Histological changes in the organs of rats injected with œstrone alone or simultaneously with æstrone and testicular hormone

Korenchevsky, V.; Dennison, Marjorie

doi:10.1002/path.1700410214

Cited by 78 publications

(13 citation statements)

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“…When the pathological changes due to injections of estrogen had been established, Rusch (16) found that adequate doses of androgen caused a reversal of the epithelial changes although the increase of stroma was not reduced. In the rat, male hormone administered with estrone completely prevented the pathological changes in the prostate (32). In the monkey swelling of the sexual skin and metaplasia in the prostate were suppressed by simultaneous injections of male hormone (33,34,36).…”

Section: Spontaneous Prostatic Enlargement In the Dog--this Conditiomentioning

confidence: 95%

“…Korenchevsky and Dennison (14) reported that the prostate glands of rats similarly treated were much smaller than those of control rats, although they were larger than the glands of castrated rats. They found that changes in the ventral and lateral lobes were slight, while in the posterior lobes significant epithelial metaplasia and connective tissue hypertrophy developed (32). Selye (15) found that estradiol produced a decrease in weight of the prostate glands as compared with uninjected controls.…”

Section: Spontaneous Prostatic Enlargement In the Dog--this Conditiomentioning

confidence: 99%

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Quantitative Studies of Prostatic Secretion

Huggins

Clark

1940

Journal of Experimental Medicine

333

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Benign enlargement of the prostate, a lesion wherein localized overgrowth of an organ develops in old age, occurs in senile dogs and in no other species commonly used in the laboratory (1, 2). The high incidence of this spontaneous disease facilitated the present investigation of a condition which often involves the prostate gland of old men.No quantitative experimental studies of prostatic enlargement in the dog have been reported previously. The production of shrinkage of the hypertrophied gland was studied and in this paper the effects of castration and of injections of estrogenic and of androgenic materials are described as well as observational data on the enlarged canine prostate. For the purpose of experimental control estrogen was also injected in immature, castrate, and normal adult dogs.The approach consisted in assay of the pathological status before and after hormonal modifications and frequent testing of prostatic secretion throughout the period of experimentation. Spontaneous Prostatic Enlargement in the Dog.--This condition is not seen in dogs lessthan 4 years of age and does not produce urinary obstruction (3). While an appreciable growth of the prostate gland occurs after sexual maturity (4), in the pathological state the gland becomes greatly hypertrophied and can weigh at least 160 grn. as compared with 10 gm. or less in normal adult dogs (5); in all dogs in which the prostate weighed more than 0.7 gm. for each kilo of body weight, the gland was abnormal histologically (5). The enlargement is due to a hyperplasia of epithelium with marked papillary ingrowth and dilatation of the alveoli to form cysts containing clear fluid (6,7,46). In many cysts the lining epithelium varies from tall columnar to fiat epithelium in the same dilated alveolus although in some cysts all of the epithelium is flat (7). Spermatogenesis is in progress in most of the dogs (4) and many of them have tumors of the testis (4,6,7,35).

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Section: Spontaneous Prostatic Enlargement In the Dog--this Conditiomentioning

confidence: 95%

Section: Spontaneous Prostatic Enlargement In the Dog--this Conditiomentioning

confidence: 99%

Quantitative Studies of Prostatic Secretion

Huggins

Clark

1940

Journal of Experimental Medicine

333

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“…From the Pharmacology Department, University of Edinburgh (Received 17 July 1957) For more than twenty years it has been known that female sex hormones and some of their synthetic substitutes produce adrenal hypertrophy when administered to rats (Korenchevsky & Dennison, 1935;Selye, Couip & Thomsen, 1935; Noble, 1939;and others). This hypertrophy is accompanied by a diminution of the lipid content (Loeser, 1939;Vogt, 1945).…”

Section: By Margarethe Holzbauermentioning

confidence: 99%

The effect of oestrogens on the secretory capacity of the rat adrenal cortex in vivo

Holzbauer¹

1957

The Journal of Physiology

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Inhibition by hexoestrol of adrenocortical secretion in the rat

Vogt¹

1955

The Journal of Physiology

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It has been known for a long time (Korenchevsky & Dennison, 1935; Selye, Collp & Thomsen, 1935) that oestrogens cause hypertrophy and hyperplasia of the rat adrenal cortex. Selye & Collip (1936) have shown that this effect is absent in the hypophysectomized rat, even when the adrenal cortex is maintained by adrenocorticotrophic hormone (ACTH). The inference is that oestrogens cause an increase in secretion of ACTH and thus produce adrenal hypertrophy indirectly. During hexoestrol administration the pituitary hypertrophies and goes on growing for at least 6 weeks (Somers, 1948). Gemzell (1952) was able to demonstrate an increase in the amount of circulating ACTH in rats injected with oestradiol. The release of ACTH by oestrogens is considered to be an example of an unspecific response to stress (Tepperman, Engel & Long, 1943). Loeser (1939) observed the disappearance of lipids from the adrenals of rats injected with stilboestrol. A detailed examination of the effect of hexoestrol (Vogt, 1945) showed that sudanophilic lipids disappeared almost completely from the zonae fasciculata and reticularis in the course of 5 days, and from all three layers if the treatment lasted 10 days or more. These effects, too, were absent in hypophysectomized rats not given ACTH: experiments with ACTHmaintained rats were not performed.The functional state of lipid-depleted adrenals has been a matter of conjecture. Many histologists consider them to be hyperactive glands (Dosne & Dalton, 1941;Sarason, 1943), whereas others (Zwemer, 1936;Deane & McKibbin, 1946; Flexner & Groilman, 1939) suggest that they are in a state of exhaustion following initial hyperactivity. Both these interpretations are prompted by the observation that the early response to any stress or to an injection of ACTH is a diminution of adrenal lipids, more especially of cholesterol esters. However, this diminution is followed by recovery to normal or even by deposition of abnormally high amounts of lipids whenever treatment

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Histological changes in the organs of rats injected with œstrone alone or simultaneously with æstrone and testicular hormone

Cited by 78 publications

References 9 publications

Quantitative Studies of Prostatic Secretion

Quantitative Studies of Prostatic Secretion

The effect of oestrogens on the secretory capacity of the rat adrenal cortex in vivo

Inhibition by hexoestrol of adrenocortical secretion in the rat

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