Histological grading of therapy induced regression in squamous cell carcinomas of the oral cavity

Braun, Otto; Neumeister, B; Neuhold, N.; Siebenhandl, A.; Wimmer, M; Holzner, Johann; Popp, Wolfgang; Strassl, H; Dobrowsky, W.; Gritzmann, N.

doi:10.1016/s0344-0338(89)80015-9

Cited by 15 publications

(8 citation statements)

References 11 publications

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“…In the investigation of induction chemotherapy, pathologic evaluation and results are more exact and revealing than clinical responses [35,40]. Pathologically qualitative and quantitative responses can be observed.…”

Section: Discussionmentioning

confidence: 99%

“…Pathologically qualitative and quantitative responses can be observed. Among the qualitative ones, inflammatory reactions (chronic lymphocytic and giant cell granulomatosus type), scar formation and/or myofibroblastic reaction, the histology type, necrosis and grade of tumors, and involved margin are usually evaluated, as some studies prove [40][41][42][43]. Both clinical and pathological results together may be informative about the efficiency of preoperative chemotherapy [44,45].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, initial tumor size was more unfavorable in this study (70%) than in Sutton's (45%) or Woolgar's (59%) paper. The post-chemotherapy histological picture may explain the difference, where, as it was published earlier, in many cases, a fibrous scar may separate the rest tumor from the healthy tissues [27,35,40,41,43].…”

Section: Discussionmentioning

confidence: 99%

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Neoadjuvant Chemotherapy: Does It Have Benefits for the Surgeon in the Treatment of Advanced Squamous Cell Cancer of the Oral Cavity?

Olasz

Szalma

Orsi

et al. 2009

Pathol. Oncol. Res.

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The purpose of this clinicopathological study was to evaluate the effects and efficiency of combined neoadjuvant chemotherapy related to surgical margin. 100 consecutively treated squamous cell cancer patients receiving a combined neoadjuvant therapy were selected (Bleomycin-Vincristin-Methotrexate (BVM) or BVM + Mitolactol or BVM + Cisplatin). After three courses of chemotherapy, the patients were operated on. The largest diameter of the primary tumors was compared before and after chemotherapy. In the surgical specimen, the involvement of surgical margin was assessed. The largest diameter before chemotherapy was: T2 30%; T3 55%; T4A 15%. After chemotherapy, the rest tumor was assessed in the surgical specimen as: no rest 11%; <2 cm 57%; 2-4 cm 28%; 4-6 cm 4%. The no rest and <2 cm (optimal operability) tumor was observed in T2: 94%; in T3: 73%; in the T4A: 0%. Severe side effects (Grade III-IV) were not observed. There was a significant decrease in size (P < 0.0001). Of the 100 surgical specimens, 83% had clear-, 9% close- and 8% involved margins. From T4A, there was a 40% (6 patients) involved margin. Based on the significantly better size and operability of primary T2-3, the mild side effects and the high (83%) percentage of clear surgical margins, that is better than other (without preoperative chemotherapy) results, sought the use of chemotherapy is recommended before surgery. Due to the 40% involved margin, we don't suggest surgery in T4A.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Neoadjuvant Chemotherapy: Does It Have Benefits for the Surgeon in the Treatment of Advanced Squamous Cell Cancer of the Oral Cavity?

Olasz

Szalma

Orsi

et al. 2009

Pathol. Oncol. Res.

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“…It facilitates complete resection, and therefore improves survival. The effectiveness of the treatment can be evaluated by a histological assessment of the regression grade [2]. In the presented study, histopathologic complete remission (ypT0) was observed in 19 patients (14%).…”

Section: Abbildungmentioning

confidence: 91%

Neoadjuvant Radiochemotherapy and Radical Resection for Advanced Squamous Cell Carcinoma of the Oral Cavity

et al. 2008

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“…Classification scores of tumour regression under radiotherapy and/or chemotherapy have been proposed in various studies 5,7,8 . In this study, we apply a four-grade score previously described by BRAUN et al 2,3 . Some authors have suggested that response to preoperative RCT was a valuable prognostic factor for local control and overall survival 11,13 .…”

mentioning

confidence: 99%

Preoperative radiochemotherapy and radical resection for stages II to IV oral and oropharyngeal cancer: grade of regression as crucial prognostic factor

Klug

Wutzl

Kermer

et al. 2005

International Journal of Oral and Maxillofacial Surgery

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Histological grading of therapy induced regression in squamous cell carcinomas of the oral cavity

Cited by 15 publications

References 11 publications

Neoadjuvant Chemotherapy: Does It Have Benefits for the Surgeon in the Treatment of Advanced Squamous Cell Cancer of the Oral Cavity?

Neoadjuvant Chemotherapy: Does It Have Benefits for the Surgeon in the Treatment of Advanced Squamous Cell Cancer of the Oral Cavity?

Neoadjuvant Radiochemotherapy and Radical Resection for Advanced Squamous Cell Carcinoma of the Oral Cavity

Preoperative radiochemotherapy and radical resection for stages II to IV oral and oropharyngeal cancer: grade of regression as crucial prognostic factor

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