Histocompatibility antigens in Egyptians with cutaneous leishmaniasis: a preliminary study

Elmogy, Mohamed Hussein; Abdel‐Hamid, Ibrahim A.; Abdel-Razic, Moheb M.; Rizk, Rizk A; Romia, S. A.

doi:10.1016/0923-1811(93)90075-z

Cited by 9 publications

(4 citation statements)

References 4 publications

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“…In Venezuela, the HLA-A11, -B5, -B7, -Bw2 andDQw3 antigens were found to be associated with an increased susceptibility to cutaneous leishmaniasis [48]. In Egypt, association with the HLA-A11, -B5 and -B7 antigens was suggested [49,50]. Petzl-Erler et al (1991), in Brazil, showed that the HLA-DQw3 antigen was associated with greater susceptibility, and HLA-DR2, with greater protection [51].…”

Section: Parasitic Infectionsmentioning

confidence: 99%

Immunogenetics and infectious diseases: special reference to the mayor histocompatibility complex

Alves¹,

Souza²,

Meyer³

et al. 2006

Braz J Infect Dis

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Many studies have tried to identify genetic markers for infectious diseases, some of them have focused on human leukocyte antigens (HLA). The products of HLA genes interact with surfacespecific receptors of T lymphocytes, resulting in activation of the host's immune response. Association of bacterial, viral, parasitic and fungal infections with the host's HLA has been widely investigated. The type and strength of this association differs among distinct populations, as well as among racial and/or ethnic groups. The new molecular methods for the identification of the HLA alleles, and the resulting new nomenclature, have contributed to a better understanding of this system. Unfortunately, this information has not been adequately transmitted to clinicians, which hampers the understanding of the association between the HLA system and diseases. We revised relevant studies on the association of HLA genes with infectious diseases, demonstrating their importance in the pathogenic mechanisms, through increased susceptibility or protection against infections and their complications.

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Section: Parasitic Infectionsmentioning

confidence: 99%

Immunogenetics and infectious diseases: special reference to the mayor histocompatibility complex

Alves¹,

Souza²,

Meyer³

et al. 2006

Braz J Infect Dis

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“…Here we will focus on genetic susceptibility to ACL, beginning with the demonstration of familial aggregation of ACL disease in Corte de Pedra that led to analysis of specific candidate genes arising both from our knowledge of immune responses to human L. braziliensis infection, and through consideration of wound healing genes that was inspired initially by studies in mice (Sakthianandeswaren et al 2005, 2009, 2010). These data are further discussed in relation to studies of genetic susceptibility to CL in other geographic regions, as summarised along with all published (Barbier et al 1987, Lara et al 1991, Petzl-Erler et al 1991, El-Mogy et al 1993, Cabrera et al 1995, Karplus et al 2002, Olivo-Diaz et al 2004, Castellucci et al 2006, 2010, 2011, 2012, Kamali-Sarvestani et al 2006, Matos et al 2007, Salhi et al 2008, Ajdary et al 2010, 2011, Ramasawmy et al. 2010, Samaranayake et al 2010, Oliveira et al 2011, Fernández-Figueroa et al 2012, Covas et al 2013) data on susceptibility to CL in Table I.…”

mentioning

confidence: 99%

Host genetic factors in American cutaneous leishmaniasis: a critical appraisal of studies conducted in an endemic area of Brazil

Castellucci

Almeida

Jamieson

et al. 2014

Mem. Inst. Oswaldo Cruz

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American cutaneous leishmaniasis (ACL) is a vector-transmitted infectious disease with an estimated 1.5 million new cases per year. In Brazil, ACL represents a significant public health problem, with approximately 30,000 new reported cases annually, representing an incidence of 18.5 cases per 100,000 inhabitants. Corte de Pedra is in a region endemic for ACL in the state of Bahia (BA), northeastern Brazil, with 500-1,300 patients treated annually. Over the last decade, population and family-based candidate gene studies were conducted in Corte de Pedra, founded on previous knowledge from studies on mice and humans. Notwithstanding limitations related to sample size and power, these studies contribute important genetic biomarkers that identify novel pathways of disease pathogenesis and possible new therapeutic targets. The present paper is a narrative review about ACL immunogenetics in BA, highlighting in particular the interacting roles of the wound healing gene FLI1 with interleukin-6 and genes SMAD2 and SMAD3 of the transforming growth factor beta signalling pathway. This research highlights the need for well-powered genetic and functional studies on Leishmania braziliensis infection as essential to define and validate the role of host genes in determining resistance/susceptibility regarding this disease.

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“…64 In the Egyptian population, a significant association was found between Class I HLA-A11, -B5 and -B7 antigens and DCL. 60,65 Evaluating Classes I and II of HLA antigens, Lara et al suggested that HLA-Bw22 and -DQw3 antigens were positively associated with LCL in the Venezuelan population. 66 A study in Mexican mestizos showed that HLA-DQ3 antigen and HLA-DRB1*0407, -DQA1*3011, -DPA1*0401 and -DPB1* 0101 alleles were associated with susceptibility for LCL, whereas the HLA-DR2 group (-DRB1*1500, -DRB1*1600) and HLA-DPB1*0401 allele was associated with protection.…”

Section: Cutaneous Leishmaniasismentioning

confidence: 99%

Antígenos de histocompatibilidade humanos e dermatologia: da pesquisa para a prática clínica

Alves

Vieira

Meyer

et al. 2006

An. Bras. Dermatol.

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Abstract:The participation of the human histocompatibility system (HLA: human leukocyte antigens) in the pathogenesis of autoimmune diseases is well known. Situated on the short arm of chromosome 6, the HLA system is very polymorphic and has the capacity to confer susceptibility or resistance to different diseases. In Dermatology, this system has an important participation in the pathogenesis and natural course of various diseases. The strength and type of association differ with conditions and sometimes with the ethnic-racial group studied. The discovery of molecular methods to typify HLA alleles and recent updates in its nomenclature has contributed to a better understanding of this system. Unfortunately, this information has not been adequately transmitted in the literature, hindering identification of the association of the HLA with skin diseases. In this review, some aspects of the HLA system are discussed, such as methods of detection, nomenclature and association with vitiligo, pemphigus, psoriasis, lupus erythematosus, scabies, cutaneous leishmaniasis, leprosy, paracoccidiodomycosis and atopic dermatitis.

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Histocompatibility antigens in Egyptians with cutaneous leishmaniasis: a preliminary study

Cited by 9 publications

References 4 publications

Immunogenetics and infectious diseases: special reference to the mayor histocompatibility complex

Immunogenetics and infectious diseases: special reference to the mayor histocompatibility complex

Host genetic factors in American cutaneous leishmaniasis: a critical appraisal of studies conducted in an endemic area of Brazil

Antígenos de histocompatibilidade humanos e dermatologia: da pesquisa para a prática clínica

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