Histological and biomechanical studies of two bone colonizable cements in rabbits

Lu, Jianxi; About, Imad; Stephan, Grégory; Landuyt, P. Van; Déjou, Jacques; Fiocchi, Maria F.; Lemaître, Jonathan; Proust, Jean‐Pierre

doi:10.1016/s8756-3282(99)00131-3

Cited by 24 publications

(16 citation statements)

References 17 publications

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“…23 Some researchers reported that the compressive strength of the cancellous bone is about 3.75 MPa, and the elastic modulus of the cancellous bone is about 1.75 GPa. 24 In this study, the compressive strength and the elastic modulus of the CPC-FG specimens at the P/L ratio of 1:1 (g/mL) were the closest to those of cancellous bone in the four groups. In this study, the surgical area was the femoral condyle of the rabbit, and the implanted material was surrounded by the cancellous bone in vivo.…”

Section: Discussionmentioning

confidence: 54%

The mechanical and biological studies of calcium phosphate cement-fibrin glue for bone reconstruction of rabbit femoral defects

Dong¹,

Geng²,

Bi³

et al. 2013

IJN

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Abstract:In order to improve the mechanical and biological properties of calcium phosphate cement (CPC, nanometer-biomaterial) for bone reconstruction in the rabbit femoral defect model, fibrin glue (FG, the natural product, purified from the blood) was introduced at three different ratios. The CPC powder and the FG solution were mixed, respectively, at the powder/liquid (P/L) ratios (g/mL) of 1:1, 3:1, and 5:1 (g/mL), and pure CPC was used as a control. After being implanted into the femoral defect in rabbit, the healing process was evaluated by micro-computed tomography scan, biomechanical testing, and histological examination. By micro-computed tomography analysis, the P/L ratio of 1:1 (g/mL) group indicated the largest quantity of new bone formation at 4 weeks, 8 weeks, and 12 weeks after implantation, respectively. Bone volume per trabecular volume of the 1:1 group was highest in the four groups, which was 1.45% ± 0.42%, 7.35% ± 1.45%, and 29.10% ± 1.67% at 4 weeks, 8 weeks, and 12 weeks after the operation, respectively. In the biomechanical tests, the compressive strength and the elastic modulus of the three CPC-FG groups were much higher than those of the pure CPC group at the determined time point (P , 0.05). The histological evaluation also showed the best osseointegration in the 1:1 group at 4 weeks, 8 weeks, and 12 weeks after the operation, respectively. In the 1:1 group, the bone grew into the pore of the cement in the laminar arrangement and connected with the cement tightly at the 12th week after the operation. This present study indicated that the CPC-FG composite at the P/L ratio of 1:1 (g/mL) stimulated bone regeneration better than any other designed group, which suggested that CPC-FG at the P/L ratio of 1:1 has significant potential as the bioactive material for the treatment of bone defects.

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Section: Discussionmentioning

confidence: 54%

The mechanical and biological studies of calcium phosphate cement-fibrin glue for bone reconstruction of rabbit femoral defects

Dong¹,

Geng²,

Bi³

et al. 2013

IJN

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“…For example, β-TCP powder and granules have been used to obtain a so-called brushite cement (Ohura et al, 1996), whereas hydroxyapatite powder is often used in the composition of apatite cements to accelerate the setting reaction (Chow, 1996). Furthermore, additives such as citrate ions , and xanthan (Lu et al, 1999) have been described in combination with calcium phosphate cements.…”

Section: Discussionmentioning

confidence: 99%

Theoretical and experimental approach to test the cohesion of calcium phosphate pastes

Bohner

Doebelin²,

Baroud³

2006

eCM

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Recent studies have revealed that the ability of a calcium phosphate cement paste to harden in a physiological environment without desintegrating into small particles might be a key property to ensure a safe and reliable clinical use of calcium phosphate cements. However, this property called cohesion is not well understood and has not been studied extensively. The goal of the present study was to better understand which factors affect the cohesion of a calcium phosphate paste using the combination of a theoretical and experimental approach. In the theoretical approach, factors expected to influence the paste cohesion such as Van der Waals forces, electrostatic and steric interactions, as well as osmotic effects were listed and discussed. In the experimental approach, a new method to measure the cohesion of a non-setting calcium phosphate paste was presented and used to assess the effects of various factors on this property. The new method allowed a continuous measurement of cohesion and gave reproducible results. The experimental results confirmed the theoretical predictions: an increase of the liquid-to-powder ratio of the paste and of the powder particle size, as well as the addition of citrate ions and in limited cases dissolved xanthan polymer chains reduced the paste cohesion.

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“…However, some studies demonstrated that tunneling combined with screw or membrane mediated stabilization of the grafts can be a predictable vertical augmentation technique [153,154,155,156,158,159,160,161,162,163,165,166,167]. Calcium phosphate based biomaterials such as brushite cement pastes have been evaluated in various in vivo studies as injectable pastes with controlled viscosity and additives to achieve minimally invasive vertical bone augmentation [168,169,170,171,172,173,174,175,176,177]. …”

Section: Techniques For Vertical Bone Augmentationmentioning

confidence: 99%

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Sima²,

2015

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Alveolar bone augmentation in vertical dimension remains the holy grail of periodontal tissue engineering. Successful dental implant placement for restoration of edentulous sites depends on the quality and quantity of alveolar bone available in all spatial dimensions. There are several surgical techniques used alone or in combination with natural or synthetic graft materials to achieve vertical alveolar bone augmentation. While continuously improving surgical techniques combined with the use of auto- or allografts provide the most predictable clinical outcomes, their success often depends on the status of recipient tissues. The morbidity associated with donor sites for auto-grafts makes these techniques less appealing to both patients and clinicians. New developments in material sciences offer a range of synthetic replacements for natural grafts to address the shortcoming of a second surgical site and relatively high resorption rates. This narrative review focuses on existing techniques, natural tissues and synthetic biomaterials commonly used to achieve vertical bone height gain in order to successfully restore edentulous ridges with implant-supported prostheses.

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Histological and biomechanical studies of two bone colonizable cements in rabbits

Cited by 24 publications

References 17 publications

The mechanical and biological studies of calcium phosphate cement-fibrin glue for bone reconstruction of rabbit femoral defects

The mechanical and biological studies of calcium phosphate cement-fibrin glue for bone reconstruction of rabbit femoral defects

Theoretical and experimental approach to test the cohesion of calcium phosphate pastes

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

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