Histological findings on fetal striatal grafts in a Huntington's disease patient early after transplantation

Cellular Therapy and Induced Neuronal Replacement for Huntington's Disease

“…Given these divergent reports, predicated on trials involving different cell preparation and implantation protocols and invariably small sample sizes, there is a clear need for a larger scale, technically standardized, and well-controlled evaluation. To this end, there are currently 3 ongoing clinical trials, part of the Euro-HD Multicenter, Randomized Controlled Phase II study, which is intended to re-assess graft efficacy using improved tissue preparation and surgical protocols [19,20].…”

Stem cells in neurology - current perspectives

“…Another issue to consider is how long a transplant may be clinically effective, as it has also been observed that transplanted neurons undergo apoptosis even when they do not contain huntingtin aggregates that are different from the surrounding host tissue 29 . In a histological study performed by Capetian et al 30 , a probable maturation pattern was observed in the graft. The nucleus was composed of immature and highly proliferative cells that produced a supply of migratory cells; these cells in turn, after crossing the grafthost barrier, migrated to other regions; after they traveled some distance, differentiation took place.…”

Progress and prospects: stem cells and neurological diseases

“…Neuronal and glial degeneration following cerebrovascular damage (stroke) can occur in any area of the brain. Integration of grafted tissue without clinical improvement 1 C a p e t i a net al 14 Stem cells and neurological diseases S Gögel et al additional immunosuppressive therapy as antibodies against foetal donor antigens were detected in patient's blood samples. 10 Similar results have been obtained in a separate study initiated by Kopyov and colleagues in Los Angeles.…”