Histological Evaluation of the Effects of Borax Obtained from Various Sources in Different Rat Organs

Abstract

SUMMARY:Boron is an essential element for life and intake via different sources into the body. Because effects of boron and compounds on the body has not been studied enough especially in tissue level, we planned this study to evaluate the effects of borax the most intaken form of boron compound on different intraabdominal organs histologically and also clinically. 42 male rats divided into equal 7 groups and different toxicological doses consistent with its LD50 dose (5000 mg/kg/d) were administered by gavage except control and sham groups. In the study, 2 different kinds of borax one of which was produced for research and the other for agriculture but the same formulation, were used and their effects were also compared. As a result it was found that borax did not cause any histological changes in kidney, large intestine, liver and stomach in lower doses. But if doses were increased, a slightly inflammatory cell migration was detected without clinical signs in liver and large intestine. However, when a single very high dose of borax was administered, very high edema, inflammatory cell migration and neovascularization was observed and clinically 2 out of 6 rats died within 5 hours. We suggested that very high dose intake of borax may cause sudden death and also during long periods and higher dose intake may pave the way of inflammatory bowel diseases. At the same time, in boron related studies we advice that the kind of boron and also their source should be evaluated carefully and the most suitable compound should be chosen in case of faulty results.

Mechanical activation and cement formation of trimagnesium phosphate

“…The results from this study will help to improve the applicability of MPC as bone replacement material since it enables the formation of single component cements without further additives, for example, ammonium ions or borax for adjusting setting times . Especially the latter is critical since borate ions may have a cytotoxic or even genotoxic effect in vivo at higher doses …”

Boraks Kullanimina Bağli Kan-Testi̇s Bari̇yeri̇nde Görülen Deği̇şi̇kli̇kleri̇n Hi̇stoloji̇k Değerlendi̇ri̇lmesi̇

“…Bununla birlikte daha önce ekibimiz tarafından yapılan geniş kapsamlı bir çalışmamızda aynı doz uygulaması yapılması ve aynı metodoloji uygulanması sonrasında mide, karaciğer, kalın barsaklar ve böbrekte boraks toksisitesi histolojik olarak araştırılmıştır. Bu çalışmada mide, karaciğer ve böbreklerde uygulanan her dozda herhangi bir histopatolojik değişiklik yokken sadece en yüksek dozda kalın barsaklarda inflamatuar hücre göçü olduğu ortaya konmuştur (21).…”

Penggunaan Bahan Tambahan Pangan Berbahaya (Boraks) Pada Bakso Tusuk Yang Dijual Di Sekolah Dasar Kecamatan Salo Kabupaten Kampar

“…Penggunaan boraks sangat berbahaya dan beracun sebagai bahan makanan, sehingga boraks sangat tidak diperbolehkan ada pada bahan baku pangan (Rahman,2019) Pada kejadian peningkatan dosis boraks dapat memicu terjadinya inflamasi sel, edema, neovaskularisasi, dan pada dosis yang sangat tinggi dapat menimbulkan terjadinya kematian mendadak (Kabu, 2015). Boraks dapat menimbulkan efek buruk dalam waktu yang lama, di dalam tubuh boraks akan tertimbun dan terakumulasi, kemudian menimbulkan efek samping seperti muntah, pusing, diare, mual,kejang hingga terjadi koma.…”