Histological effect of rifampicin drug in the kidney and liver of tissue of albino mice Mus Musclus

Abstract

The aim of this study is to investigate the histopathological changes induced by the anti-tuberculosis durg (rifampicin) in the tissues of the kidneys and liver of white male mice of Mus Musculus. 25 mice were distributed into five groups that included a control group, a therapeutic dose group of 1.25 mg, and a toxic dose group of 2.5 mg. The semi-lethal LD dose group was 150 mg, and the lethal LD dose group was 240 mg.
 The results also showed behavioral changes for the treated animals, the intensity of which increased with the increase in concentrations, and the total of these changes was represented by eating less food and drinking water, lack of movement, diarrhea, rapid breathing, and red-orange urine, and these symptoms were more severe in the fatal group and ended with the animal's death.
 In the kidneys, the tissue lesions were represented by the occurrence of necrosis in the cells of the urinary tubules in some areas, the infiltration inflammatory cells clearly, the degeneration of some cells of the urinary tubules, and the swelling of a part of the cells, which led to a narrowing in the lumen of the urinary tubules. The nuclei are necrotic and disintegrated. The glomerulus was some areas enlarged and some areas atrophic. Also, fibrosis of the kidney tissue was observed, which increases with increasing dose.
 In the liver, it was represented by the occurrence of necrosis, hemorrhage and congestion, infiltration inflammatory cell thickening of the plasma membrane, widening of the sinusoids some areas and narrowing them at other areas the onset of fibrosis, kuffper cells.
 Conclusion: The administration of rifampicin led to pathological changes in the kidneys, represented by necrosis, glomerulosclerosis and fibrosis, as well as pathological changes in the liver represented by rupture of the vessel wall, nuclei enlargement and hemorrhage.