Histological and molecular classification of gastrointestinal polyps

Haumaier, Franziska; Sterlacci, William

doi:10.1016/j.bpg.2017.06.005

Cited by 12 publications

(5 citation statements)

References 68 publications

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“…During the study period (2016-2017) the 2010 WHO criteria were more stringent and required at least three affected crypts [30]. A number of authors had highlighted that these older criteria were not clear-cut and the prerequisite of at least three affected crypts might not be practical [31]. Prior to the 2019 WHO edition, there was no uniformity as to which criteria were used at our centre to diagnose SSLs, with some opting for the less stringent Expert Panel recommendations, and others, the 2010 WHO [32].…”

Section: Discussionmentioning

confidence: 99%

“…Reported rates of reclassification in the literature range from 2.6-85%, in studies from 2007 to 2019 [4,11,19,24,25,[33][34][35][36][37][38][39][40]. The wide range is mostly attributable to the multiple diagnostic criteria with different levels of stringency that characterised earlier years [4,7,23,31]. Of the aforementioned studies, only Bettington et al, and Janjua et al relied solely on the WHO criteria (2010), whilst Gill et al, and Khalid et al used a combination of criteria that included reference to the WHO [23][24][25]37].…”

Section: Diagnostic Criteriamentioning

confidence: 99%

“…Although current criteria are less stringent, it still appears that SSLs remain underdiagnosed [5,13,23]. The application of different diagnostic criteria is a well-recognised source of interobserver variability [5,23,31,41]. The strict, uniform application of consensus criteria however, improves diagnostic reproducibility of SSLs [1,42].…”

Section: Diagnostic Criteriamentioning

confidence: 99%

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Hyperplastic polyp or sessile serrated lesion? The contribution of serial sections to reclassification

Jaravaza

Rigby

2020

Diagn Pathol

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Background The histological discrimination of hyperplastic polyps from sessile serrated lesions can be difficult. Sessile serrated lesions and hyperplastic polyps are types of serrated polyps which confer different malignancy risks, and surveillance intervals, and are sometimes difficult to discriminate. Our aim was to reclassify previously diagnosed hyperplastic polyps as sessile serrated lesions or confirmed hyperplastic polyps, using additional serial sections. Methods Clinicopathological data for all colorectal hyperplastic polyps diagnosed in 2016 and 2017 was collected. The slides were reviewed and classified as hyperplastic polyps, sessile serrated lesion, or other, using current World Health Organization criteria. Eight additional serial sections were performed for the confirmed hyperplastic polyp group and reviewed. Results Of an initial 147 hyperplastic polyps from 93 patients, 9 (6.1%) were classified as sessile serrated lesions, 103 as hyperplastic polyps, and 35 as other. Of the 103 confirmed hyperplastic polyps, 7 (6.8%) were proximal, and 8 (7.8%) had a largest fragment size of ≥5 mm and < 10 mm. After 8 additional serial sections, 11 (10.7%) were reclassified as sessile serrated lesions. They were all less than 5 mm and represented 14.3% of proximal polyps and 10.4% of distal polyps. An average of 3.6 serial sections were required for a change in diagnosis. Conclusion Histopathological distinction between hyperplastic polyps and sessile serrated lesions remains a challenge. This study has uncovered a potential role for the use of additional serial sections in the morphological reappraisal of small hyperplastic polyps, especially when proximally located.

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Section: Discussionmentioning

confidence: 99%

Section: Diagnostic Criteriamentioning

confidence: 99%

Section: Diagnostic Criteriamentioning

confidence: 99%

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Hyperplastic polyp or sessile serrated lesion? The contribution of serial sections to reclassification

Jaravaza

Rigby

2020

Diagn Pathol

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“…Los pólipos menores de 10 mm se resecaron durante la colonoscopia y los mayores de 10 mm, fueron programados en otra sesión para polipectomía, de manera ambulatoria, siguiendo el proceso administrativo de nuestra institución, que incluye solicitar hemograma y pruebas de coagulación. Histológicamente los pólipos fueron clasificados como: hiperplásicos, adenomatosos y serrados (26) . Así mismo, se consignó el porcentaje de pólipos en cada grupo y el porcentaje de pólipos adenomatosos (ADR: adenoma, detection, rate).…”

Section: Polipectomíasunclassified

Prevalencia comparativa de pólipos adenomatosos en personas de 45 a 49 años y en mayores de 50 años en una población colombiana: estudio de casos y controles

Cano¹,

Otero²,

Gómez³

et al. 2021

Rev Gastroenterol Peru

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Introducción: El cáncer de colon y recto (CCR) es el tercer cáncer más frecuente y la cuarta causa de muerte por cáncer en el mundo. En Colombia, es la tercera causa de muerte por cáncer. La recomendación más aceptada es hacer tamización con colonoscopia en personas de 50 a 75 años. Sin embargo, recientemente la Asociación Americana de Cáncer (ACS) ha recomendado iniciar la tamización a partir de los 45 años. En nuestro medio no hay estudios sobre prevalencia de pólipos adenomatosos en menores de 50 años. Objetivo: Comparar la prevalencia de pólipos adenomatosos durante colonoscopia de tamización en personas de 45-49 años (casos) y compararla con la de personas de 50 a 75 años (control). Materiales y métodos: Estudios de casos y controles. Los datos se recolectaron de forma prospectiva durante el periodo de enero 2018 hasta noviembre de 2019 en el centro de gastroenterología y endoscopia digestiva de Bogotá Colombia. Resultados: Se incluyeron 490 pacientes, 119 casos y 371 controles, relación casos:control fue 1:3. La prevalencia de pólipos en los casos 36,7% y en los controles (42,5%) p=0,279. Los pólipos adenomatosos se detectaron en 18,5% (IC 95% 12,4-26,6) de los casos y 32,4% (IC 95% 27,7-37,2) de los controles (p=0,004). Conclusión: La prevalencia de pólipos durante la colonoscopia de os es similar a la esperada en colonoscopias de tamización de personas entre los 50-75 os. Este hallazgo favorecería colonoscopia de tamización a partir de los 45 años.

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“…Colorectal cancer is the third most common cancer and the fifth leading cause of cancer-related deaths worldwide [ 1 ]. Colorectal polyps, especially adenomatous polyps, are considered pre-cancerous lesions caused by numerous factors such as smoking, age, and excessive red meat intake [ 2 ]. Colonoscopy is the gold standard for detecting pre-cancerous lesions such as colorectal polyps.…”

Section: Introductionmentioning

confidence: 99%

Atrophic gastritis rather than Helicobacter pylori infection can be an independent risk factor of colorectal polyps: a retrospective study in China

Shao-hua,

Lin-lin,

Shen

et al. 2023

BMC Gastroenterol

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Background Colonoscopy is considered the most effective screening method for colorectal polyps. However, the longevity and complexity of the procedure makes it less desirable to screen for colorectal polyps in the general population. Therefore, it is essential to identify other independent risk factors. In this study, we explored the link between Hp infection, atrophic gastritis, and colorectal polyps to identify a new potential risk factors of colorectal polyps. Methods In this study, atrophic gastritis and intestinal polyps were diagnosed by endoscopy and pathology. All the 792 patients in this retrospective study were divided into sub-groups based on the presence of colorectal polyps. The correlation between polyps and atrophic gastritis was analyzed using the chi-square test and Kruskal-Wallis test. The receiver operating characteristic (ROC) curve was used to compare the predictive value for colorectal polyps between Hp infection and atrophic gastritis. Binary logistic regression was utilized to identify independent risk factors for colorectal polyps. Results Patients with colorectal polyps were primarily male with advanced age, and the number of patients with colorectal polyps had a higher association with smoking, alcohol drinking, and Hp infection than the control group. A positive correlation between the number of colorectal polyps and the severity of atrophic gastritis was observed. ROC analysis showed that atrophic gastritis was a better risk factors for colorectal polyps. Multivariate analysis identified atrophic gastritis as an independent risk factor for colorectal polyps (OR 2.294; 95% CI 1.597–3.296). Conclusions Atrophic gastritis confirmed could be an independent risk factors for colorectal polyps.

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Histological and molecular classification of gastrointestinal polyps

Cited by 12 publications

References 68 publications

Hyperplastic polyp or sessile serrated lesion? The contribution of serial sections to reclassification

Hyperplastic polyp or sessile serrated lesion? The contribution of serial sections to reclassification

Prevalencia comparativa de pólipos adenomatosos en personas de 45 a 49 años y en mayores de 50 años en una población colombiana: estudio de casos y controles

Atrophic gastritis rather than Helicobacter pylori infection can be an independent risk factor of colorectal polyps: a retrospective study in China

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