The effect of oestrogens on the secretory capacity of the rat adrenal cortex <i>in vivo</i>

Holzbauer, Margarethe

doi:10.1113/jphysiol.1957.sp005892

Cited by 18 publications

(6 citation statements)

References 14 publications

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“…The present data with the unstressed oestrogen-treated rat confirmed this observation, but after a stress the concentration of corticosterone in the gland increased whereas the secretion rate was decreased. A similar phenomenon was demonstrated by Pincus & Hirai (1964) (Holzbauer, 1957b). Other experiments suggested strongly that this was the case (Boyd & McGuire, 1956;Holzbauer & Vogt, 1957a (Holzbauer & Vogt, 1957b;Goodman, 1965).…”

Section: Discussionsupporting

confidence: 61%

“…However, Fukui, Takeuchi, Watanabe, Kumagai, Yano & Nishino (1961) found that oestradiol added to adrenal glands in vitro stimulated corticosterone production, suggesting a direct action on the adrenal cortex. Other workers have demonstrated increased adrenal gland corticosterone concentrations after in vivo oestrogen treatment (Holzbauer, 1957b;Llaurado, Claus & Trunnell, 1962;Cushman, Pulido & Hilton, 1965). Holzbauer (1957b) observed that stimulation occurred only with low initial ACTH levels and that with high circulating ACTH there was an inhibition of corticosterone secretion.…”

Section: Discussionmentioning

confidence: 99%

“…Other workers have demonstrated increased adrenal gland corticosterone concentrations after in vivo oestrogen treatment (Holzbauer, 1957b;Llaurado, Claus & Trunnell, 1962;Cushman, Pulido & Hilton, 1965). Holzbauer (1957b) observed that stimulation occurred only with low initial ACTH levels and that with high circulating ACTH there was an inhibition of corticosterone secretion. These observations have been confirmed in the present paper when single doses of ethinyloestradiol were used.…”

Section: Discussionmentioning

confidence: 99%

“…There have been many reports demonstrating that oestrogens can inhibit corticosterone secretion, and in most cases the experimental procedures applied were known to cause near maximal secretion of ACTH (Vogt, 1955;Holzbauer, 1957b;Holzbauer & Vogt, 1957a ;Kitay, 1963b;Saba & Hoet, 1963 ;Pincus & Hirai, 1964).…”

Section: Discussionmentioning

confidence: 99%

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The actions of ethinyloestradiol on the pituitary‐adrenal system of the rat

1970

British J Pharmacology

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Summary1. Single doses of ethinyloestradiol stimulate the pituitary adrenal axis of the female rat during quiescent conditions. 2. After a stimulus which releases endogenous ACTH, there is an inhibition of the release of corticosterone from the adrenal gland, but an increase in the corticosterone stored in the gland.3. Ethinyloestradiol (1V0 mg/kg) injected acutely or daily for 7 days does not affect the corticosterone bindinlg capacity of plasma in female rats, or the clearance rate of an injection of corticosterone. 4. Prolonged treatment with ethinyloestradiol and ACTH inhibits the pituitary-adrenal response to a stress and to an ACTH injection, indicating a block at the adrenal and pituitary level. 5. The adrenal gland recovers more rapidly than the pituitary after cessation of the oestrogen treatment. 6. The inhibition of the pituitary-adrenal response to stress after oestrogen is probably caused by inhibition of cholesterol synthesis as suggested by others. Oestrogens can increase corticoid secretion during non-stress conditions, however, so precursor lack through exhaustion cannot be excluded. 7. It is suggested that the inhibition of the stress response after prolonged ACTH treatment is due to a decrease in sensitivity of the adrenal cortex after frequent ACTH stimulation, but the possibility that it is due to a reduction in circulating cholesterol cannot be ruled out.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The actions of ethinyloestradiol on the pituitary‐adrenal system of the rat

1970

British J Pharmacology

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“…From the present experimental results it appears that corticosterone, an established feedback regulator of adrenocorticotrophic hormone (ACTH), prevents the testicular degeneration and the failure of a2u-globulin synthesis which usually result from oestrogen treatment in the adult male rats. As adrenalectomy can cause a reduction in oc2u-globulin synthesis, the effect of oestrogen may be achieved by an inhibition of adrenocortical function which has been reported by Vogt (1955), Holzbauer (1957), McKerns & Bell (1960) and Sanyal, Patra & Biswas (1978). However, adrenal hypertrophy has been reported in oestrogen-treated rats, but this may result from increased ACTH secretion in response to the blockage of synthesis of adrenal corticosterone (Colby & Kitay, 1974).…”

Section: Resultsmentioning

confidence: 88%

EFFECT OF CORTICOSTERONE ON SERUM CONCENTRATIONS OF α2u-GLOBULIN AND ON SPERMATOGENESIS IN OESTROGEN-TREATED RATS

Biswas¹,

Ghosh²,

Neuhaus³

1982

Journal of Endocrinology

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Treatment of adult male rats with oestradiol-17 beta (50 microgram/100 g body wt per day for 7 days) resulted 14 days later in reduced levels of alpha 2 micro-globulin in serum and inhibition of spermatogenesis. Administration of corticosterone (2 mg/day) for 14 days to oestrogen-treated rats raised the concentration of alpha 2 micro-globulin in the serum and prevented spermatogenic degeneration. It is concluded that endogenous alpha 2 micro-globulin induced by corticosterone may play a role in spermatogenesis in oestrogenized rats.

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