Histologic prognostic factors in ependymoma

Schiffer, Davide; Chiò, Adriano; Giordana, Maria Teresa; Migheli, Antonio; Palma, Lucio; Pollo, Bianca; Soffietti, Riccardo; Tribolo, Antonella

doi:10.1007/bf00249392

Cited by 143 publications

(77 citation statements)

References 21 publications

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“…Histological features of anaplasia, such as mitoses, microvascular proliferation and necrosis, serve as indicators of biological behaviour in other gliomas, including diffuse astrocytic tumours and oligodendrogliomas (Cohadon et al, 1985;Burger and Green, 1987;Ellison, 1998). However, the biological significance of these morphological features in ependymoma remains unclear; clinicopathological studies have provided conflicting evidence on the prognostic value of dividing ependymomas into classic (WHO grade 2) and anaplastic (grade 3) variants (Ross and Rubinstein, 1989;Sutton et al, 1990;Schiffer et al, 1991;Gerszten et al, 1996;Bouffet et al, 1998;Figarella-Branger et al, 2000).…”

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confidence: 99%

Genetic abnormalities detected in ependymomas by comparative genomic hybridisation

et al. 2002

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Using comparative genomic hybridisation, we have analysed genetic imbalance in a series of 86 ependymomas from children and adults. Tumours were derived from intracranial and spinal sites, and classified histologically as classic, anaplastic or myxopapillary. Ependymomas showing a balanced profile were significantly (P50.0005) more frequent in children than adults. Profiles suggesting intermediate ploidy were common (44% of all tumours), and found more often (P50.0005) in tumours from adults and the spinal region. Loss of 22q was the most common specific abnormality, occurring in 50% of spinal (medullary) ependymomas and 26% of tumours overall. Genetic profiles combining loss of 22q with other specific abnormalities -gain of 1q, loss of 6q, loss of 10q/10, loss of 13, loss of 14q/14 -varied according to site and histology. In particular, we showed that classic ependymomas from within the cranium and spine have distinct genetic profiles. Classic and anaplastic ependymomas with gain of 1q tended to occur in the posterior fossa of children and to behave aggressively. Our extensive data on ependymomas demonstrate significant associations between genetic aberrations and clinicopathological variables, and represent a starting point for further biological and clinical studies.

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Genetic abnormalities detected in ependymomas by comparative genomic hybridisation

et al. 2002

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“…The 2007 WHO classification of CNS tumors places ependymoblastoma within the spectrum of PNETs with the capacity to differentiate along one or more cell lines and explicitly defines it as a tumor "with ependymoblastic rosettes." 9,23,28 Within this classification, ependymoblastoma has clear cytogenetic and histological characteristics that allow its differentiation from medulloblastomas and other PNETs.…”

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Ependymoblastoma with cystic change in a child

Ding

Zhao

Qiu

et al. 2014

PED

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Ependymoblastoma is a rare and devastating primitive neuroectodermal tumor with ependymal differentiation. This tumor occurs very early in life and shows rapid growth and a diffuse infiltration through the leptomeningeal space. This neoplasm is characterized by uniform neuroepithelial cells, multilayered ependymal rosettes, perivascular pseudorosettes, and numerous mitotic figures. In this article, the authors report on a 4-year-old girl who was diagnosed as having an ependymoblastoma with cystic change. After a series of laboratory and imaging examinations, the left frontal solid-cystic lesion was surgically excised. Histological examinations confirmed the diagnosis of ependymoblastoma. The patient's intracranial hypertension symptoms were alleviated, and postoperative chemotherapy was performed. At the 6-month follow-up visit, MRI demonstrated evidence of relapse, and the girl died of tumor recurrence 14 months after surgery. Databases (PubMed, MEDLINE, Embase, and Web of Science) were searched for relevant articles published from 1970 to 2012; 71 eligible cases of ependymoblastoma were obtained, and 42 provided complete clinical details. Prognosis of children with ependymoblastoma is poor, and data on clinical behavior and optimal treatment strategies are lacking, but sustained remissions have been achieved after multimodal treatment according to existing literature. In this report, the clinical and histopathological features and therapeutic options of this tumor are discussed in the light of the published data. Further studies, especially those examining multimodality therapy, are needed to improve survival of children with this rare malignant CNS tumor.

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“…Ependimomas são neoplasias de celularidade moderada, com morfologia nuclear monótona 1,2,4,6,8,11,12 . Os principais achados são as rosetas ependimárias, representadas por células colunares dispostas em torno de um canal central, e as pseudo-rosetas perivasculares, constituídas de células neoplásicas circunjacentes aos vasos 1,2,4,6,8,11,12 .…”

Section: Fig 5 Corte Histológico De Ependimoma Composto Por Células unclassified

“…Os principais achados são as rosetas ependimárias, representadas por células colunares dispostas em torno de um canal central, e as pseudo-rosetas perivasculares, constituídas de células neoplásicas circunjacentes aos vasos 1,2,4,6,8,11,12 . Degeneração mixóide, calcificação, necrose e focos de hemorragia podem ser observados 1,2,4,6,8,11,12 . Nas formas anaplásicas há aumento da celularidade, mitoses, proliferação vascular e por vezes focos de necrose 8 (Fig 5).…”

Section: Fig 5 Corte Histológico De Ependimoma Composto Por Células unclassified

Ependimomas: achados clínicos, epidemiológicos e anatomopatológicos de 22 casos

Torres

Filho²,

Netto³

et al. 1999

Arq. Neuro-Psiquiatr.

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RESUMO -Ependimomas são neoplasias compostas por células ependimárias neoplásicas, manifestando-se predominantemente em crianças e adultos jovens. Relatamos os achados clínicos, epidemiológicos e anatomopatológicos de 22 casos de ependimomas. Dos 22 casos analisados, 14 ocorreram em pacientes do sexo masculino e 8 em pacientes femininos. As idades variaram de 1 a 58 anos, com média de 24,63 anos. Quanto à localização, 10 casos acometeram medula, 7 ocorreram em hemisférios cerebrais, 2 intraventriculares e 1 no tronco cerebral. Os sinais e sintomas observados incluiram redução da força muscular (59,1% dos pacientes), alterações da marcha (36,3%), alterações da sensibilidade(36,3%), hiperreflexia e sindrome de hipertensão endocraniana, com período de evolução variando de 15 dias a 8 anos, com média de 17,58 meses. Sete pacientes foram submetidos a ressecção cirúrgica total , 7 a exérese parcial, 4 a exérese parcial associada a radioterapia adjuvante, 3 a ressecção parcial seguida de quimioterapia e 1 a tumorectomia total associada a radioterapia. Evidenciou-se taxa de recidiva tumoral total de 18,2%. Estes achados aproximam-se dos encontrados na literatura internacional, corroborando para a compreensão do comportamento biológico deste tumor. PALAVRAS-CHAVE: ependimomas, neoplasias do sistema nervoso central, tumores cerebrais. Ependymonas: clinical, epidemiological and pathological findings of 22 casesABSTRACT -Ependymomas are composed of neoplastic ependymal cells, affecting mainly children and young adults. We report the clinical and pathological findings of 22 cases of ependymomas. Fourteen patients were males and 8 were females. The ages ranged between 1 and 58 years, with a mean of 24.63 years. The symptoms reflected the growth and topography of the tumours; muscle weakness (59.1%), gait disorders (36.3%), sensitive disorders (36.3%), hyperreflexia and intracranial hypertension syndrome were the most frequent symptoms. Ten tumours affected the medulla, 7 the cerebral hemispheres, 2 the cerebral ventricles and 1 brain stem. Seven patients were submitted total resection of the tumor, from which one received adjuvant radiotherapy. 15 other patients were submitted to partial resection; from which 4 received adjuvant radiotherapy, 3 adjuvant chemotherapy and 1 chemotherapy and radiotherapy. The recurrence rate was 18.2%. These results are similar with the literature and may contribute to further understanding the biological behavior of these tumours.KEY WORDS: ependymomas, central nervous system tumours, brain tumours.Os ependimomas se originam da camada ependimária que recobre os ventrículos cerebrais e o canal central da medula espinhal, manifestando-se em crianças e adultos jovens, com características morfológicas e comportamento biológico extremamente variáveis [1][2][3][4] . Relatamos os achados

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Histologic prognostic factors in ependymoma

Cited by 143 publications

References 21 publications

Genetic abnormalities detected in ependymomas by comparative genomic hybridisation

Genetic abnormalities detected in ependymomas by comparative genomic hybridisation

Ependymoblastoma with cystic change in a child

Ependimomas: achados clínicos, epidemiológicos e anatomopatológicos de 22 casos

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