Histologic and histomorphometric assessment of sinus‐floor augmentation with beta‐tricalcium phosphate alone or in combination with pure‐platelet‐rich plasma or platelet‐rich fibrin: A randomized clinical trial

Kılıç, Songül Cömert; Güngörmüş, Metin; Parlak, Seçil Nazife

doi:10.1111/cid.12522

Cited by 62 publications

(35 citation statements)

References 33 publications

(60 reference statements)

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“…Since the sample studied was taken from the graft and not native bone, these results clearly suggest bone neofromation in the grafted material, and presumably the ingrowth of osteoprogenitor cells come from the periostium and the residual bone to the graft. On the other hand, the results from the quantitative study are in good agreement with previous reports [16,17] but the heterogeity of the methods used difficult to compare the results.…”

Section: Resultssupporting

confidence: 90%

Maxillary Ridge Vertical Augmentation Based on a Mixture of Xenogenic and Allogenic Bone Supported by Resorbable Membrane: One Case Report

Gonzalez-Menendez¹,

Gonzalez-Tuñon²,

Ordóñez³

et al. 2019

JDMS

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One 60 years-old patient was scheduled for left posterior maxillary ridge augmentation due to failure of standard implants, followed by successful maxillary dental implants. We used an unproved technique consisting in a mixture of 50% allogenic and 50% xenogenic bone supported by reabsorbable membrane. No complications were found at the different stages of the treatment, and at the ending the patient showed a good level of satisfactory outcomes. Radiological evaluation demonstrated ridge augmentation able to support implant, and within the graft islands of connective and bone-like tissue was found. Within these tissues osteoclasts and osteoblast putative cells were found. Results demonstrate that the used method in addition to support implants has osteogenic and bone remodeling activity.

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Section: Resultssupporting

confidence: 90%

Maxillary Ridge Vertical Augmentation Based on a Mixture of Xenogenic and Allogenic Bone Supported by Resorbable Membrane: One Case Report

Gonzalez-Menendez¹,

Gonzalez-Tuñon²,

Ordóñez³

et al. 2019

JDMS

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“…There were 18 maxillary sinus elevations, with no reported complications and 37 implant placements in a delayed protocol (Table 2). Among the 12 studies, two were retrospective studies [69,70], one was a CCT [71], and nine were RCTs [41,42,45,[72][73][74][75][76][77], of which three had a split mouth design [41,42,74]. Follow-up ranged from one week to two years.…”

Section: Sole Use Of Platelet Concentrates In Sinus Floor Augmentationmentioning

confidence: 99%

Platelet-Rich Plasma in Maxillary Sinus Augmentation: Systematic Review

et al. 2020

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Background: Sinus augmentation can be performed with or without grafting biomaterials, and to date, there is no quality evidence regarding the augmentation of the sinus floor using only platelet concentrates, which can improve the healing period and enhance bone regeneration by stimulating angiogenesis and bone formation. The main objective of this paper was to assess the effect of the sole use of platelet concentrates in sinus augmentation in terms of newly formed bone, augmented bone height, and clinical outcomes and to assess the additional beneficial effects of platelet-rich fibrin (PRF) in combination with other grafting biomaterials. Methods: A systematic review was conducted following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Pooled analyses were performed with the Review Manager software. Results: For sinus elevation only using platelet concentrates, 11 studies met the inclusion criteria and were included for qualitative synthesis. Only one study was a clinical trial, which reported improved outcomes for the allograft group compared to the titanium-PRF (T-PRF) group. A total of 12 studies where PRF was used in addition to grafting biomaterials met eligibility criteria and were included in the review. Results from meta-analyses provided no additional beneficial effects of PRF in sinus augmentation in terms of bone height and percentage of soft tissue area. There was a statistically significant lower percentage of residual bone substitute material in the PRF (+) group compared to the PRF (−) group. The percentage of newly formed bone was slightly higher in the PRF (+) group, but this was not statistically significant. Conclusion: There is no robust evidence to make firm conclusions regarding the beneficial effects of the sole use of platelet concentrates in sinus augmentation. However, studies have shown favorable outcomes regarding implant survival, bone gain, and bone height. The use of PRF with other grafting biomaterials appears to provide no additional beneficial effects in sinus lift procedures, but they may improve the healing period and bone formation. Well-conducted randomized clinical trials (RCTs) are necessary to confirm the available results to provide recommendations for the clinical practice.

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“…Ocho artículos 11,12,16,18-22 se relacionaron con la atrofia del maxilar e indicación de levantamiento de piso del seno maxilar con la técnica de Boyne y James 23 y Tatum 24 . Algunos estudios 11,16,[18][19][20][21][22] evaluaron el efecto del PRF en los procedimientos de ROG tratando en total 188 senos maxilares. Sus análisis histomorfométricos [20][21][22] indicaron que, al combinar hueso bovino con PRF, el porcentaje de formación ósea osciló entre el 18,35 % y el 35 %, mientras que al combinar aloinjerto óseo liofilizado con PRF, el porcentaje de formación ósea fue del 20,95 % 16 , sin obtener diferencias estadísticamente significativas.…”

Section: Resultsunclassified

“…Se conoce que los concentrados otorgan los factores de crecimiento al β-TCP. De esta forma la neoformación ósea aumentaría, aunque algunos estudios solo han encontrado entre el 19 y el 30 % de formación ósea [34][35][36][37] ; quizás porque no hay beneficio en el aumento de células, vasos capilares y nueva formación ósea, además de que los resultados encontrados a largo plazo no evidenciaron diferencias significativas con los grupos que utilizaron la mezcla PRF y β-TCP 18,38,39 .…”

Section: Discussionunclassified

Resultados del uso de la fibrina rica en plaquetas y rellenos óseos en la regeneración ósea guiada. Revisión sistemática

Muñoz

Castro-Rodríguez

2019

j.maxilo

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OriginalResultados del uso de la fibrina rica en plaquetas y rellenos óseos en la regeneración ósea guiada. Revisión sistemática *Autor para correspondencia: Correo electrónico: miguelnm8887@gmail.com (Miguel Ángel Núñez Muñoz).Objetivo: El propósito de esta revisión fue evaluar sistemáticamente la literatura científica sobre los resultados que se obtienen al combinar la fibrina rica en plaquetas (PRF) y rellenos óseos en la regeneración ósea guiada. Materiales y métodos:Búsqueda detallada en las bases de datos PubMed, Scopus, Web of Science, ScienceDirect, Cochrane y SciELO para obtener la información más actualizada de los resultados (grado de relleno óseo, éxito de la cirugía, movilidad del implante, complicaciones posquirúrgicas, supervivencia del implante) entre los casos tratados con PRF y los casos donde se combinó PRF con algún tipo de relleno óseo.Resultados: De las 965 publicaciones identificadas inicialmente, se excluyeron reportes clínicos, revisiones, estudios observacionales, etc. Se incluyeron 12 ensayos clínicos que contrastaron las variables entre la técnica con PRF solo y la combinación con un relleno óseo.Conclusión: La combinación entre PRF más rellenos óseos promueve la neoformación ósea, aumenta el trabeculado y mejora los tiempos de cicatrización; sin embargo, al cabo de 6 meses de control los resultados no son diferentes significativamente de los de los grupos que no utilizaron PRF en el procedimiento de levantamiento de piso de seno maxilar con técnica de ventana lateral. Respecto a la preservación de reborde alveolar, los distintos estudios no son concluyentes: algunos indican que la mezcla de PRF con un relleno óseo parece mejorar las proporciones volumétricas; sin embargo, otros refirieron pérdidas óseas en anchura e incluso mayor grado de inflamación.

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Histologic and histomorphometric assessment of sinus‐floor augmentation with beta‐tricalcium phosphate alone or in combination with pure‐platelet‐rich plasma or platelet‐rich fibrin: A randomized clinical trial

Abstract: These findings suggested that adding P-PRP or PRF to β-TCP graft substitute was not beneficial on new bone formation and regeneration, and P-PRP plus β-TCP or PRF plus β-TCP is not superior to β-TCP alone.

Cited by 62 publications

References 33 publications

Maxillary Ridge Vertical Augmentation Based on a Mixture of Xenogenic and Allogenic Bone Supported by Resorbable Membrane: One Case Report

Maxillary Ridge Vertical Augmentation Based on a Mixture of Xenogenic and Allogenic Bone Supported by Resorbable Membrane: One Case Report

Platelet-Rich Plasma in Maxillary Sinus Augmentation: Systematic Review

Resultados del uso de la fibrina rica en plaquetas y rellenos óseos en la regeneración ósea guiada. Revisión sistemática

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