Histological and biomechanical evaluation of implanted graft materials in a rabbit vaginal and abdominal model

Hilger, Wesley S.; Walter, Andrew J.; Zobitz, Mark E.; Leslie, Kevin O.; Magtibay, Paul M.; Cornella, Jeffrey L.

doi:10.1016/j.ajog.2006.07.006

Cited by 56 publications

(62 citation statements)

References 17 publications

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“…Size-wise, the lower limit of experimental vaginal surgery is the adult rabbit, whereas sheep may be a closer mimic to the clinical conditions of POP surgery. In rabbits, successful insertion of implants in the posterior vagina has been described, but grafted material is by definition small [27][28][29][30][31][32][33]. In contrast to abdominal repairs, rabbit vaginal repairs with mesh result in exposure rates as high as 50%, which is far above that reported clinically [30,31,34,35].…”

Section: Purpose and Design Of Animal Models And Experimentsmentioning

confidence: 77%

A standardized description of graft-containing meshes and recommended steps before the introduction of medical devices for prolapse surgery

et al. 2012

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Over the past decade, a huge number of new implants and ancillary devices have been introduced to the market. Most of these have become clinically available with little or no clinical data or research. This is a less-than-ideal situation, and this subgroup of the ad hoc IUGA roundtable conference wants to open the discussion to change this, by proposing a pragmatic minimum clearance track for new products being introduced to the market. It consists of an accurate and more standardized product description, data on the biological properties gathered in animal experiments, anatomical cadaveric studies, and upfront clinical studies followed by a compulsory registry on the first 1,000 patients implanted. Ideally, manufacturers should support well-designed prospective (randomized) clinical trials that can support the claimed benefits of the new product.

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Section: Purpose and Design Of Animal Models And Experimentsmentioning

confidence: 77%

A standardized description of graft-containing meshes and recommended steps before the introduction of medical devices for prolapse surgery

et al. 2012

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“…One more limitation may be found in the choice of an abdominal animal model for the study of vaginal implants. In fact, in a rabbit model, histological and biomechanical differences between abdominal and vaginal implantations were noted [31]. On the other hand, no biomechanical differences were noted when a synthetic material was implanted on the abdomen and in the vagina of a sheep model [32].…”

Section: Discussionmentioning

confidence: 98%

Stem cell augmented mesh materials: an in vitro and in vivo study

et al. 2014

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“…Does this explain why some women respond more favorably after implantation of an allograft to augment a pelvic organ prolapse surgical repair? Animal studies suggest that prolapse repairs incorporating a synthetic allograft may yield higher vaginal stiffness index values than other types of graft material [15,16]. Further research is needed to determine if biomechanical properties of the vagina change after prolapse surgery with or without allograft augmentation and if symptom improvement correlates with the extent of change in in vivo vaginal biomechanical properties.…”

Section: Discussionmentioning

confidence: 99%

Correlation between vaginal stiffness index and pelvic floor disorder quality-of-life scales

Epstein¹,

Graham²,

Heit³

2008

Int Urogynecol J

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The objective of this study was to determine if vaginal stiffness index, an in vivo vaginal biomechanical property, is correlated with pelvic floor disorder symptom distress, impact on quality of life, or sexual function as measured by disease-specific quality-of-life scales. Forty-eight women completed validated quality-of-life scales (pelvic floor distress inventory-short form, pelvic floor impact questionnaire, and pelvic organ prolapse/urinary incontinence sexual questionnaire) and underwent in vivo vaginal biomechanical testing. After bivariate relationships between vaginal stiffness index and demographic, obstetric, and gynecologic variables were explored, multiple linear regression controlling for pelvic organ prolapse quantitative (POP-Q) stage of prolapse was performed. The vaginal stiffness index was inversely correlated with pelvic organ prolapse distress severity (POPDI-6) after controlling for POP-Q stage of prolapse (p = 0.011, r = 0.67, r (2) = 0.450, beta = -2.3). These findings provide initial evidence for the construct validity of in vivo vaginal biomechanical testing for pelvic organ prolapse evaluation because an increasing vaginal stiffness index is correlated with decreasing symptomatic and anatomic severity of disease.

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Histological and biomechanical evaluation of implanted graft materials in a rabbit vaginal and abdominal model

Cited by 56 publications

References 17 publications

A standardized description of graft-containing meshes and recommended steps before the introduction of medical devices for prolapse surgery

A standardized description of graft-containing meshes and recommended steps before the introduction of medical devices for prolapse surgery

Stem cell augmented mesh materials: an in vitro and in vivo study

Correlation between vaginal stiffness index and pelvic floor disorder quality-of-life scales

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