Histologic Characterization of Regenerated Tissues in Canal Space after the Revitalization/Revascularization Procedure of Immature Dog Teeth with Apical Periodontitis

Wang, Xiaojing; Thibodeau, Blayne; Trope, Martin; Lin, Louis M.; Huang, George T.‐J.

doi:10.1016/j.joen.2009.09.039

Cited by 377 publications

(369 citation statements)

References 25 publications

Supporting

Mentioning

300

Contrasting

Unclassified

Order By: Relevance

“…The results available in the literature, originating from both controlled animal studies 1,2 and clinical case reports, 3,4 leave no doubt that revascularization procedures are an important and feasible option in the treatment of immature teeth with necrotic pulps and periapical lesions. Revascularization allows for continued root development, in both length and thickness, reinforcing the radicular structure, and has the potential to decrease the risks of fracture, 3,4,5 treatment duration, and cost.…”

Section: Introductionmentioning

confidence: 99%

Tissue characterization following revascularization of immature dog teeth using different disinfection pastes

et al. 2016

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Tissue characterization following revascularization of immature dog teeth using different disinfection pastes

et al. 2016

View full text Add to dashboard Cite

“…28 Further histological research on dogs by this group has reported that the canal dentinal walls were thickened by the apposition of cementum-like tissue they termed 'intra-canal cementum'. 29 Despite these limitations of knowledge, these case reports show evidence of the success of regenerative endodontic procedures but the literature to date has only been low levels of evidence; case series and case reports. There have been only a few published reports that address success and failure of the regenerative procedure.…”

Section: Discussionmentioning

confidence: 99%

Regenerative endodontics – biologically‐based treatment for immature permanent teeth: a case report and review of the literature

Thomson

Kahler

2010

Australian Dental Journal

114

View full text Add to dashboard Cite

Background: A paradigm shift in the treatment of immature, necrotic teeth has occurred with biologically-based principles and regenerative endodontic protocols replacing traditional 'apexification' procedures. Preliminary research suggests that stem and progenitor cells from the pulp and ⁄ or periodontium contribute to continued root development when regenerative procedures are followed. Methods: A mandibular premolar tooth with a chronic periapical abscess was irrigated with sodium hypochlorite with minimal instrumentation and then dressed with tri-antibiotic paste consisting of ciprofloxacin, metronidazole and amoxicillin. At a subsequent visit a blood clot was evoked in the canal by irritating periapical tissues and the canal sealed with mineral trioxide aggregate, glass ionomer cement and composite resin. Results: Resolution of apical periodontitis and the draining sinus, continued root maturation and apical closure occurred over an 18-month period. The tooth became responsive to pulp sensibility testing. Conclusions: It is important that dentists recognize the potential of regenerative endodontics in the treatment of necrotic, immature teeth. Initial management should involve irrigation with sodium hypochlorite only. Intra-canal medicaments, such as calcium hydroxide, are contraindicated as they inhibit further root growth. This report uses a variation of the triantibiotic paste currently recommended for regenerative procedures that avoided the discolouration of the crown associated with current protocols. Regenerative endodontics with continued root growth may reduce the risk of fracture and premature tooth loss associated with traditional 'apexification' procedures where the root remains thin and weak.

show abstract

“…A modified antibiotic mixture consisting of ciprofloxacin, cerfuroxim and metronidazol (TVM; TreVitaMix, MedCem GmbH, Weinfelden, Switzerland) was further developed and later on primarily used for revascularisation in pediatric dentistry [20][21][22][23][24][25][26]. Such an antimicrobial agent could be an alternative way to sustainably reach pathogenic bacteria of the periodontium, provided that an adequate permeation through the dentine system is achieved.…”

Section: Introductionmentioning

confidence: 99%

Endodontic drug delivery for root surface disinfection: a laboratory feasibility evaluation

et al. 2015

View full text Add to dashboard Cite

OBJECTIVES This study aims to assess the potential of a mixture of three antibiotics (TreVitaMix, TVM) as an intracanal dressing to disinfect the outer root surface by applying a new in vitro model. MATERIALS AND METHODS Fifty freshly extracted bovine roots were endodontically treated. Forty samples were then thoroughly scaled, mounted to petri dishes, gas sterilized, and randomly allocated to four groups (n = 10/group) according to their intracanal medication: sterile saline (NaCl; control, A); the TVM carrier material alone, i.e., propylene glycol (PG; B); TVM (C); and calcium hydroxide (D). In an additional group (E), the cementum was not removed and TVM was placed. Petri dishes were filled with Fastidious Anaerobe Agar, inoculated with Fusobacterium nucleatum suspension and then anaerobically incubated during 48-h intervals at 37°C up to 192 h. Inhibition zones around the roots were then measured after each incubation period (mm(2)). RESULTS Only teeth inoculated with the TVM dressing showed inhibition at all time points, whereas the other treatments showed no peri-radicular growing inhibition. Presence of cementum had no negative effect on disinfection (p = 0.9320). CONCLUSION TVM was able to penetrate through the dentine and inhibit the bacterial growth of F. nucleatum up to 192 h. CLINICAL RELEVANCE TVM might have the potential to sustainably disinfect the outer root surface in perio-endo lesions and serve as an adjunctive antimicrobial agent. Declaration of interests:The authors declare they have no conflicts of interest. AbstractObjectives To assess the potential of a mixture of three antibiotics (TreVitaMix, TVM) as an intracanal dressing to disinfect the outer root surface applying a new in vitro model. Materials and MethodsFifty freshly extracted bovine roots were endodontically treated. Forty samples were then thoroughly scaled, mounted to petri dishes, gas sterilized and randomly allocated to four groups (n=10/group) according their intracanal medication: Sterile saline NaCl (control, A), the TVM carrier material alone, i.e. propylene glycol (PG; B), TVM (C) and calcium hydroxide (D). In an additional group (E), the cementum was not removed and TVM was placed. Petri dishes were filled with Fastidiuos Anaerobe Agar, inoculated with F. nucleatum suspension and then anaerobically incubated during 48 h intervals at 37°C up to 192 h. Inhibition zones around the roots were then measured after each incubation period (mm 2 ).Results Only teeth inoculated with the TVM dressing showed inhibition at all time points, whereas the other treatments showed no peri-radicular growing inhibition. Presence of cementum had no negative effect on the disinfection (p = 0.9320).Conclusion TVM was able to penetrate through dentine and inhibit the bacterial growth of F. nucleatum up to 192 h.Clinical relevance TVM might have the potential to sustainably disinfect the outer root surface in perio-endo lesions and serve as an adjunctive antimicrobial agent.

show abstract

Histologic Characterization of Regenerated Tissues in Canal Space after the Revitalization/Revascularization Procedure of Immature Dog Teeth with Apical Periodontitis

Cited by 377 publications

References 25 publications

Tissue characterization following revascularization of immature dog teeth using different disinfection pastes

Tissue characterization following revascularization of immature dog teeth using different disinfection pastes

Regenerative endodontics – biologically‐based treatment for immature permanent teeth: a case report and review of the literature

Endodontic drug delivery for root surface disinfection: a laboratory feasibility evaluation

Contact Info

Product

Resources

About