Histologic and non-histologic factors correlated with survival time in supratentorial astrocytic tumors

Abstract

One hundred and ninety-two cases of supratentorial astrocytic tumors are classified in 4 groups according to the presence or absence in the pathological material of simple morphological criteria: abnormal cellular density, nuclear pleomorphism, neovascularization, necrosis. Each one of these criteria is strongly correlated with prognosis. Nevertheless only a simple classification in low and high grade lesions has a definite predictive value. A multivariate analysis utilizing Cox's hazard function confronts these histological findings with a number of clinical and etiological possible factors of prognosis. Age and performance status at the time of diagnosis are the best predictors of survival time. The clinical use of a predictive model derived from Cox's function analysis is discussed.

Clinicohistopathological study of astrocytomas along with Ki-67 proliferative index

“…8,9 In this study Anaplastic astrocytomas (grade III) mostly occurred in 4 th decade which correlated with study by Katsetos CD et al, Glioblastoma multiformae mostly occurred in 3 rd to 6 th decade, which correlated with the study by Thotakura M et al and Katsetos CD et al Strong influence of patient age on survival has been explained by the typical occurrence of aggressively behaving high grade astrocytomas at a somewhat later age and by decreased host resistance with age. [8][9][10] There was a highly significant correlation between the histopathological grade of astrocytomas and Ki-67 LI (p<0.01) This result agrees with the studies done by Ambroise et al, Thotakura M et al, Wakimoto et al (72 cases) (Table 4). 4,8,11 In a study by Montine et al using the previous monoclonal antibody and frozen sections, the Ki-67 LI was found to be a significant prognostic indicator for the entire group of astrocytomas and was more significantly related to survival than histological grade.…”

Chemotherapy for high-grade gliomas

“…Foremost among these is the likelihood that aggressive local growth is facilitated by intense angiogenesis. The issue of the prognostic significance of angiogenesis in glial neoplasm is complex and in need of further study as indicated by conflicting reports regarding its prognostic significance and further complicated by the fact that angiogenesis is by definition associated with increasing tumour grade and poor prognosis (Burger et al, 1985;Cohadon et al, 1985;Fulling and Gercia, 1985;Daums-Duportet al, 1988). A number of factors have been implicated in glioma angiogenesis including vascular endothelial growth factor (VEGF) (Plate et al, 1994), fibroblast growth factor (FGF) (Li et al, 1994), epidermal growth factor (EGF) (Folkman and Klagsbrun, 1987), transforming growth factors (TFG) (Folkman and Klagsbrun, 1987) and plateletderived growth factor (PDGF) (Folkman and Klagsbrun, 1987).…”

Neurosurgical considerations in supratentorial low-grade gliomas: experience with 175 patients

“…Different institutions use different classification systems usually not specifically described in the published series, and this makes comparisons difficult and produces wide variations in prognoses in the literature. [15] For example, Grade 2 lesions according to the Kernohan four-tiered system would be anaplastic astrocytomas in the three-tiered system proposed by Burger. [13] When the St. Anne/Mayo Clinic grading system [18] was used by Janny, et al, [31] tumor grade was the principal variable on which survival of patients with ordinary hemispheric astrocytomas depended.…”