Histological effects of gold nanoparticles on the lung tissue of adult male albino rats

Elbakary, Reda H.; Okasha, Ebtsam F.; Ragab, A. M.; Ragab, Mohamed Hassan

doi:10.4103/jmau.jmau_25_18

Cited by 12 publications

(14 citation statements)

References 31 publications

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“…the ingestion by licking of particles that accumulate on the skin and the fur. In this context, it is interesting to note that, in a study on the effect of orally administered 10-20 nm AuNPs on the histological structure of the rat lung tissue, pulmonary damage was observed (Elbakary et al 2018). In this research, adult male albino rats were divided into three groups: two groups treated with AuNPs (one receiving a low dose and another one receiving a high dose every day) and a control group.…”

Section: Sung Et Al (2011)mentioning

confidence: 98%

“…On the other hand, the whole-body inhalation system involves other types of exposure such as, in particular, ingestion. As it has been shown that oral administration can cause lung damage (Elbakary et al 2018), also the exposure by whole-body inhalation chamber is not ideal as it may lead to an overestimation of the damage. The main limitations of in vivo studies are therefore due to the lack of an appropriate model of exposure.…”

Section: Sung Et Al (2011)mentioning

confidence: 99%

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Exposure to airborne gold nanoparticles: a review of current toxicological data on the respiratory tract

Berardis¹,

Marchetti²,

Risuglia

et al. 2020

J Nanopart Res

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In recent years, the introduction of innovative low-cost and large-scale processes for the synthesis of engineered nanoparticles with at least one dimension less than 100 nm has led to countless useful and extensive applications. In this context, gold nanoparticles stimulated a growing interest, due to their peculiar characteristics such as ease of synthesis, chemical stability and optical properties. This stirred the development of numerous applications especially in the biomedical field. Exposure of manufacturers and consumers to industrial products containing nanoparticles poses a potential risk to human health and the environment. Despite this, the precise mechanisms of nanomaterial toxicity have not yet been fully elucidated. It is well known that the three main routes of exposure to nanomaterials are by inhalation, ingestion and through the skin, with inhalation being the most common route of exposure to NPs in the workplace. To provide a complete picture of the impact of inhaled gold nanoparticles on human health, in this article, we review the current knowledge about the physico-chemical characteristics of this nanomaterial, in the size range of 1–100 nm, and its toxicity for pulmonary structures both in vitro and in vivo. Studies comparing the toxic effect of NPs larger than 100 nm (up to 250 nm) are also discussed.

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Section: Sung Et Al (2011)mentioning

confidence: 98%

Section: Sung Et Al (2011)mentioning

confidence: 99%

Exposure to airborne gold nanoparticles: a review of current toxicological data on the respiratory tract

Berardis¹,

Marchetti²,

Risuglia

et al. 2020

J Nanopart Res

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“…Although the excretion route of the gold nanomaterials will also depend on their size and shape, there is some agreement that the use of particles between 10 and 100 nm slows down the activation of the mononuclear phagocyte system, while still being large enough to avoid immediate renal filtration [44][45][46]. It should be noted that in contrast with the study of Elbakary et al [27], these investigations indicate very little or no toxicity, reflecting the more realistic doses employed.…”

Section: Toxicology and Organ Distributionmentioning

confidence: 84%

“…However, there is a degree of consensus regarding the role of positive surface charge in the induction of ROS and pro-inflammatory mediators [ 26 ]. A study by Elbakary et al [ 27 ] indicated the occurrence of lung remodelling after intratracheal instillation of gold nanoparticles in healthy adult male rats, exhibiting congestion of blood vessels, alveolar collapse, extravasation of red blood cells and thickening in the alveolar wall, suggesting fibrosis. However, the rats were exposed to 40 or 400 µg/kg of the nanomaterial every day for 14 days — doses which might be expected to induce pulmonary inflammation independent of any innate particle toxicity.…”

Section: Lc and Gold Nanomaterialsmentioning

confidence: 99%

Gold nanomaterials in the management of lung cancer

Perry

Wilton‐Ely

Tetley

2020

Emerging Topics in Life Sciences

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Lung cancer (LC) is one of the most deadly cancers worldwide, with very low survival rates, mainly due to poor management, which has barely changed in recent years. Nanomedicines, especially gold nanomaterials, with their unique and size-dependent properties offer a potential solution to many challenges in the field. The versatility afforded by the shape, size, charge and surface chemistry of gold nanostructures allows them to be adapted for many applications in the diagnosis, treatment and imaging of LC. In this review, a survey of the most recent advances in the field is presented with an emphasis on the optical properties of gold nanoscale materials and their use in cancer management. Gold nanoparticle toxicology has also been a focus of interest for many years but the studies have also sometimes arrived at contradictory conclusions. To enable extrapolation and facilitate the development of medicines based on gold nanomaterials, it must be assumed that each design will have its own unique characteristics that require evaluation before translation to the clinic. Advances in the understanding and recognition of the molecular signatures of LC have aided the development of personalised medicines. Tailoring the treatment to each case should, ideally increase the survival outcomes as well as reduce medical costs. This review seeks to present the potential of gold nanomaterials in LC management and to provide a unified view, which will be of interest to those in the field as well as researchers considering entering this highly important area of research.

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“…From this point, gold is the most suitable metal for nanotechnology. One of the most affected organs for local and systemic drug delivery is the lung because of its large surface area and close contact with the blood circulation [3]. A comparative evaluation of the biodistribution and the toxic profiles of GNPs and SilverNano Particles (SNPs) showed that their chemical composition played a critical role in their in vivo biodistribution and toxicity.…”

Section: Introductionmentioning

confidence: 99%

Hematobiocemical and Histopathological Studies on the Effects of Raj Nirwan Bati (A Novel Allovedic Drug) in Wistar Rats

Singh

Kumar

Kannaujia

et al. 2022

Int J Pharm Pharm Sci

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Objective: To see the effects of Raj Nirwan Bati (RNB) on the hematobiochemical parameters, coagulation tests, and histopathological changes in the lungs, liver, kidneys and spleen and also to evaluate the immunomodulatory activity of RNB in Wistar rats. Methods: A total of 24 adult albino Wistar rats (of bodyweight 200-250 g) of either sex were divided into 3 groups. In the normal control group (n=8), no drug was administered and in the rest of the groups (A and B), RNB@ 26 mg/kg body weight./day and 260 mg/kg body weight/day respectively were administered orally for a period of 14 d. The blood samples were collected from the jugular vein at zero d (before drug administration) and after the 14th d of drug administration in both groups (A and B). The organ samples (lungs, liver, kidneys, and spleen) were collected after euthanizing the rats using Ketamine anesthesia overdose intraperitoneally (IP) after the 14th d of drug administration. White Blood Cells (WBC), Red Blood Cells (RBC), Hemoglobin (Hb), Hematocrit (HCT), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin(MCH), Mean Corpuscular Hemoglobin Concentration(MCHC), number of platelets, Differential Leucocyte Count(DLC) i.e. the percentage of neutrophils, lymphocytes, eosinophils, monocytes and basophils, neutrophil adhesion percentage, Prothrombin test (PT), Activated Partial Thromboplastin Time (APTT), fibrinogen, D-dimer, Lactate Dehydrogenase (LDH), urea, creatinine, Aspartate Amino Transferase (AST), Alanine amino Transferase (ALT), Alkaline Phosphatase (ALP), C-Reactive Protein (CRP) were evaluated and histological examination of organs were done. Results: After statistical analysis, it was found that the decrease in TLC, RBC, Hb, HCT, and LDH in Wistar rats after RNB intervention in Group A as compared to that of before RNB intervention, was found to be statistically significant (P=0.001, P=0.002, P=0.001, P=0.039, and P=0.008). On the other hand, an increase was observed in MCV, Urea, Creatinine and ALT values in the Wistar rats after RNB intervention in Group ‘A’ as compared to that of before RNB intervention and this increase in values was statistically significant (P=0.007, P=0.001, P<0.001 and P=0.038). After RNB intervention in Group B, the increase in MCH, fibrinogen concentration, and monocytes percentage, was found to be statistically significant (P=0.004, P=0.033, and P=0.001) as well as the decrease in PT and APTT was statistically significant (P=0.007and P=0.002). After comparing the Mean Hematobiochemical and coagulation test parameters in the rats of Group A and Group B, after RNB intervention, it was observed that the concentration of Urea, Creatinine, APTT, and D-dimer were less in Group B as compared to that of Group A and this difference was statistically significant (P<0.001, P<0.001, P<0.001 and P=0.022). Histologically the findings in the lungs of group B were more distortion of lung architecture, most of the alveoli become collapse and make emphysematous changes, more diffuse inflammatory infiltrate within interalveolar septa and around bronchioles as compared to Group A. In the liver of group B rats, the histological findings were mild to moderate distortion of lobular architecture, healthy hepatocytes with more activation of kupffer cells as well as larger and more aggregates of inflammatory cells as compared to group A. Histological findings of kidneys in group A and group B rats were similar to that of control group rats. Conclusion: The results suggest that the RNB is having an immunomodulatory effect. It might be helpful in the restoration of coagulation factors and can help treat the COVID patients. No harmful effects on the lungs, liver, kidney, and spleen were seen. These findings may act as baseline data for planning further clinical trials in human study subjects to evaluate the effects on various comorbidities.

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Histological effects of gold nanoparticles on the lung tissue of adult male albino rats

Cited by 12 publications

References 31 publications

Exposure to airborne gold nanoparticles: a review of current toxicological data on the respiratory tract

Exposure to airborne gold nanoparticles: a review of current toxicological data on the respiratory tract

Gold nanomaterials in the management of lung cancer

Hematobiocemical and Histopathological Studies on the Effects of Raj Nirwan Bati (A Novel Allovedic Drug) in Wistar Rats

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