Histochemical Study of the Changes in Endometrial Fibrinolytic Activity During Treatment of Menometrorrhagia with Antifibrinolytics

Koutsky, J; Jirásek, J

doi:10.1159/000302089

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…In some women with menorrhagia and a normal-sized uterus the concentration of plasminogen activators in the endometrium was significantly increased as compared with the concentration in women with normal menstrual blood loss (29). The decrease in the menstrual blood loss during therapy with synthetic fibrinolytic inhibitor also supports the importance of fibrinolysis in relation to the menstrual blood loss (18,27).…”

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confidence: 78%

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Fibrinogen‐Fibrin Degradation Products in Menstrual Blood from Women with Normal and Excessive Menstrual Blood Losses

Hahn

Rybo

1975

Acta Obstet Gynecol Scand

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Fibrinogen-fibrin degradation products, FDP, in menstrual blood during the first three days of menstrual blood during the first three days of menstruation have been investigated. Two groups of women were studied, those with normal menstrual blood loss (15 women, mean loss 30 ml, range 8-60 ml) and those with menorrhagia (14 women, mean loss 222 ml, range 107-729 ml). The following results were obtained: 1). The FDP concentrations decreased during menstruation in both groups. 2). The FDP concentrations in the two were compared for each day of the menstrual period. No differences were found between the two groups. A possible explanation of the results is given: there is a higher rate of coagulation and fibrinolysis in the endometrium of women with menorrhagia compared with women with normal blood losses. The hypothesis is supported by results of studies in which tranexamic is supported by results of studies in which tranexamic acid, an inhibitor of fibrinolysis, was given to reduce the menstrual blood loss. 3). The FDP excretion patterns differed from women to women. There were no consistent differences between the menorrhagic and the control group.

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confidence: 78%

“…The amount of menstrual blood loss is influenced, among other factors, by the efficiency of the hemostatic mechanism. The human endometrium contains both thromboplastic and fibrinolytic components (3,4,8,12,18,29,31). Most authors (4,12,22,30,35) are of the opinion that clotting of the blood entering the uterine cavity is followed by fibrinolysis.…”

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confidence: 99%

Fibrinogen‐Fibrin Degradation Products in Menstrual Blood from Women with Normal and Excessive Menstrual Blood Losses

Hahn

Rybo

1975

Acta Obstet Gynecol Scand

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“…Bei uterinen Hyperfibrinolysen haben sich Antifibrinolytika vom Typ des AMCHA (Aminomethylzyklohexankarbonsäure) bewährt [3][4][5]8].…”

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Beitrag zur Frage der Genitalblutungen bei hämorrhagischen Diathesen

Felder¹

1969

Gynäkol Geburtshilfliche Rundsch

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Plasminogenaktivator und andere trypsin�hnliche Proteasen im Geb�rmuttergewebe und ihre Teilnahme an den Gewebsblutungen

1975

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In the myometrium and endometrium a content of plasminogen activator and non-specific trypsin-like proteases was determined. It was ascertained that there was a higher level of plasminogen activator in the endometrium during the menstruation in the contrary to the first and second phase of the menstrual cycle and that both plasminogen activator and non-specific trypsin-like proteases were relative higher in Corpusmyometrium than those Cervixmyometrium. The proteases present in the fractions of myometriumeluate were able to split casein and partially fibrin, too. These activities were not inhibited by epsilon aminocaproic acid and aprotinin. The importance of these findings for gynaecological bleeding was suggested.

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Histochemical Study of the Changes in Endometrial Fibrinolytic Activity During Treatment of Menometrorrhagia with Antifibrinolytics

Cited by 3 publications

References 9 publications

Fibrinogen‐Fibrin Degradation Products in Menstrual Blood from Women with Normal and Excessive Menstrual Blood Losses

Fibrinogen‐Fibrin Degradation Products in Menstrual Blood from Women with Normal and Excessive Menstrual Blood Losses

Beitrag zur Frage der Genitalblutungen bei hämorrhagischen Diathesen

Plasminogenaktivator und andere trypsin�hnliche Proteasen im Geb�rmuttergewebe und ihre Teilnahme an den Gewebsblutungen

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