Histologic grade and karyotype of immature teratoma of the ovary

Ihara, Toshihiko; Ohama, Koso; Satoh, Hideo; Fujii, Tsuneo; Nomura, Kazushi; Fujiwara, Atsushi

doi:10.1002/1097-0142(19841215)54:12<2988::aid-cncr2820541229>3.0.co;2-u

Cited by 42 publications

(10 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…56 In fact, immature ovarian teratoma usually shows only relatively minor cytogenetic abnormalities, in contrast to the other forms of malignant ovarian germ cell tumor, with increasing abnormalities as the grade of the immaturity becomes higher. 57 On the other hand, since testicular teratomas in postpubertal patients represent the end stage of a differentiation process from other types of malignant germ cell tumor, it is immaterial if 'immaturity' is present. Immaturity, in a sense, is 'trumped' by the invasive malignant germ cell tumor from which the teratoma derived in the postpubertal testis.…”

Section: Immature Teratoma and Selected Monodermal Teratomasmentioning

confidence: 99%

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues

2005

View full text Add to dashboard Cite

Section: Immature Teratoma and Selected Monodermal Teratomasmentioning

confidence: 99%

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues

2005

View full text Add to dashboard Cite

“…Auch wurden Amplifikationen des Protoonkogens N-myc in IT nachgewiesen (23). Die Mehrzahl der analysierten IT waren jedoch zytogenetisch unauffällig (20,22,28) oder wiesen keine konstanten numerischen Chromosomenanomalien auf (20,22,36). Weitere Fälle müssen analysiert bzw.…”

Section: Seminome Dysgenninome Und Embryonale Karzinomeunclassified

Zytogenetische Aspekte pädiatrischer Keimzelltumoren

Stock¹,

Ambros²,

Strehl³

et al. 1995

Klin Padiatr

View full text Add to dashboard Cite

We have performed in situ hybridization (ISH) studies predominantly on paraffin sections and on isolated nuclei of 22 pediatric germ cell tumors (GCTs) from 18 patients including 4 recurrences from three patients. In addition, we performed conventional cytogenetic analyses in three tumor samples. Because reports on cytogenetic studies in pediatric GCTs are scarce we focused our studies on those chromosome abnormalities frequently observed in adult GCTs. These included numeric and structural abnormalities of chromosomes 1 and 12 (e.g. isochromosome 12p) and numeric deviations of chromosomes 8, 10, X and Y. The histological subsets of the tumors investigated included two dysgerminomas (DGE), one seminoma (SE), one combined seminoma, two embryonal carcinomas (EC), two recurrent ECs, six pure yolk sac tumors (YST), five combined teratomas, one immature teratoma (IT) and two recurrences of IT, and three differentiated teratomas (TD). Similar to the GCTs in adults, additional copies of chromosome 12 were the most frequently observed numeric abnormalities. The analysis of two paraffin-embedded tumors suggested that changes in the size of the pericentromeric hybridization signals of chromosome 12 may be attributed to the presence of i(12)(p10). This was confirmed following the karyotype analysis of one EC which unequivocally revealed the presence of two i(12)(p10). Interestingly, using these probes, no chromosomal abnormalities were found in the pure TD or in the TD cells of mixed tumors containing a YST component. In the YST portion, however, the 1p deletions and/or numeric chromosome changes were present. Surprisingly, deletions at the short arm of chromosome 1, del(1)(p36.3), were frequently observed in malignant pediatric GCTs and were the sole abnormality detected in one case.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

“…Reports on cytogenetic studies of pediatric G C T are scarce. A few cases of differentiated teratomas ( T D ) (Hecht et al, 1984;Ishiwata et al, 1991;Speleman et al, 1992), undifferentiated teratomas (IT) (Ihara et a]., 1984;Surti et al, 1990), one I T with focal germinoma and embryonal carcinoma (EC) components (Shen et al, 1990), and one yolk sac tumor (YST) (Speleman et al, 1990) were analyzed. Two of the reports described an i(12p) (Speleman et al, 1990(Speleman et al, , 1992 and structural aberrations of chromosome 1, respectively (Hecht et al, 1984;Shen et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Detection of numerical and structural chromosome abnormalities in pediatric germ cell tumors by means of interphase cytogenetics

Stock

Ambros

Lion

et al. 1994

Genes Chromosomes & Cancer

View full text Add to dashboard Cite

In contrast to the cytogenetically well characterized testicular germ cell tumors (GCT) in adults, reports on cytogenetic studies in pediatric GCT are scarce. The presence of an i(12p) and numerical abnormalities involving chromosome 12 are the most frequent cytogenetic changes in GCT of adults. We have performed in situ hybridization (ISH) studies on paraffin sections and on isolated nuclei of 13 pediatric GCT with particular emphasis on those chromosome abnormalities that are common in adult GCT. These include numerical and structural abnormalities of chromosomes 1 and 12 as well as numerical deviations of chromosomes 8, 10, X, and Y. The histological subsets of the tumors investigated included two dysgerminomas (DGE), one seminoma (SE), two embryonal carcinomas (EC), four mixed and two pure yolk sac tumors (YST), and one undifferentiated (IT) and one differentiated teratoma (TD). Similar to the GCT in adults, additional copies of chromosome 12 were the most frequently observed numerical abnormalities. In contrast to the findings in adult GCT, changes in the size of the pericentromeric hybridization signals of chromosome 12, suggesting the presence of i(12p) chromosomes, were found in only two cases. No chromosome abnormalities were found in the pure TD or in the TD cells of mixed tumors containing a YST component. In the YST portion, however, Ip deletions and/or numerical chromosome changes were present. Surprisingly, deletions of the short arm of chromosome I, del(I)(p36.3), were frequent in pediatric GCT and were the sole abnormality detected in two cases. The Ip36 deletions were present in all stage-IV EC and YST investigated and were absent in the relatively benign TD and in one YST stage-I. Therefore, Ip36 deletions may have value as a prognostic marker in pediatric GCT.

show abstract

Histologic grade and karyotype of immature teratoma of the ovary

Cited by 42 publications

References 15 publications

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues

Zytogenetische Aspekte pädiatrischer Keimzelltumoren

Detection of numerical and structural chromosome abnormalities in pediatric germ cell tumors by means of interphase cytogenetics

Contact Info

Product

Resources

About