Histological and Biochemical Effects of Cigarette Smoke on the Liver of Wistar Rats

Ogenyi, Samuel Ifedioranma; Choji, Tobias; Chimezirim, A.; Onyemelukwe, Anulika Obianuju; Ngokere, A.; Onwuasoanya, U.; Akulue, Justina Chimezie

doi:10.9734/arrb/2015/17292

Cited by 5 publications

(2 citation statements)

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“…The increase of AST levels in the serum indicate alterations in the enzymatic activity of the liver. In support of our results, it has been shown that AST levels can be significantly increased after mice are exposed to THS for 6 months and rats that are exposed to SHS for 4 weeks also show elevated AST (Ogenyi et al, 2015).…”

Section: Discussionsupporting

confidence: 91%

Biological markers of harm can be detected in mice exposed for two months to low doses of Third Hand Smoke under conditions that mimic human exposure

Chen

Adhami

Martins‐Green

2018

Food and Chemical Toxicology

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Section: Discussionsupporting

confidence: 91%

Biological markers of harm can be detected in mice exposed for two months to low doses of Third Hand Smoke under conditions that mimic human exposure

Chen

Adhami

Martins‐Green

2018

Food and Chemical Toxicology

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“…Evidence attributes hepatocellular damage to the action of nicotine and its main metabolite, cotinine, which induce liver toxicity and hepatocellular apoptosis through direct, indirect, immunological, and oncogenic effects. The direct toxic effect of nicotine and cotinine is related to increased oxidative stress, lipid peroxidation, hepatocyte degradation, and DNA damage by free radicals generated by the rupture of the mitochondrial respiratory chain, and all cause hepatocellular damage (El-Sherbeeny et al, 2016;El-Zayadi, 2006;Husain et al, 2001;Ogenyi et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Probiotics, prebiotics and symbiotics attenuate chronic effects of passive smoking on physiological and biochemical parameters in rats: A randomized and controlled study

Rombi

Lopes

Ortiz

et al. 2021

RSD

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Passive and chronic exposure to tobacco smoke is a major cause of preventable diseases in humans and animals. The aim of this study was to evaluate the physiological and biochemical effects of functional foods: probiotics, prebiotics, and symbiotics in young rats exposed chronically to cigarette smoke. Ninety-six young male rats were randomly assigned to eight groups (n = 12): control (C); probiotic (Pro); prebiotic (Pre); symbiotic (Sym); smoking control (CS); smoking probiotic (ProbS); smoking prebiotic (PrebS); and smoking symbiotic (SymbS). After the experimental period of 189 days, the animals were anesthetized, blood samples were collected, and the animals were euthanized by exsanguination. The data were submitted to the Shapiro Wilk test, followed by the one-way ANOVA test, with contrasts by the Tukey method (P<0.05). The results demonstrated that chronic passive exposure to cigarette smoke had deleterious effects on the animals, and that these effects were attenuated in groups of animals supplemented with functional foods. In the supplemented groups there were significant improvements in weight gain, and mean values of liver enzymes (ALT, AST, GGT, and ALP), serum proteins (albumin and globulins), blood glucose, uremia, and creatininemia. We conclude that functional foods, probiotics, prebiotics, and symbiotics, attenuate the deleterious effects on the physiological and biochemical parameters of rats chronically exposed to cigarette smoke.

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Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke

Machado-Junior

Araújo

Souza

et al. 2020

BioMed Research International

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Cigarette smoke is highly toxic, and it can promote increased production of reactive species and inflammatory response and leads to liver diseases. Quercetin is a flavonoid that displays antioxidant and anti-inflammatory activities in liver diseases. This study aimed at evaluating the protective effects of quercetin on livers from mice exposed to long-term cigarette smoke exposure. Male C57BL/6 mice were divided into five groups: control (CG), vehicle (VG), quercetin (QG), cigarette smoke (CSG), quercetin, and cigarette smoke (QCSG). CSG and QCSG were exposed to cigarette smoke for sixty consecutive days; at the end of the exposures, all animals were euthanized. Mice that received quercetin daily and were exposed to cigarette smoke showed a reduced influx of inflammatory cells, oxidative stress, inflammatory reaction, and histopathological changes in the liver, compared to CSG. These results suggest that quercetin may be an effective adjuvant for treating damage to the liver due to cigarette smoke exposure.

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Histological and Biochemical Effects of Cigarette Smoke on the Liver of Wistar Rats

Cited by 5 publications

References 0 publications

Biological markers of harm can be detected in mice exposed for two months to low doses of Third Hand Smoke under conditions that mimic human exposure

Biological markers of harm can be detected in mice exposed for two months to low doses of Third Hand Smoke under conditions that mimic human exposure

Probiotics, prebiotics and symbiotics attenuate chronic effects of passive smoking on physiological and biochemical parameters in rats: A randomized and controlled study

Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke

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