Histologic and Ultrastructural Analysis of Regenerated Bone in Maxillary Sinus Augmentation Using a Porcine Bone–Derived Biomaterial

Abstract

According to our knowledge, this is the first study presenting data on TEM of a porcine bone-derived biomaterial used in sinus augmentation procedures in humans. Our findings show that this is a biocompatible biomaterial that can be used for maxillary sinus augmentation procedures without interfering with the normal reparative bone processes.

Clinical, histological and histomorphometrical study of maxillary sinus augmentation using cortico-cancellous fresh frozen bone chips

“…There are two basic surgical approaches for a sinus lift: lateral and crestal, and both of them are predictable techniques to restore sufficient bone volume for implant placement (Lazzara, 1996;Garg and Quinones, 1997;Woo and Le, 2004). Different graft materials have been proposed for sinus augmentation procedures, but it is still not clear which are the most suitable for bone regeneration (van den Bergh et al, 1998;Orsini et al, 2006). There have been experimental in vitro and in vivo studies in many animal models in order to assess the quality of bone defects filled with different test materials.…”

Histomorphometric Analysis of Maxillary Sinus Augmentation Using an Alloplast Bone Substitute

“…[6][7][8][9][10] The sinus lift procedure adequately increases the vertical dimension of the resorbed alveolar process in the posterior maxilla, thus making the placement of implants of sufficient length at this site possible. Grafting materials, including autogenous bone, 5,9 demineralized freeze-dried bone allograft, [11][12][13][14] mineralized freeze-dried bone allograft, 14 xenografts, [15][16][17][18][19] hydroxyapatite (HA) preparations, 7,15 calcium sulfate preparations, 20 and growth factors embedded in different carrier materials, [21][22][23] have been successfully used to augment the floor of the maxillary sinus.…”

SEM-EDX Study of the Degradation Process of Two Xenograft Materials Used in Sinus Lift Procedures

“…According to others studies, phase composition [78], chemical composition [79], porosity [80], the dispersant concentration on the pore morphology [58], particle size [81] the ultrastructural geometry of particles [82], surface roughness [83] and crystallinity [17], among others, are likely to affect ceramics solubility. Different applications require materials with distinct resorption rates [9], which may be adjusted for the desired purpose [84].…”

“…These findings marked the different resorption process stages. However, other research works [58] have used transmission electron microscopy of human biopsies following maxillary sinus elevation with porcine bone to show a few signs of resorption after 5 months. Their histological results indicated only the initial resorption of the biomaterial.…”