Histological and histochemical studies of the nipples of estrogen treated guinea pigs with special reference to keratohyalin granules

Lansing, Albert I.; Opdyke, D.L.J.

doi:10.1002/ar.1091070405

Cited by 19 publications

References 24 publications

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The influence of vitamin A on the epidermis

et al. 1955

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TWELVE FIQURESSabella, Bern and Kahn ( '51) demonstrated that vitamin A dissolved in sesame oil, applied topically to the dorsal epidermis of castrated mature feimale rats f o r 10 days, resulted in a significant increase in thickness of the whole epidermis (less the stratum corneum) and of the stratum granulosum alone over both that of sesame oil-treated and of untreated controls. Effects on the stratum corneum were indicated, including occasional parakeratosis, but were not possible to quantify. It was concluded that topical vitamin A application resulted in acanthosis and that there was some evidence for interference with the normal keratinization process. Estrogen did not affect the epidermal picture when topically administered alone for the same period of time, nor did it alter the response to vitamin A when administered silmultaneously with the latter.These results are similar t o those obtained by Swiss investigators (Studer and Frey, '49, '52; Studer, '53) who administered large quantities of the vitamin orally and topically to very young rats. However, they ('49) reported a maximal effect after 11-13 days of oral treatment and a regression to the normal thickness, despite continuation of treatment, after an additional 10 days. I n addition to these studies, vitamin A has been shown to interfere with estrogen-induced vaginal '

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