Histogenesis of solid pseudopapillary tumor of the pancreas: the case for the centroacinar cell of origin

Kallichanda, Nathash; Tsai, Steve; Stabile, Bruce E.; Buslon, Virgil; Delgado, Doris L.; French, Samuel W.

doi:10.1016/j.yexmp.2006.05.005

Cited by 37 publications

(29 citation statements)

References 11 publications

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“…The immunohistochemical results are important for the diagnosis of SPT. The cells are positive for vimentin, neuron-specific nolase (NSE), α-1-antitrypsin, α-1-antichymotrypsin as well as some newly identified markers such as CD10 and cyclin D1 [5] . And cytokeratin, S100, synaptophysin, and chromogranin are generally negative.…”

Section: Discussionmentioning

confidence: 99%

Solid pseudopapillary tumor of the pancreas: a case report

Zheng

Zhang

Han

et al. 2007

Chin. J. Clin. Oncol.

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Solid pseudopapillary tumors (SPT) of the pancreas are considered to be a rare low-grade malignancy that mainly appears in young women. It accounts for less than 1% of all pancreatic neoplasms and is pathologically distinctive from other types of pancreatic cancers. Curative resection is the optimal choice for SPT and the 5-year survival rate of SPT is about 95%. Here we report a case of a young girl who presented with this rare pancreatic tumor.This case involved a 21-year-old girl with a 3-month history of a slowly growing palpable mass in the right upper abdomen.There were no accompaning symptoms, except for a 5-kilogram weight loss since the onset of the disease. Her past medical history as well as that of her family was unremarkable. Physical examination showed a distinct mass in the right upper quadrant which showed no tenderness.The routine test of blood and the serum tumor markers, such as CEA and CA19-9, were within normal levels.An abdomenal CT scan revealed a well-encapsulated, 6.9×9.3 cm 2 mass in the right retro-peritoneal area with a cystic lesion inside. The pancreatic head, duodenum and the right kidney were pushed aside, but there was no sign of invasion into the surrounding organs and the important vessels (Fig.1).The patient underwent a laparotomy after sufficient preparation. Intraoperatively, a large, well-encapsulated mass was detected in the posterior surface of the pancreatic head with no invasion of the surrounding area. A tumor resection was performed (Fig.2), and her recovery was routine so she was discharged 19 days after surgery.Post-operative pathologic examination revealed a 9×9×7 cm 3 nodi-formed mass mixed with zones of hemorrhage.The cells were small and uniform with nuclei that were ovoid with nuclear grooves and with inconspicuous nucleoli (Fig.3). Immunohistochemical results showed that the cells were negative for cytokeratin, S100, synaptophysin, and chromogranin stains and positive for vimentin, CD10, neuron-specific enolase (NSE) and CD56. The immunohistochemical results supported the diagnosis of a solid pseudopapillary tumor of the pancreas. DiscussionSolid pseudopapillary tumors (SPT) of the pancreas, which were first reported by Frantz in 1959 [1] , were named and reclassified by

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Section: Discussionmentioning

confidence: 99%

Solid pseudopapillary tumor of the pancreas: a case report

Zheng

Zhang

Han

et al. 2007

Chin. J. Clin. Oncol.

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“…The tumor cells stain positive for alpha-antitrypsin (alpha-AT), CD10, cyclin D1, vimentin, and NSE. In a recent study centroacinar cells were found to express the same immunohistochemical pattern, suggesting a direct relationship on to histogenesis [9].…”

Section: Discussionmentioning

confidence: 81%

Solid pseudopapillary tumor of the pancreas in children: report of a case and review of the literature

et al. 2010

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Solid pseudopapillary tumor (SPT) of the pancreas is an infrequent neoplasm of low malignant potential, first described by Frantz in 1933 and representing less than 3% of all exocrine tumors. SPT is rare in children, accounting for 6% of all cases and shows different clinical features compared with adults. Here, a pediatric case is reported and a review of the Literature is provided. A 15-year-old girl with a 12 × 14 × 10 cm solid mass growing from the tail and the body of the pancreas, involving spleen, left adrenal gland and kidney, stomach and some bowel loops, was referred for surgical treatment. A distal pancreasectomy with splenectomy was performed. Histopathological examination revealed that the tumor was a 14-cm well-circumscribed solid mass, with pseudopapillary cell architecture, showing strong cellular immunoreactivity for alpha-1 antitrypsin, vimentin, neurone-specific enolase, progesterone receptors and in part to CD10 and CAM 5.2, but not to sinaptofisin and chromogranin. A 24-month post-surgical follow-up after successful surgical resection showed no evidence of recurrent disease. SPT shows different clinical features in childhood. High survival rates can be achieved in most cases, warranting aggressive treatments even in metastatic disease.

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“…Solid pseudopapillary tumors of the pancreas affect primarily young women, suggesting that hormonal factors contribute to the tumor growth [4,5,8]. In the current study, symptoms were reported at a woman of 28 years of age, an age at which female hormones and their receptors such as progesterone, estrogen are very active and might play a role in the development of solid pseudopapillary tumor of the pancreas [9,10].…”

Section: Discussionmentioning

confidence: 92%

“…It is almost exclusively seen in females and occurs in the second or third decades of life [3], suggesting that this tumor is associated with some female hormones and their receptors such as estrogen, progesterone and opioids [4,5]. Several lines of evidence support the role of G protein-coupled receptor cholecystokinin 2 and gastrin (CCK-2R/gastrin-R) in pancreatic cancer development [6,7].…”

Section: Introductionmentioning

confidence: 99%

CCK-2/Gastrin-R Immunodistribution in a Solid Pseudopapillary Pancreatic Tumor: A Case Report of a 28-Years-Old North African Woman

Harir¹

2016

Glob J Medical Clin Case Rep

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The presence of a large bulky pancreatic tumour in a young female should raise suspicions of the diagnosis of solid-pseduopapillary tumour of the pancreas.Solid pseudopapillary neoplasms of the pancreas are uncommon, accounting for only 1-2% of all pancreatic neoplasms. These tumors are being detected at an increased rate, probably due to the increased awareness and the liberal use of imaging.We report a case of a 28-year-old North African woman with no prior medical or surgical history diagnosed with solid pseudopapillary pancreatic tumor. Our immunohistochemical study demonstrated that the tumor cells were positive for CCK-2/gastrin receptors and that were highly expressed within the cytoplasmic area of the cells. Hence we attempted to raise a hypothesis and to establish a link between some female hormones which represents powerful regulators of the expression of CCK and their possible impact on the development of solid pseudopapillary pancreatic tumours in young women.were unremarkable. Laboratory data including hematology, blood chemistry including amylase and lipase, as well as tumor markers were within the reference limits (CEA = 0.692 ng/ml, CA 125 = 12.27 Ul/ml, and CA 19-9 = 22.59 Ul/ml).Ultrasound imaging (Figure 1) showed a solid heterogeneous mass at the level of left quadrant measuring 124 mm.CT scan of the abdomen ( Figure 2) revealed a voluminous hypoattenuating mass in the tail and the body of the pancreas, measuring 127mm x 87mm with multiple intratumoral vessels.After a surgical biopsy was performed; histological examination demonstrated a solid pattern with non infiltrant pseudopapillary cores; the tumor was found to be confined to the pancreas ( Figure 3). Our immunohistochemical analysis revealed that the tumor cells IntroductionSolid Pseudopapillary Tumor (SPT) of the pancreas is a very rare entity with a reported incidence of 0.13% to 2.7% of all pancreatic tumors [1], this tumor was once described in many other terms, such as Frantz's tumor, solid and cystic tumor, papillary cystic neoplasm, and solid and papillary epithelial neoplasm [2].It is almost exclusively seen in females and occurs in the second or third decades of life [3], suggesting that this tumor is associated with some female hormones and their receptors such as estrogen, progesterone and opioids [4,5]. Several lines of evidence support the role of G protein-coupled receptor cholecystokinin 2 and gastrin (CCK-2R/gastrin-R) in pancreatic cancer development [6,7].In order to study immunohistochemical features of G protein coupled CCK2/gatrin receptors in this kind of rare tumors, we herein present a case of solid pseudopapillary pancreatic tumor associated with a positive CCK-2/gastrin-R reactivity. Case ReportA 28-year-old North African woman with no prior medical or surgical history presented with complaints of epigastric and right upper quadrant (RUQ) pain and decreased appetite during one month. Her pulse rate was 72 min-1 and her blood pressure was 110/60 mmHg. There was no precipitating or aggravating factor and...

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Histogenesis of solid pseudopapillary tumor of the pancreas: the case for the centroacinar cell of origin

Cited by 37 publications

References 11 publications

Solid pseudopapillary tumor of the pancreas: a case report

Solid pseudopapillary tumor of the pancreas: a case report

Solid pseudopapillary tumor of the pancreas in children: report of a case and review of the literature

CCK-2/Gastrin-R Immunodistribution in a Solid Pseudopapillary Pancreatic Tumor: A Case Report of a 28-Years-Old North African Woman

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