Background
Platelet‐rich plasma (PRP) treatment for androgenetic alopecia (AGA) has been increasingly used, yet there remains a dearth of data on the effectiveness of this approach.
Aim
To compare the efficacy and safety of physically activated PRP injections vs placebo in the treatment of male AGA.
Methods
Twenty‐five healthy male patients with AGA were enrolled in a randomized, placebo‐controlled, crossover study with the treatments of PRP and placebo. Treatment efficacy was measured by calculating the hair density as the average of two independent blind measurements.
Results
In the group that received placebo first (Group 2), we detected a significant increase in hair density at the secondary endpoints after PRP treatment (P = .014). There was a greater proportion of patients with low‐grade alopecia in this group (53.3%) compared to Group 1 (30%).
Conclusion
This study provides data supporting the positive effects of PRP treatment on AGA in males, but further studies are needed to identify those factors that might affect PRP treatment performance, such as the stage of the disease.
1. The study was conducted to investigate the effect of dietary protein on the walking ability and bone parameters of broilers reared under summer temperatures which ranged from 26 degrees to 32 degrees C (+/- 2 degrees C). 2. Three different dietary protein combinations were used. The diets (per kg) were: low protein with 205 g crude protein and 12.94 MJ ME, 184 g crude protein and 12.75 MJ ME; medium protein with 219 g crude protein and 12.99 MJ ME, 201 g crude protein and 12.87 MJ ME; and high protein with 238 g crude protein and 12.99 MJ ME, 216 g crude protein and 12.96 MJ ME from 0 to 4 and 4 to 7 weeks of age, respectively. Body weights of birds were recorded and birds' walking ability (gait scoring) were scored for each bird, according to 3 categories (completely normal to immobile, at 4 and 7 weeks). Tibia parameters and tibia plateau angles were also determined at 7 weeks. 3. Birds fed on the low protein were lighter than those fed on the medium or high protein diets. At 7 weeks, birds with poor walking ability weighted 149 g less than birds with no walking difficulty. 4. Bone parameters were not affected by dietary protein, sex or gait score. There was a significantly positive correlation between bone strength and radiographic density. Bone strength was also significantly correlated with bone weight and length.
We found that there was a discrepancy during the PUVA, Re-PUVA and NB-UVB treatments. We believe that VEGF plasma levels could not be a useful monitor of psoriasis activity and/or treatment response.
Rituximab is a beneficial and relatively safe adjuvant treatment for PV that facilitates prolonged clinical remission and has a significant steroid-sparing effect.
G-CSF has beneficial effects on the healing duration and pain severity of OU and GU of patients with BD. However, given the high cost, impractical preparation and inability to cure the disease, G-CSF treatment should be chosen only in selected patients.
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