Histological and biochemical effects of Arteether&lt;sup&gt;tm&lt;/sup&gt; on the liver of wistar rats

Okunlola, A.I.; Okunlola, CK; Okani, Chukwudi Onyeaghana; Adewole, Olarinde S.; Ojo, S.K.; Abiodun, A.A.; Bejide, Ronald; Ojewole, AO

doi:10.4314/ajtcam.v10i4.25

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Protein synthesis in the liver may be affected by any chemical with either moderate or extensive hepatotoxic effects, such as those produced by plasmodium or antimalarials. Most drugs bind to albumin and globulins . Our results (Figures and ), showing a significant difference in total protein but no significant decrease in albumin concentration, suggest a mild adverse effect of artemether.…”

Section: Resultsmentioning

confidence: 45%

Comparative effects of parenteral antimalarials in Swiss albino mice after chronic exposure to Plasmodium berghei

Aghahowa

Okolocha

2018

Anim Models and Exp Med

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Mice are considered to be a similar model to humans in the pathogenesis of malaria. This study evaluates the effect of parenteral antimalarials on the spleen and liver of Swiss albino mice after chronic exposure to Plasmodium berghei . After chronic exposure to P. berghei NK 65 strain, the level of parasitemia was assessed. The mice were treated for 3 days using chloroquine (5 mg/kg), quinine (10 mg/kg), and artemether (2 mg/kg). The effect of chronic exposure and the pattern of recovery were evaluated. There was significant decrease in total body weight after chronic exposure to P. berghei ( P < 0.05). An increase in total weight recovery was seen after day 15 of treatment with the antimalarials; this was more pronounced with artemether. A significant increase in liver and spleen weights due to P. berghei infection was seen. There was a recovery pattern due to decrease in liver and spleen weights following antimalarial administration, which was greatest with artemether ( P < 0.05). Significant changes were more in parasitized, quinine and artemether groups ( P < 0.05). There was a significant decrease in total spleen protein due to chloroquine but a decrease due to quinine and artemether ( P < 0.05). No significant changes in liver and spleen albumin were observed after treatment. The highest parasite clearance was observed with artemether, followed by quinine. Five mice died after chronic exposure in all the groups prior to treatment. There was significant enlargement and discoloration of spleen and liver after chronic exposure. This study showed that artemether aided recovery of the liver and spleen better than quinine and chloroquine in albino mice after chronic exposure to P. berghei . This suggests there is potential for improvement in antimalarial therapy.

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Section: Resultsmentioning

confidence: 45%

Comparative effects of parenteral antimalarials in Swiss albino mice after chronic exposure to Plasmodium berghei

Aghahowa

Okolocha

2018

Anim Models and Exp Med

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“…It is a well-known medicinal plant that has been utilized for a number of purposes, including malaria, for centuries. It is a fast acting blood schizonticidal drug specifically meant for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cases of cerebral malaria (Okunlola et al, 2013). Several semisynthetic derivatives of artemisinin have been used increasingly over the past two decades as antimalarials.…”

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confidence: 99%

Efficacy of Arteether Against Theileriosis in Cattle

Khawale¹

2019

JAR

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The present study was done with the objective of comparative efficacy of arteether and buparvaquone against theileriosis in cattle. Total 67 cattle suspected for theileriosis were screened on the basis of clinical and blood smear examination. Group I (n=6) was treated with Inj. buparvaquone @ 2.5 mg/kg body weight once and Group II (n=6) was treated with Inj. arteether @5 mg/ kg body weight intramuscularly for three consecutive days. Rectal temperature, heart rate and respiration rate were significantly increased before treatment and in both the groups after treatment showed significant improvement. Haematological parameters showed significant decreased in Hb, PCV, TEC, TLC and neutrophil and significant increase in lymphocytes, monocytes and eosinophil. Non significant difference in basophil count was observed. After treatment, significant improvement was observed in mean hemoglobin, PCV, TEC, TLC, neutrophil, lymphocyte and eosinophil. Non significant improvement was observed in monocyte and basophil count. Present study revealed percent efficacy of arteether was 66.66% and buparvaquone 100%.

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