were observed following footshock in the frontal cortex and medulla where there was an increase in activity and in the caudate nucleus, hypothalamus, thalamus, and olfactory tubercle where there was a decrease in activity. Following shock avoidance conditioning the activity of the AChE increased in posterior cortex, hippocampus, thalamus and hypothalamus and the activity of the enzyme decreased in the ventral cortex.

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Hemodialysis for Methanol Intoxication

Tobin

Lianos

1979

Journal of Dialysis

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A patient with toxic levels of methanol was hemodialyzed while receiving an ethanol infusion. It was demonstrated that during the dialysis significant quantities of both ethanol (17.70 gms) and methanol (26.69 gms) were extracted. Also, it was shown that the ethanol did not competetively inhibit the extraction of the methanol. Since ethanol is removed in significant quantities during dialysis, one should increase its infusion rate during hemodialysis and decrease the rate when the patient is not being dialyzed. This would achieve adequate and constant blood levels of ethanol and would satisfactorily inhibit the metabolism of methanol by the liver.

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Histochemical effects of fluacizine on flavin dehydrogenase activity in the rat brain

Cited by 3 publications

References 6 publications

Effect of nembutal anesthesia, electric shock, and shock avoidance conditioning on acetylcholinesterase activity and protein content in various regions of the rat brain

Effect of nembutal anesthesia, electric shock, and shock avoidance conditioning on acetylcholinesterase activity and protein content in various regions of the rat brain

The Effects of Pentobarbitone‐sodium Anaesthesia, Shock Avoidance Conditioning and Electrical Shock on Acetylcholinesterase Activity and Protein Content in Regions of the Rat Brain

Hemodialysis for Methanol Intoxication

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