Histologic Examination of Teeth with Necrotic Pulps and Periapical Lesions Treated with 2 Scaffolds: An Animal Investigation

Histological assessment of regenerative endodontic treatment in animal studies with different scaffolds: A systematic review

“…A total of 54 animals were treated: 44 dogs, [10][11][12][13][14][15][16][17][18]21,22 six ferrets, 19 and four sheep. 20 Tooth types, numbers, and treatment protocols T A B L E 2 (Continued) applied to the teeth are summarized in Table 2 In six studies, 14,18-22 each tooth was considered to be an independent unit.…”

“…49 Nosrat et al also reported that the stem cells in the BC might not differentiate into odontoblasts, as they may be mobilized into the root canal from different sources other than the apical papilla, including bone marrow. 24 Thus, different tissue engineering strategies have been suggested, such as using scaffolds impregnated with growth factors, 12 platelet-rich plasma, 19 and a combination of dental pulp stem cells, 13 in an attempt to regenerate true pulp tissue.…”

“…1 Formation of intracanal hard tissue was reported in 80% of the studies which used BC scaffold, and 100% of the studies which used alternative scaffolds. Because of the lack of information in the published studies regarding the number of the teeth which showed intracanal hard tissue, it was difficult to determine precisely whether 18 [n=9T] Thibodeau et al 22 [n=NR] Tawfik et al 12 [n=NR] Yoo et al 15 [n=NR] Torabinejad et al 19 [n=2T]…”

“…[n=NR] Zhu et al 13 [n=10C] Yoo et al 15 [n=16C] Londero et al 17 [n=17C] Torabinejad et al 19 [n=2T]…”

Alternativas clínicas para el tratamiento de dientes traumatizados con rizogénesis incompleta: una visión actualizada

“…Frente a esta situación, la utilización de plasma rico en plaquetas (PRP) ha sido estudiada, mostrando un gran potencial para utilización como scaffold para la revascularización (44,45). El PRP tiene un volumen de plasma autólogo con altas concentraciones de plaquetas y de factores de crecimiento que promueven la proliferación de células madre (46,47).…”