Histochemistry XIX. Localization of Alkaline Phosphatase in Normal and Pathological Human Skin.

Fisher, I; Glick, David

doi:10.3181/00379727-66-15967

Cited by 46 publications

(6 citation statements)

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“…Hislochemical findings Repeated previous examinations of skin from subjects at room tem perature or under general anaesthesia have enabled us to confirm previous observations [5,6,7,8], i. c. th at the phosphomonoesterases are found in the acinar cells of the secretory coil and in no other part of the eccrine apparatus. The sole exception is the occasional presence of alkaline phosphatase as a luminal layer in the ampulla, as mentioned above; even here it has been seen only in specimens removed under general anesthesia, when the dilated state of the ampulla suggests that active sweating is occurring [1].…”

Section: Phosphomonoesterases In Sweatsupporting

confidence: 75%

Phosphomonoesterases in Eccrine Sweat and Their Localization after Prolonged Sweating

Loewenthal¹,

Hins²

1963

Dermatology

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Section: Phosphomonoesterases In Sweatsupporting

confidence: 75%

Phosphomonoesterases in Eccrine Sweat and Their Localization after Prolonged Sweating

Loewenthal¹,

Hins²

1963

Dermatology

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“…In three other cases lobules were more 58 CANCER January 1954 VOl. 7 frequent, an average of from one to two being present in each section, while in only one case could they be considered as being numerous. This latter case was in a 65-year-old woman with advanced breast cancer who was approximately seventeen years postmenopausal and in whom the breast tissue was composed of relat vely thin bands of parenchyma rather widely separated by fat.…”

Section: Resultsmentioning

confidence: 99%

Histological and histochemical alterations in the normal breast tissues of patients with advanced breast cancer being treated with estrogenic hormones

Huseby

Thomas

1954

Cancer

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“…During the healing of skin wounds there is some increase in alkaline phosphatase activity in the stratum granulosum, which returns to normal when keratinization is re-established. T h e phosphatase in both normal and regenerating epithelium appears to be localized in the keratohyalin granules, an association that has been observed in man (Fisher & Glick, 1947;Pirila & Eranko, 1950), guinea-pig (Bourne, 1944), rat (Washburn, 1955) and mouse (Hardy, 1952), although Kopf (1957) has claimed that in human skin false positive results are sometimes given by keratohyalin granules. Its presence in this site suggests a relationship between fibrous protein synthesis and alkaline phosphatase activity.…”

Section: Skin (I) Epidermismentioning

confidence: 86%

The Cytology of Wound Healing of Body Surfaces in Mammals

Johnson¹,

McMinn²

1960

Biological Reviews

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SUMMARY The cytological aspects of the repair of wounds with loss of substance in the skin, cornea and a number of mucous, serous and synovial membranes in mammals (laboratory animals and man) have been reviewed. It is emphasized that, as in the last century, the majority of studies of wound healing continue to be carried out on skin, and the need for examining repair processes in other organs is stressed. While most of the evidence indicates that epithelium regenerates from old epithelium at the wound margin, the surfaces of serous and synovial membranes are probably repaired by metaplasia of underlying connective tissue cells, assisted by the implantation of islands of surface cells that have desquamated from adjacent surfaces. The epithelia of the gall‐bladder and urinary bladder (in the cat) display abundant evidence of mitosis in migrating cells. Mitosis in spreading cells has also been observed in ileal and rectal epithelium. While migration remains a primary factor in epithelial repair, the role of mitosis has possibly been underestimated in the past. The origin of the connective tissue cells of granulation tissue remains an enigma. There is evidence suggesting that the fibrocytes of the dermis do not proliferate, and that new connective tissue cells are haematogenous in origin. The endothelial (vascular and lymphatic) elements of granulation tissue originate by budding from pre‐existing vessels. There is doubt whether mitosis occurs in such endothelial cells. In the repair of mucous membranes in the alimentary tract, new gland formation is observed regularly in the stomach, duodenum and ileum in all the species that have been investigated, including man. The colon and rectum appear to exhibit less regenerative capacity than higher levels of the alimentary tract, for there is no consistent evidence for new gland formation in these viscera. No universally applicable explanation is yet forthcoming for the accumulation of glycogen that can be detected histochemically in many, but not all, of the regenerating epithelia that have so far been studied. Among the urgent items on which cytological research might be prosecuted in the future are: the possible role of metaplasia of connective tissue cells in the production of new epithelium, mitosis in migrating epithelium, the factors regulating the initiation and cessation of mitosis, the problem of the origin of new connective tissue cells, and the causes of contraction. Compared with the number of purely morphological studies, histochemistry and autoradiography have not often been wedded to the problems of repair, while the whole field of wound healing at the cellular level awaits study with the electron microscope.

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Histochemistry XIX. Localization of Alkaline Phosphatase in Normal and Pathological Human Skin.

Cited by 46 publications

References 0 publications

Phosphomonoesterases in Eccrine Sweat and Their Localization after Prolonged Sweating

Phosphomonoesterases in Eccrine Sweat and Their Localization after Prolonged Sweating

Histological and histochemical alterations in the normal breast tissues of patients with advanced breast cancer being treated with estrogenic hormones

The Cytology of Wound Healing of Body Surfaces in Mammals

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