Histological Features of Human Papilloma Virus 16 and Its Association with the Development and Progression of Anal Squamous Cell Carcinoma

Kagawa, Ryuzaburo; Yamaguchi, Takahiro; Furuta, Reiko

doi:10.1007/s00595-006-3266-x

Cited by 8 publications

(10 citation statements)

References 17 publications

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“…Case series of invasive lesions have been included in Table 2.17 (available at http://monographs. iarc.fr/ENG/Monographs/vol100B/100B-06-Table2 .17.pd f ) (Kagawa et al, 2006;Varnai et al, 2006;Laytragoon-Lewin et al, 2007;Tachezy et al, 2007). All studies found high proportions of HPV in the tumours, predominantly HPV 16.…”

Section: (A) Case Seriesmentioning

confidence: 98%

A review of human carcinogens—Part B: biological agents

Bouvard

Baan

Straif

et al. 2009

The Lancet Oncology

2,513

1,958

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Section: (A) Case Seriesmentioning

confidence: 98%

A review of human carcinogens—Part B: biological agents

Bouvard

Baan

Straif

et al. 2009

The Lancet Oncology

2,513

1,958

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“…Detection of HPV DNA was performed by polymerase chain reaction (PCR) using SPF primers, 12 which amplify a fragment of 75 base pairs of the viral genome and developed to promote sensitive amplification of the most clinically relevant HPV genotypes. The assay is capable of detecting the genotypes currently known as high risk HPVs (16,18,26,31,33,35,39,45,51,52,53,56,58,59,66,68, 73 e 82), as well as low-risk HPV genotypes (6,11,40,43,44,54,70) and some additional types.…”

Section: Detection Of Hpv Genome In Tumor Samplesmentioning

confidence: 99%

Clinicopathological aspects and prevalence of human papillomavirus in anal cancer

Aguiar

Bosso

Leal

et al. 2014

Journal of Coloproctology

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Anal cancer is relatively rare; however, its incidence has increased in recent years. Several risk factors are associated with the development of anal cancer, including age older than 50 years, low-fiber diet, chronic anal fistulas, smoking, multiple partners, anal intercourse practice, Human Immunodeficiency Virus infection and immunosuppression. However, the presence of human papillomavirus represents the main risk factor for the development of anal cancer. The aim of this study was to evaluate the clinicopathological aspects of a series of patients with anal carcinomas diagnosed in Hospital Araújo Jorge, Goiânia-Goiás, as well as the prevalence of human papillomavirus genome in these tumors. Clinical, pathological and socio-demographic data were collected from the respective medical files and paraffin blocks containing anal carcinomas specimens were used for DNA extraction and detection of human papillomavirus, by means of polymerase chain reaction, using short PCR fragment primers. Forty-three cases were selected and had the data analyzed, while 38 cases were tested for human papillomavirus genome detection. Among the evaluated patients, 62.8% were women; 53.4% of tumors were squamous cell carcinoma and 46.5% of the patients were aged between 60 and 75 years. Risk factors, such as smoking (39.5%) and alcoholism (20.9%) were recorded in the studied group. Lymph node metastases were detected in 30.2% of cases and 7.0% had distant metastasis. The detection of human papillomavirus DNA was positive in 76% of cases assessed and this was significantly associated with squamous cell carcinomas. Aggressive behavior and advanced stage of anal cancer described in this study highlight the need for preventive measures that contemplate these tumors, including vaccination against human papillomavirus.

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“…Infection with oncogenic, or high-risk, HPV-16 was detected in all cases. Other studies also report that HPV-16 was the main HPV type found in over 80% of carcinomas [10,[16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of human papillomavirus infection in squamous cell carcinoma of the anal canal in a Northeast City in Brazil: viral genotyping and clinical aspects

et al. 2017

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Background: Anal cancer malignancies comprise about 1.5 to 3% of cancers from the gastrointestinal in which high-risk types of human papillomavirus (HR-HPV) is responsible for >80% of cases. The aim of this work was to detect and perform human papillomavirus (HPV) genotyping in squamous cell carcinoma specimens from the anal canal and to investigate the association between viral infection and histopathological and clinical aspects. Methods: The presence of genotype-specific HPV DNA in formalin-fixed paraffin embedded tissue from 27 anal SCC samples from a reference cancer hospital of São Luís, State of Maranhão, Brazil was performed by Linear Array HPV Genotyping Test and the INNO-LiPA HPV Genotyping Assay. Fisher's Exact test and Chi-square test were performed in order to evaluate the association between HPV type and clinical and morphological variables. P values less than 0.05 were considered statistically significant. Results: Average age of patients at the time of diagnosis was 54.96 years ± 15.81; 74.07% of patients were female. Vegetative ulcers represented the most common type of lesion (22.22%). The lesions ranged in size from 2.1 cm to 5.0 cm and mostly were well-differentiated (70.38%). Lymph node involvement was observed in 26% of the patients. Molecular evaluation revealed that HPV infection was detected in 81.48% of the lesions, and the most common type found was the oncogenic HPV 16. Statistical analysis indicated that the clinical and histopathological variables were not associated with HPV infection. Conclusions: Our results indicate that anal SCC rarely occurs in the absence of HPV and emphasize the predominant role of HPV16. The evaluation about genotype-specific prevalence of HPV in anal SCC is important to assess the potential benefit of HPV vaccination.

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Histological Features of Human Papilloma Virus 16 and Its Association with the Development and Progression of Anal Squamous Cell Carcinoma

Abstract: These findings show that HPV16 infection is closely involved in the development of anal SCC and suggest that the change in the genome occurs at the stage of microinvasive cancer.

Cited by 8 publications

References 17 publications

A review of human carcinogens—Part B: biological agents

A review of human carcinogens—Part B: biological agents

Clinicopathological aspects and prevalence of human papillomavirus in anal cancer

Prevalence of human papillomavirus infection in squamous cell carcinoma of the anal canal in a Northeast City in Brazil: viral genotyping and clinical aspects

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