Histocompatibility Determinants in Multiple Sclerosis, With Special Reference to Clinical Course

Jersild, Casper; Hansen, Georg Nørgaard; Svejgaard, A.; T, Fog; Thomsen, Mögens; Dupont, Bo

doi:10.1016/s0140-6736(73)90970-7

Cited by 430 publications

(183 citation statements)

References 10 publications

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“…Therefore it is important to determine whether Dw4 positive patients have more severe disease. In a similar study Jersild et a1 found that multiple sclerosis patients with HLA-Dw2 (LD7a) had more active disease (17). A retrospective analysis of the clinical data showed that Dw4 positive patients appeared to require more aggressive drug therapy and had slightly more severe disease on clinical assessment.…”

Section: Discussionmentioning

confidence: 94%

Increased Frequency of HLA‐Cw3 and HLA‐Dw4 in Rheumatoid Arthritis

McMichael

Sasazuki

McDevitt

et al. 1977

Arthritis & Rheumatism

144

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Section: Discussionmentioning

confidence: 94%

Increased Frequency of HLA‐Cw3 and HLA‐Dw4 in Rheumatoid Arthritis

McMichael

Sasazuki

McDevitt

et al. 1977

Arthritis & Rheumatism

144

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“…As described above, the first genetic associations identified in MS were found for HLA class I alleles using serologic typing of HLA antigens on leukocytes Jersild et al, 1972Jersild et al, , 1973Naito et al, 1972). When HLA class II alleles were also associated with MS susceptibility, it was proposed that the class I associations were accounted for by linkage disequilibrium with the class II loci (Winchester et al, 1975;Compston et al, 1976;Terasaki et al, 1976).…”

Section: The Mhc and Ms Susceptibilitymentioning

confidence: 99%

“…These early studies found that certain cell surface proteins (antigens), that are present on the membranes of peripheral blood mononuclear cells, were overrepresented in MS patients compared to unaffected controls. The first such antigens to be reported were HLA-A3 Naito et al, 1972), followed by HLA-B7 and then HLA-DRw2 (Jersild et al, 1972(Jersild et al, , 1973Winchester et al, 1975;Compston et al, 1976;Terasaki et al, 1976). As it turned out, these HLA associations were not independent of each other but rather reflected a common shared haplotype due to the fact that the chromosomal region coding for these proteins was in Assumes lifetime population prevalence of 0.2% (Ebers et al, 2000;Dyment et al, 2004a).…”

Section: Human Leukocyte Antigensmentioning

confidence: 99%

Multiple sclerosis genetics

Cree

2014

Handbook of Clinical Neurology

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“…Perivascular T-and B cell infiltrates have also been observed in both intracortical and sub-pial lesions in progressive multiple sclerosis cases 55 , particularly in subjects in whom progressive disease with signs of activate inflammation was present at death. 76,77 . In fact, a recent study suggested that HLA-DRB1*15…”

Section: Role Of Parenchymal and Perivascular Lymphocytesmentioning

confidence: 99%

Exploring the origins of grey matter damage in multiple sclerosis

et al. 2015

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Multiple sclerosis is characterized at the gross pathological level by the presence of widespread focal demyelinating lesions of the myelin-rich white matter. However, it is becoming clear that grey matter is not spared, even during the earliest phases of the disease. Furthermore, grey matter damage may have an important role both in physical and cognitive disability. Grey matter pathology involves both inflammatory and neurodegenerative mechanisms, but the relationship between the two is unclear. Histological, immunological and neuroimaging studies have provided new insight in this rapidly expanding field, and form the basis of the most recent hypotheses on the pathogenesis of grey matter damage. DOI: https://doi.org/10.1038/nrn3900Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-111099 Accepted Version Originally published at: Calabrese, Massimiliano; Magliozzi, Roberta; Ciccarelli, Olga; Geurts, Jeroen J G; Reynolds, Richard; Martin, Roland (2015). Exploring the origins of grey matter damage in multiple sclerosis. Nature Reviews Neuroscience, 16 (3) AbstractMultiple sclerosis is characterised at the gross pathological level by the presence of widespread focal demyelinating lesions of the myelin-rich white matter. However, in recent years it has become clear that grey matter is not spared, even during the earliest phases of the disease. Furthermore, grey matter damage has been suggested to have an important role both in physical and cognitive disability. Grey matter pathology involves both inflammatory and neurodegenerative mechanisms, but the relationship between the two is unclear. This review will summarize and highlight important histological, immunological, and neuroimaging results from this rapidly expanding field and will address the most recent hypotheses on the pathogenesis of grey matter damage.

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Histocompatibility Determinants in Multiple Sclerosis, With Special Reference to Clinical Course

Cited by 430 publications

References 10 publications

Increased Frequency of HLA‐Cw3 and HLA‐Dw4 in Rheumatoid Arthritis

Increased Frequency of HLA‐Cw3 and HLA‐Dw4 in Rheumatoid Arthritis

Multiple sclerosis genetics

Exploring the origins of grey matter damage in multiple sclerosis

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