Histologic Examinations of Teeth Treated with 2 Scaffolds: A Pilot Animal Investigation

Torabinejad, Mahmoud; Faras, Hadi; Corr, Robert; Wright, Kenneth R.; Shabahang, Shahrokh

doi:10.1016/j.joen.2013.12.025

Cited by 59 publications

(52 citation statements)

References 32 publications

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“…To harvest the blood in preparation of PRP, the same procedure in a previous study was used (8). MTA was gently placed on top of the PRP, followed by glass ionomer as described above.…”

Section: Methodsmentioning

confidence: 99%

“…Two reports found evidence of pulp-like loose connective tissue (4,5), and one reported an ingrowth of cementum, bone, and connective tissue (6). Animal studies examining regeneration procedures have shown that the types of tissues found within the root are not pulp but consist of bone, cementum, and connective tissue (7)(8)(9)(10)(11).…”

mentioning

confidence: 99%

“…Gelfoam combined with a blood clot and PRP have been studied separately as scaffolds in regenerative endodontics, but no study has compared the 2 scaffolds directly. In a previous investigation Torabinejad et al (8) histologically examined the types of tissues generated in noninfected ferret teeth by using 2 scaffolds. They reported growth of bone-like material into the root canals of these teeth.…”

mentioning

confidence: 99%

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Histologic Examination of Teeth with Necrotic Pulps and Periapical Lesions Treated with 2 Scaffolds: An Animal Investigation

Torabinejad

Milan

Shabahang

et al. 2015

Journal of Endodontics

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“…To harvest the blood in preparation of PRP, the same procedure in a previous study was used (8). MTA was gently placed on top of the PRP, followed by glass ionomer as described above.…”

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Histologic Examination of Teeth with Necrotic Pulps and Periapical Lesions Treated with 2 Scaffolds: An Animal Investigation

Torabinejad

Milan

Shabahang

et al. 2015

Journal of Endodontics

Self Cite

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“…Many studies have found clinical success following revascularization procedures, for example, no symptoms and no periapical lesions [81] [82]. However, the histological observations from animal experiments have revealed that the tissues formed in the root canal do not reflect the regeneration of pulp-dentin but are rather formed of periodontal tissues, such as cementum, periodontal ligament, and bone [83]. The revascularization procedure has its own clinical advantages in the treatment of immature teeth, but it does not result in pulp-dentin complex regeneration in the true sense.…”

Section: Animal Studiesmentioning

confidence: 99%

The Current Status of Stem Cell Regeneration in Intra Oral Applications—A Systematic Review

Kanwal¹,

D’souza²,

Muthiah³

et al. 2017

OJST

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Aim: 1) To review the literature of various applications of stem cell regeneration in dentistry from 2010 to 2016. 2) To review these studies and to summarize the current status of stem cell regeneration in intra oral applications.3) To present the available successful data with regard to stem cell regeneration in dentistry and to highlight the future trends. Materials and Methods: Search Protocol: A systematic search was made in the PubMed database with the key words gingiva, papillary reconstruction, periodontal ligament, dental pulp, salivary gland, enamel re-mineralization, dentin, cementum, bone, whole tooth, cleft palate, regeneration and stem cells. All articles from 2010 to 2016, relevant to the topic were included. After the search a total of 1826 articles were obtained which were screened and categorized by three independent reviewers as review papers, in vitro, animal and human studies, pertaining to stem cell regeneration in intra oral applications. On the basis of the extracted data and outcome measures, conclusions were drawn. Results: Maximum number of animal studies has been done to regenerate periodontal tissues, bone, dentin and pulp tissues. Few human studies have been done till date. Although clinically, researchers have been able to regenerate periodontal-like tissue, bone and pulp-like tissue, they still haven't been able to regenerate tissues that completely resemble tissues in their natural form. Conclusion: The future of stem cell therapy in dental applications looks promising. The predictability and efficacy of outcomes, as well as safety concerns of stem cell therapy is yet to be fully established. Ongoing research and development of newer scaffolds, understanding various signaling molecules and their cues, understanding gene expression and proteomics of stem cells are the future directions that will take us a step forward to achieving successful regeneration.

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“…the use of Platelet Rich Plasma (PRP) There have been numerous case reports on the use of PRP for regenerative endodontic procedures [51][52][53][54][55][56] . PRP basically acts as a scaffold and the basic premise for its use is that plasma which is segregated from whole blood is rich in platelets and growth factors and its insertion into the root canal provides for a more predictable quality and concentration of fibrin clot and associated growth factors.…”

Section: Regenerative Endodontic Procedures Withmentioning

confidence: 99%

Regenerative Endodontics: An Evidence Based Review

Gupta¹,

Gada²,

Shetty³

2015

J Cont Med A Dent

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Histologic Examinations of Teeth Treated with 2 Scaffolds: A Pilot Animal Investigation

Cited by 59 publications

References 32 publications

Histologic Examination of Teeth with Necrotic Pulps and Periapical Lesions Treated with 2 Scaffolds: An Animal Investigation

Histologic Examination of Teeth with Necrotic Pulps and Periapical Lesions Treated with 2 Scaffolds: An Animal Investigation

The Current Status of Stem Cell Regeneration in Intra Oral Applications—A Systematic Review

Regenerative Endodontics: An Evidence Based Review

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