Histological features of peripilar signs associated with androgenetic alopecia

Deloche, Claire; Lacharriére, Olivier de; Misciali, Cosimo; Piraccini, Bianca Maria; Vincenzi, Colombina; Bastien, Philippe; Tardy, Isabelle; Bernard, Bruno; Tosti, Antonella

doi:10.1007/s00403-003-0447-y

Cited by 114 publications

(93 citation statements)

References 17 publications

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“…This feature, called by some authors "hyperpigmentation" or "peripilar sign" is reflecting the presence of perifollicular lymphocytic infiltrates in early androgenic alopecia. 17 Our results confirm the presence of perifollicular discoloration also in healthy persons.…”

Section: Discussionsupporting

confidence: 84%

Trichoscopy (hair and scalp videodermoscopy) in the healthy female. Method standardization and norms for measurable parameters

Rakowska¹

2009

J Dermatol Case Rep

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Background: Trichoscopy is a newly developed method of hair image analysis, based on videodermoscopy of hair and scalp.Objective: The aim of the study was to establish normal values and set the standard for trichoscopy in female population.Patients and methods: A total of 60 healthy females with no symptoms of hair or scalp diseases in anamnesis, upon clinical examination and in classic hair diagnostic techniques were included into the study. Mean age of these females was 36.5 (19-64) years. Trichoscopy was performed with the use of Fotofinder II. In all patients trichoscopy was performed in four locations (frontal area, occipital area, left and right temporal area). Hair and perifollicular area were evaluated. Measurements were performed with the application of the MoleAnalyzer software.Results: Mean hair thickness was 0.061mm±0.008mm in frontal area vs. 0.057mm±0.007mm in occiput (p<0,001) and vs. 0.058mm ±0.008mm in left temporal area and 0.059mm±0.008mm in right temporal area (p>0.005). The percentage of thin hairs (below 0.03mm) was 5%±4.3 in frontal area vs. 5.5%±4.8 in occiput vs. 6.4%±5.7 in right temporal area. The highest proportion of single-hair pilosebaceous units was observed in the temporal areas (29.1±16.2 vs. 23.2±13.5 in frontal and 18.4±12.1 in occipital areas; p<0.005).Based on study results, the norms for parameters measured in trichoscopy were assessed: mean hair thickness bigger than 0,053mm in frontal area and bigger than 0,050mm in others; percentage of thin hairs should be less than 10% in frontal and occipital area and less than 13% in temporal areas.The percentage of pilosebaceous units with single hair should be less than 35% in frontal area, 30% in occiput and 40% in temporal areas.Yellow dots were seen sporadically and they shouldn't be in a higher number than 3 in 4 fields of vision with 70-fold magnification in frontal area and only 1 in others.Perifollicular discoloration should be lower than 25% for frontal area, lower than 15% in occiput and 20% for temporal areas.Conclusion: A standard procedure to perform trichoscopy (hair and scalp videodermoscopy) for diagnostic purposes was developed. Norms of measurable parameters were established for the population of adult white females.

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Section: Discussionsupporting

confidence: 84%

Trichoscopy (hair and scalp videodermoscopy) in the healthy female. Method standardization and norms for measurable parameters

Rakowska¹

2009

J Dermatol Case Rep

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“…On the other hand, female hair follicle appeared more active in prostaglandin synthesis than male one as shown by a significant difference (P < 0.01) with respect to mPGES-2 and AKR1C3 ⁄ PGFS gene expression. Considering the potential role of prostaglandins in hair growth and hair cycle control, one thus could speculate that such sexual difference might somehow be linked to the difference observed between males and females with regards to alopecia prevalence (23). Although the origin of these hair follicle sex-related differences remained unknown, it has however been reported that steroids could have, in some tissues, specific influence on prostaglandin level.…”

Section: Discussionmentioning

confidence: 99%

Prostaglandin metabolism in human hair follicle

Colombe

Vindrios

Michelet

et al. 2007

Experimental Dermatology

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Prostaglandins regulate a wide number of physiological functions. Recently PGF 2a analogue such as latanoprost was shown to have a real impact on hair regrowth. The aim of this study was to investigate and describe the expression profile in human hair follicle of prostaglandin metabolism key enzymes, i.e. carbonyl reductase-1 (CBR1), microsomal prostaglandin E synthase-1 (mPGES-1) and microsomal prostaglandin E synthase-2 (mPGES-2), cytosolic prostaglandin E synthase (cPGES), the aldoketoreductase AKR1C1 and the prostaglandin F synthase AKR1C3. Quantitative RT-PCR on plucked hair follicles revealed some sex-related differences, mPGES-2 and AKR1C3 expression levels being higher in women. Cell and hair follicle compartment specificity was investigated using Western blot, PGE 2 and PGF 2a ELISA assays and immunohistochemistry. Most of the hair cell types were endowed with prostaglandin metabolism machinery and were thus able to produce PGE 2 and ⁄ or PGF 2a . The epithelial part of the hair bulb was identified by immunohistology and EIA assays as the main source of prostaglandin synthesis and interconversion. All these observations support the concept that prostaglandins might be involved in hair growth and differentiation control.

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“…Ayrıca TE'de de gözlenebilir (6,7,11). Erken dönem AGA'da perifoliküler lenfositik infiltrat varlığıyla ilişkili olduğu gösterilmiştir (24). Ancak sağlıklı kişilerde de bu bulgu frontal bölgede %25 oranına varacak şekilde saptanabilir (8).…”

Section: Perifoliküler Epidermisunclassified

Trichoscopy

Dicle¹

2015

tdd

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Trikoskopi (saç ve saçlı deri dermoskopisi) klinikte sık görülen saç hastalıklarının ayırıcı tanısında kullanılan değerli bir in vivo tanı yöntemidir. Yöntemde tanı, foliküler açıklıklar, kıl gövdeleri ve perifoliküler epidermis olmak üzere dermoskopla görülebilen temel yapıların değerlendirilmesine dayalıdır. Bu yöntem klinikte, erken androgenetik alopesi tanısında, androgenetik alopesi ve telojen efluvium ayırımında, yamasal alopesilerin ayırıcı tanısında ve skarlı alopesilerin skarsız alopesilerden ayrımında fayda sağlar. Bu makale, trikoskopide gözlenen temel yapısal özelliklere ait anormalliklerle ilgili şuanki bilgilerimizi ve sık görülen saç hastalıklarının karakteristik görünümlerini özetlemektedir. Anahtar kelimeler: Trikoskopi, dermoskopi, saç, alopesi, saç hastalıkları Çıkar Çatışması: Yazarlar bu makale ile ilgili olarak herhangi bir çıkar çatışması bildirmemiştir. Özlem Dicle Trikoskopi Trichoscopy Özet AbstractTrichoscopy (hair and scalp dermoscopy) is a valuable in vivo tool for the differential diagnosis of clinically frequent hair diseases. It is based on evaluation of basic structures that may be visualized with a dermascope; follicular openings, hair shafts and perifollicular epidermis. This method is useful to diagnose early androgenetic alopecia, to distinguish androgenetic alopecia from telogen effluvium, to make differential diagnosis of patchy alopecias and differentiate scarring from nonscarring alopecias. This article summarizes the current knowledge in abnormal appearances of basic structural components on trichoscopy and characteristic trichoscopic features of the most common hair diseases.

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Histological features of peripilar signs associated with androgenetic alopecia

Abstract: PPS could be the clinical signs reflecting the presence of perifollicular infiltrates.

Cited by 114 publications

References 17 publications

Trichoscopy (hair and scalp videodermoscopy) in the healthy female. Method standardization and norms for measurable parameters

Trichoscopy (hair and scalp videodermoscopy) in the healthy female. Method standardization and norms for measurable parameters

Prostaglandin metabolism in human hair follicle

Trichoscopy

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